• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

The relationship between aspirin consumption and hepatocellular carcinoma: a systematic review and meta-analysis
ConclusionAspirin may reduce the risk of HCC in both healthy population and patients with chronic liver disease. However, attention should be paid to adverse events such as gastrointestinal bleeding in patients with chronic liver disease.
Source: European Journal of Medical Research - July 8, 2023 Category: Research Source Type: research

Cancers, Vol. 15, Pages 3518: The Effect of Aspirin Use on Incident Hepatocellular Carcinoma & mdash;An Updated Systematic Review and Meta-Analysis
Cancers, Vol. 15, Pages 3518: The Effect of Aspirin Use on Incident Hepatocellular Carcinoma—An Updated Systematic Review and Meta-Analysis Cancers doi: 10.3390/cancers15133518 Authors: Jonathan Abdelmalak Natassia Tan Danny Con Guy Eslick Ammar Majeed William Kemp Stuart K. Roberts An increasing number of observational studies have described an association between aspirin use and a reduced risk of incident hepatocellular carcinoma. We performed this meta-analysis to provide a comprehensive and updated aggregate assessment of the effect of aspirin on HCC incidence. Two independent authors perf...
Source: Cancers - July 6, 2023 Category: Cancer & Oncology Authors: Jonathan Abdelmalak Natassia Tan Danny Con Guy Eslick Ammar Majeed William Kemp Stuart K. Roberts Tags: Systematic Review Source Type: research

Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF- κB p65-activated SLC7A11 transcription
In this study we investigated whether aspirin affected ferroptosis in liver cancer cells. RNA-seq analysis revealed that aspirin up-regulated 4 ferroptosis-related drivers and down-regulated 5 ferroptosis-related suppressors in aspirin-treated HepG2 cells. Treatment with aspirin (4 mM) induced remarkable ferroptosis in HepG2 and Huh7 cells, which was enhanced by the ferroptosis inducer erastin (10 μM). We demonstrated that NF-κB p65 restricted ferroptosis in HepG2 and Huh7 cells through directly binding to the core region of SLC7A11 promoter and activating the transcription of ferroptosis inhibitor SLC7A11, whereas aspir...
Source: Acta Pharmacologica Sinica - February 24, 2023 Category: Drugs & Pharmacology Authors: Yu-Fei Wang Jin-Yan Feng Li-Na Zhao Man Zhao Xian-Fu Wei Yu Geng Hong-Feng Yuan Chun-Yu Hou Hui-Hui Zhang Guo-Wen Wang Guang Yang Xiao-Dong Zhang Source Type: research

Does aspirin reduce the incidence, recurrence, and mortality of hepatocellular carcinoma? A GRADE-assessed systematic review and dose –response meta-analysis
ConclusionsThis meta-analysis found that aspirin use was independently associated with a reduced risk of HCC incidence, recurrence, and death. Furthermore, aspirin use influenced HCC occurrence in a dose-dependent and duration-dependent manner. However, an increased risk of bleeding with aspirin use was noted.
Source: European Journal of Clinical Pharmacology - November 5, 2022 Category: Drugs & Pharmacology Source Type: research

Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD
Cancer Cell. 2022 Aug 18:S1535-6108(22)00368-3. doi: 10.1016/j.ccell.2022.08.004. Online ahead of print.ABSTRACTPlatelets, the often-overlooked component of the immune system, have been shown to promote tumor growth. Non-alcoholic fatty liver disease (NAFLD) is a common disease in the Western world and rising risk for hepatocellular carcinoma (HCC). Unexpectedly, we observed that platelets can inhibit the growth of established HCC in NAFLD mice. Through pharmacological inhibition and genetic depletion of P2Y12 as well as in vivo transfusion of wild-type (WT) or CD40L-/- platelets, we demonstrate that the anti-tumor functio...
Source: Cancer Control - September 2, 2022 Category: Cancer & Oncology Authors: Chi Ma Qiong Fu Laurence P Diggs John C McVey Justin McCallen Simon Wabitsch Benjamin Ruf Zachary Brown Bernd Heinrich Qianfei Zhang Umberto Rosato Sophie Wang Linda Cui Jay A Berzofsky David E Kleiner Dale B Bosco Long-Jun Wu Chunwei Walter Lai Yaron Rot Source Type: research

Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF- κB/HAT1/PGAM1 signaling in liver cancer
This study aims to identify the effects of aspirin on modulating PGAM1 enzymatic activities in liver cancer. Here, we found that aspirin attenuated the PGAM1 succinylation to suppress the PGAM1 enzymatic activities and glycolysis in hepatoma cells. Mechanically, aspirin remarkably reduced the global succinylation levels of hepatoma cells, including the PGAM1 succinylation, which led to the block of conversion from 3-phosphoglycerate (3-PG) to 2-phosphoglycerate (2-PG) in cells. Interestingly, RNA-seq analysis identified that aspirin could significantly decrease the levels of histone acetyltransferase 1 (HAT1), a writer of ...
Source: Acta Pharmacologica Sinica - July 14, 2022 Category: Drugs & Pharmacology Authors: Yu-Fei Wang Li-Na Zhao Yu Geng Hong-Feng Yuan Chun-Yu Hou Hui-Hui Zhang Guang Yang Xiao-Dong Zhang Source Type: research

Aspirin use is associated with reduced risk for hepatocellular carcinoma
Ann Intern Med. 2022 Jul 5. doi: 10.7326/J22-0049. Online ahead of print.ABSTRACTWang Y, Wang M, Liu C, et al. Aspirin use and the risk of hepatocellular carcinoma: a meta-analysis. J Clin Gastroenterol. 2022. [Epub ahead of print.] 35316225.PMID:35785535 | DOI:10.7326/J22-0049
Source: Annals of Internal Medicine - July 5, 2022 Category: Internal Medicine Authors: Ronald L Koretz Source Type: research

Pages: 1  2