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Specialty: Drugs & Pharmacology
Cancer: Carcinoma

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Total 192 results found since Jan 2013.

Development of a simple, biocompatible and cost-effective Inulin- Diethylenetriamine based siRNA delivery system.
In conclusion, we developed a novel inulin-based siRNA delivery system able to efficiently release siRNA in JHH6 with negligible cytotoxicity thus opening the way for further testing in more complex in vivo models. PMID: 25845631 [PubMed - as supplied by publisher]
Source: European Journal of Pharmaceutical Sciences - April 3, 2015 Category: Drugs & Pharmacology Authors: Sardo C, Farra R, Licciardi M, Dapas B, Scialabba C, Giammona G, Grassi M, Grassi G, Cavallaro G Tags: Eur J Pharm Sci Source Type: research

Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
In conclusion, our results demonstrate that 12k has an inhibitory effect on growth of A549 cell by inducing cell cycle arrest and apoptosis. PMID: 25776505 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2015 Category: Drugs & Pharmacology Authors: Dai B, Wang W, Liu R, Wang H, Zhang Y Tags: Biomed Pharmacother Source Type: research

Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma
In conclusion, our results demonstrate that 12k has an inhibitory effect on growth of A549 cell by inducing cell cycle arrest and apoptosis.
Source: Biomedicine and Pharmacotherapy - February 8, 2015 Category: Drugs & Pharmacology Source Type: research

Cyclophilin D-mediated apoptosis attributes to sorafenib-induced cytotoxicity in clear cell -renal cell carcinoma.
In conclusion, our results suggested that CypD may represent a new therapeutic target for the treatment of ccRCC. Sorafenib induced apoptosis in ccRCC through CypD upregulation and this effect was related to the inhibition of p-ERK. PMID: 25614335 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - January 19, 2015 Category: Drugs & Pharmacology Authors: Hu W, Yuan Q, Liu XH, Zhu HC, Lv SQ, Wang XH Tags: Eur J Pharmacol Source Type: research

Momordica Charantia lectin exhibits antitumor activity towards hepatocellular carcinoma
Conclusion Our data show that the natural compound MCL manifests antitumor activities towards HCC and therefore suggest MCL as a promising chemotherapeutic agent.
Source: Investigational New Drugs - January 15, 2015 Category: Drugs & Pharmacology Source Type: research

Functional expression of choline transporter-like protein 1 (CTL1) in small cell lung carcinoma cells: A target molecule for lung cancer therapy
We examined the molecular and functional characterization of choline uptake in the small cell lung carcinoma cell line NCI-H69. Choline uptake was saturable and mediated by a single transport system. Interestingly, removal of Na+ from the uptake buffer strongly enhanced choline uptake. This increase in choline uptake under the Na+-free conditions was inhibited by dimethylamiloride (DMA), a Na+/H+ exchanger (NHE) inhibitor. Various organic cations and the choline analog hemicholinium-3 (HC-3) inhibited the choline uptake and cell viability. A correlation analysis of the potencies of organic cations for the inhibition of cho...
Source: Pharmacological Research - November 9, 2014 Category: Drugs & Pharmacology Source Type: research

TPX2 siRNA regulates growth and invasion of esophageal cancer cells
Conclusion siRNA could effectively inhibit the invasion and metastasis of EC9706 cells, promote the apoptosis of tumor cells and may become a new approach for treatment of esophageal carcinoma.
Source: Biomedicine and Pharmacotherapy - November 1, 2014 Category: Drugs & Pharmacology Source Type: research

Proapoptotic PEDF functional peptides inhibit prostate tumor growth-A mechanistic study.
This study investigates the ability and mechanism by which the functional PEDF peptides PEDF34 and PEDF44 suppress tumor growth. The results showed that death receptor pathway was activated by PEDF34 through up-regulation of FasL and activation of caspase-8 in both xenograft tumor tissues and PC-3 cells. FasL knockdown by siRNA or JNK-p inhibition attenuated apoptosis induced by PEDF34. NF-κB and PPARγ are crucial transcription factors for FasL expression. PEDF34 up-regulated PPARγ but did not affect NF-κB. PEDF34-induced up-regulation of FasL was abolished by siRNA-mediated PPARγ knockdown or using PPARγ inhibitor G...
Source: Biochemical Pharmacology - September 24, 2014 Category: Drugs & Pharmacology Authors: Gong Q, Qiu S, Li S, Ma Y, Chen M, Yao Y, Che D, Feng J, Cai W, Ma J, Yang X, Gao G, Yang Z Tags: Biochem Pharmacol Source Type: research

Novel siRNA Delivery System Using a Ternary Polymer Complex with Strong Silencing Effect and No Cytotoxicity.
Abstract We developed a novel small interfering RNA (siRNA) delivery system using a ternary complex with polyethyleneimine (PEI) and γ-polyglutamic acid (γ-PGA), which showed silencing effect and no cytotoxicity. The binary complexes of siRNA with PEI were approximately 73-102 nm in particle size and 45-52 mV in ζ-potential. The silencing effect of siRNA/PEI complexes increased with an increase of PEI, and siRNA/PEI complexes with a charge ratio greater than 16 showed significant luciferase knockdown in a mouse colon carcinoma cell line regularly expressing luciferase (Colon26/Luc cells). However, strong cy...
Source: Biological and Pharmaceutical Bulletin - August 9, 2014 Category: Drugs & Pharmacology Authors: Kodama Y, Shiokawa Y, Nakamura T, Kurosaki T, Aki K, Nakagawa H, Muro T, Kitahara T, Higuchi N, Sasaki H Tags: Biol Pharm Bull Source Type: research

MiR-506 suppresses proliferation of hepatoma cells through targeting YAP mRNA 3'UTR.
Conclusion:MiR-506 suppresses the proliferation of hepatoma cells by targeting YAP mRNA. PMID: 25087998 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - August 4, 2014 Category: Drugs & Pharmacology Authors: Wang Y, Cui M, Sun BD, Liu FB, Zhang XD, Ye LH Tags: Acta Pharmacol Sin Source Type: research

Improvement of Doxorubicin Efficacy Using Liposomal Anti-Polo-like Kinase 1 siRNA in Human Renal Cell Carcinomas
Molecular PharmaceuticsDOI: 10.1021/mp500245z
Source: Molecular Pharmaceutics - May 12, 2014 Category: Drugs & Pharmacology Authors: Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita and Hideyoshi Harashima Source Type: research

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
Abstract Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, could be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX), an oncoprotein from hepatitis B virus. When ASK was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. ASK induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from ASK-induced apoptosis, indicating that N...
Source: European Journal of Pharmacology - April 24, 2014 Category: Drugs & Pharmacology Authors: Moon J, Koh SS, Malilas W, Cho IR, Kaewpiboon C, Kaowinn S, Lee K, Jhun BH, Choi YW, Chung YH Tags: Eur J Pharmacol Source Type: research

Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response.
Abstract Proteasome inhibitors are a novel class of molecular-targeted anti-cancer drugs that suppress the degradation of malfolded proteins, trigger endoplasmic reticulum (ER) stress, and activate apoptosis signals. Glucose-regulated protein 78 (GRP78), a major ER chaperone, is one of the most important molecules for transduction of unfolded protein response (UPR) signals. In accordance with past findings that expression of GRP78 is elevated in cancer cells and helps to resist stress-induced apoptosis, GRP78 knockdown could be effective in anticancer therapy. We tested this hypothesis and found that transfection ...
Source: Biological and Pharmaceutical Bulletin - April 6, 2014 Category: Drugs & Pharmacology Authors: Matsumura K, Sakai C, Kawakami S, Yamashita F, Hashida M Tags: Biol Pharm Bull Source Type: research

Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
This study also shows that FL3 selectively kills poorly differentiated and highly aggressive carcinomal cells, but has little effect on normal stem-like cells. Thus FL3 offers great promise for cancer treatment since it is able to target the carcinogenic process without affecting normal cells. PMID: 24607276 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - March 4, 2014 Category: Drugs & Pharmacology Authors: Emhemmed F, Azouaou SA, Thuaud F, Schini-Kerth V, Désaubry L, Muller CD, Fuhrmann G Tags: Biochem Pharmacol Source Type: research

Cationic Lipid-Assisted Polymeric Nanoparticle Mediated GATA2 siRNA Delivery for Synthetic Lethal Therapy of KRAS Mutant Non-Small-Cell Lung Carcinoma
Molecular PharmaceuticsDOI: 10.1021/mp400714z
Source: Molecular Pharmaceutics - February 20, 2014 Category: Drugs & Pharmacology Authors: Song Shen, Chong-Qiong Mao, Xian-Zhu Yang, Xiao-Jiao Du, Yang Liu, Yan-Hua Zhu and Jun Wang Source Type: research