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A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Dermatological Complications After Solid Organ Transplantation
AbstractOrgan transplant recipients (OTRs) are a population at high risk for cutaneous adverse events. Their early recognition and appropriate treatment is an important component of the clinical management of OTRs and should be optimally dealt with by dermatologists working in the context of a transplant dermatology clinic. Skin examination should be a standard procedure before performing organ transplantation to assess conditions which may be difficult to manage after the transplant procedure has been performed or which may represent a contraindication to transplantation, e.g., malignant melanoma. It also offers an opport...
Source: Clinical Reviews in Allergy and Immunology - November 25, 2017 Category: Allergy & Immunology Source Type: research

An expert system for the diagnosis and management of oral ulcers
Publication date: April 2014 Source:Tanta Dental Journal, Volume 11, Issue 1 Author(s): Sh.A. Ali , H.I. Saudi The present research was conducted to introduce a Visual Basic expert system to help the postgraduate students in the diagnosis and treatment of the most common and rare oral ulcers. A total of sixty postgraduate students shared in the study. They received the system on a CD-ROM and asked to evaluate it using a printed questionnaire. The oral ulcerative conditions merged in the database included, aphthous ulcers, chancre, traumatic ulcers, histoplasmosis ulcers, acute herpetic ulcers, burns, herpangina, tubercul...
Source: Tanta Dental Journal - November 6, 2014 Category: Dentistry Source Type: research

Beneficial IFN-α treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency
Autosomal-recessive hyper-IgE syndrome (AR-HIES) is a rare primary immunodeficiency caused by loss-of-function mutations in the gene DOCK8 (dedicator of cytokinesis 8). HIES follows an autosomal-dominant or -recessive trait and is characterized by high serum IgE levels, eczema, recurrent respiratory and skin infections, and fungal infections. Allergic disease manifestations, viral infections, and an elevated risk of squamous cell carcinoma and lymphoma are characteristics of DOCK8 deficiency. Lymphopenia, insufficient T- and B-cell memory compartment, impaired lymphocyte proliferation to mitogens, and natural killer (NK) c...
Source: Journal of Allergy and Clinical Immunology - April 3, 2014 Category: Allergy & Immunology Authors: Cihan Papan, Beate Hagl, Valerie Heinz, Michael H. Albert, Oliver Ehrt, Julie Sawalle-Belohradsky, Jens Neumann, Martin Ries, Philip Bufler, Andreas Wollenberg, Ellen D. Renner Tags: Letters to the Editor Source Type: research