• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
Abstract Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, could be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX), an oncoprotein from hepatitis B virus. When ASK was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. ASK induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from ASK-induced apoptosis, indicating that N...
Source: European Journal of Pharmacology - April 24, 2014 Category: Drugs & Pharmacology Authors: Moon J, Koh SS, Malilas W, Cho IR, Kaewpiboon C, Kaowinn S, Lee K, Jhun BH, Choi YW, Chung YH Tags: Eur J Pharmacol Source Type: research

The role of von Willebrand factor as a biomarker of tumor development in hepatitis B virus-associated human hepatocellular carcinoma: a quantitative proteomic based study.
We report comparative plasma proteome profiles of HBV-associated HCC and nonmalignant chronic liver diseases, including chronic hepatitis B and cirrhosis. The quantification of these datasets showed altered abundance of 21 proteins in HBV-related HCC and provides a reference point for future applied and basic research. In addition, we have demonstrated that the candidate protein vWF is involved in the pathogenesis of HBV infection and replication, and also associated with clinicopathologic staging of HCC patients with HBV infection. Overall these findings provide information on the mechanism of HCC development, which may a...
Source: Journal of Proteomics - April 23, 2014 Category: Biochemistry Authors: Liu Y, Wang X, Li S, Hu H, Zhang D, Hu P, Yang Y, Ren H Tags: J Proteomics Source Type: research

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor
The objective of this study was to investigate the major determinant for the cell death induced by matrine in human hepatocellular carcinoma. We use human hepatocellular carcinoma cell line HepG2 and human hepatocellular carcinoma xenograft in nude mice as models to study the action of matrine in hepatocellular cancers. We found that caspase-dependent and -independent Program Cell Death (PCD) occurred in matrine-treated HepG2 cells, accompanied by the decreasing of mitochondrial transmembrane potential and the increasing ROS production. Further studies showed that AIF released from the mitochondria to the nucleus, and sile...
Source: Molecular Cancer - March 16, 2014 Category: Cancer & Oncology Authors: Huan ZhouMinying XuYa GaoZhigang DengHanwei CaoWenqing ZhangQiao WangBing ZhangGang SongYanyan ZhanTianhui Hu Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly malignant potential to suggest a poor prognosis. © 2013 UICC
Source: International Journal of Cancer - October 31, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research

High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly‐malignant potential
In conclusion, high uMtCK expression in HCC may be caused by hepatocarcinogenesis per se but not by loss of mitochondrial integrity, of which ASB9 could be a negative regulator, and associated with highly‐malignant potential to suggest a poor prognosis. © 2013 Wiley Periodicals, Inc.
Source: International Journal of Cancer - October 17, 2013 Category: Cancer & Oncology Authors: Baasanjav Uranbileg, Kenichiro Enooku, Yoko Soroida, Ryunosuke Ohkawa, Yotaro Kudo, Hayato Nakagawa, Ryosuke Tateishi, Haruhiko Yoshida, Seiko Shinzawa, Kyoji Moriya, Natsuko Ohtomo, Takako Nishikawa, Yukiko Inoue, Tomoaki Tomiya, Soichi Kojima, Tomokazu Tags: Early Detection and Diagnosis Source Type: research

5'-triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells.
In conclusion, our findings suggest that 3p-siRNA could act as a powerful bifunctional antiviral molecule with potential for developing a promising therapeutic against chronic HBV infection. PMID: 24099962 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - October 4, 2013 Category: Drugs & Pharmacology Authors: Chen X, Qian Y, Yan F, Tu J, Yang X, Xing Y, Chen Z Tags: Eur J Pharmacol Source Type: research

Cullin7: a new gene involved in liver carcinogenesis related to metabolic syndrome
Conclusions This study demonstrates specific genomic alterations in HCC/MS and points to CUL7 as a novel gene potentially involved in liver carcinogenesis associated with MS, the amplification of which might influence cell proliferation.
Source: Gut - April 30, 2013 Category: Gastroenterology Authors: Paradis, V., Albuquerque, M., Mebarki, M., Hernandez, L., Zalinski, S., Quentin, S., Belghiti, J., Soulier, J., Bedossa, P. Tags: Hepatic cancer Hepatology Source Type: research

SiRNA-targeted carboxypeptidase D inhibits hepatocellular carcinoma growth.
Abstract Carboxypeptidase D (CPD), a membrane-bound metallocarboxypeptidase that functions as a docking receptor for duck hepatitis B virus, is frequently overexpressed in human cancers. We have explored its expression pattern, clinical significance, and biological function of CPD in hepatocellular carcinoma (HCC). CPD expression was markedly elevated in HCCs relative to adjacent non-tumor liver tissues, as determined by quantitative real-time polymerase chain reaction and Western blot analysis. Immunohistochemistry showed that 164 of 400 (41%) HCCs had high expression of CPD. CPD overexpression was significantly ...
Source: Cell Biology International - April 16, 2013 Category: Cytology Authors: Jin T, Fu J, Feng XJ, Wang SM, Huang X, Zhu MH, Zhang SH Tags: Cell Biol Int Source Type: research

Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
Conclusions: In conclusion, we reported an additional mechanism for HCV evasion of host interferon responses in which viral NS4B protein targets STING/MITA to suppress the interferon signaling. Our results present important evidence for the control of interferon response by HCV, and shed more light on the molecular mechanisms underlying the persistence of HCV infection.
Source: Journal of Hepatology - March 29, 2013 Category: Gastroenterology Authors: Qiang Ding, Xuezhi Cao, Jie Lu, Bing Huang, Yong-Jun Liu, Nobuyuki Kato, Hong-Bing Shu, Jin Zhong Tags: Viral Hepatitis Source Type: research

Pages: 1  2  3  4  5