Filtered By:
Specialty: Biochemistry
Cancer: Epithelial Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 1414 results found since Jan 2013.
Salmonella inhibits tumor metastasis by downregulating epithelial cell adhesion molecules through the protein kinase-B/mammalian target of rapamycin signaling pathway
Int J Biol Macromol. 2023 Sep 14:126913. doi: 10.1016/j.ijbiomac.2023.126913. Online ahead of print.ABSTRACTEpithelial cell adhesion molecules (EpCAM) are highly expressed in many carcinomas and regulate the epithelial-mesenchymal transition, which is required for tumor metastasis. Furthermore, EpCAM overexpression induces tumor cells to develop a stem cell-like phenotype and promotes tumor progression. Targeting EpCAM may be a promising approach for inhibiting tumor metastasis and progression. Salmonella treatment suppresses tumor growth and reduces metastatic nodules in tumor-bearing mice. Based on these results, we hypo...
Source: International Journal of Biological Macromolecules - September 16, 2023 Category: Biochemistry Authors: Wei-Che Yen Qiao-Zhu Li Li-Hsien Wu Wei-Ya Lee Wen-Wei Chang Peng-Ju Chien Che-Hsin Lee Source Type: research
Nicotinic acetylcholine receptors in cancer: Limitations and prospects
Biochim Biophys Acta Mol Basis Dis. 2023 Sep 4:166875. doi: 10.1016/j.bbadis.2023.166875. Online ahead of print.ABSTRACTNicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as po...
Source: Biochimica et Biophysica Acta - September 6, 2023 Category: Biochemistry Authors: T Bele T Turk I Kri žaj Source Type: research
Steric hindrance and charge influence on the cytotoxic activity and protein binding properties of diruthenium complexes
Int J Biol Macromol. 2023 Sep 1:126666. doi: 10.1016/j.ijbiomac.2023.126666. Online ahead of print.ABSTRACTPaddlewheel diruthenium complexes are being used as metal-based drugs. It has been proposed that their charge and steric properties determine their selectivity towards proteins. Here, we explore these parameters using the first water-soluble diruthenium complex bearing two formamidinate ligands, [Ru2Cl(DPhF)2(O2CCH3)2], and two derivatives, [Ru2Cl(DPhF)(O2CCH3)3] and K2[Ru2(DPhF)(CO3)3] (DPhF- = N,N'-diphenylformamidinate), with one formamidinate. Their protein binding properties have been assessed employing hen egg w...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Aar ón Terán Giarita Ferraro Paola Imbimbo Ana E S ánchez-Peláez Daria Maria Monti Santiago Herrero Antonello Merlino Source Type: research
Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy
CONCLUSIONS: Overall, this study provided a new insight into the role of circRNAs in the mechanism of DDP-resistance in ovarian cancer. Hsa_circRNA_0000585 may be promising therapeutic targets for the enhancement of the sensitivity of ovarian cancer cells to cisplatin-mediated chemotherapy.PMID:37643536 | DOI:10.1016/j.bbrc.2023.08.048
Source: Biochemical and Biophysical Research communications - August 29, 2023 Category: Biochemistry Authors: Pei Du Xueyuan Xu Ying Wang Source Type: research
Cancer-associated fibroblasts drive early pancreatic cancer cell invasion via the SOX4/MMP11 signalling axis
In this study, we integrated and reanalysed single-cell data from the National Geoscience Data Centre (NGDC) database and confirmed that myofibroblast-like CAFs (myCAFs) mediated epithelial-mesenchymal transformation (EMT) and enhanced the invasion abilities of PDAC cells by secreting regulators of angiogenesis and metastasis. Furthermore, we constructed a differentiation trajectory of CAFs and revealed that reprogramming from iCAFs to myCAFs was associated with poor prognosis. Mechanistically, SOX4 was aberrantly activated in myCAFs, which promoted the secretion of MMP11 and eventually induced early cancer cell invasion. ...
Source: Biochimica et Biophysica Acta - August 26, 2023 Category: Biochemistry Authors: Fujing Ge Chenming Zeng Jiaer Wang Xiangning Liu Churun Zheng Hongyu Zhang Liu Yang Bo Yang Hong Zhu Qiaojun He Source Type: research
Structural characterization and in vitro anti-colon cancer activity of a homogeneous polysaccharide from Agaricus bisporus
Int J Biol Macromol. 2023 Aug 18:126410. doi: 10.1016/j.ijbiomac.2023.126410. Online ahead of print.ABSTRACTColon cancer is the third most prevalent cancer and the second most deadly cancer in the world. Anti-colon cancer activity of Agaricus bisporus polysaccharides has not been studied. In this paper, Agaricus bisporus polysaccharides were sequentially extracted by room temperature water, hot water, high pressure hot water, dilute alkaline solution and concentrated alkaline solution. A homogeneous polysaccharide (WAAP-1) was obtained using DEAE Cellulose-52 column. Physicochemical properties, structural characterization ...
Source: International Journal of Biological Macromolecules - August 20, 2023 Category: Biochemistry Authors: Ning Zhang Yong Liu Fang-Yuan Tang Lin-Yuan Yang Jun-Hui Wang Source Type: research
TRIM38 suppresses migration, invasion, metastasis, and proliferation in non-small cell lung cancer (NSCLC) via regulating the AMPK/NF- κB/NLRP3 pathway
Mol Cell Biochem. 2023 Aug 11. doi: 10.1007/s11010-023-04823-y. Online ahead of print.ABSTRACTAccumulating data have revealed the pivotal function of tripartite motif protein 38 (TRIM38) in tumors. In view of this, this investigation aims to explore the function and potential mechanism of TRIM38 in non-small cell lung cancer (NSCLC). A xenotypic tumor model was established in vivo by subcutaneously injecting NSCLC cells (2 × 106 cells) in tail vein of each mouse. Relative expression of TRIM38 mRNA was detected via quantitative real-time polymerase chain reaction (qRT-PCR). For exploring the role of TRIM38 in vivo and in v...
Source: Molecular and Cellular Biochemistry - August 11, 2023 Category: Biochemistry Authors: Kaihua Zhang Guihu Lin Zhenkai Nie Shan Jin Xiaohan Bing Zhantao Li Mingru Li Source Type: research
CRISPR-Cas9 based knockout of S100A8 in mammary epithelial cells enhances cell proliferation and triggers oncogenic transformation via the PI3K-Akt pathway: Insights from a deep proteomic analysis
This study provides novel insights into the role of S100A8 in cell proliferation and differentiation and its potential relevance to cancer biology. SIGNIFICANCE: The study suggests that maintaining S100A8 expression is critical for preserving healthy cell physiology, and dysregulation of S100A8 in healthy cells can lead to altered cellular physiology and higher proliferation, similar to cancerous growth. Therefore, targeting the PI3K-Akt pathway or regulating Pten expression, a negative regulator of the PI3K-Akt pathway, may be potential strategies for cancer treatment by controlling S100A8 dysregulation. Additionally, S10...
Source: Journal of Proteomics - August 6, 2023 Category: Biochemistry Authors: Parul Singh Syed Azmal Ali Sudarshan Kumar Ashok Kumar Mohanty Source Type: research
