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Association of Frequent Aspirin Use With Ovarian Cancer Risk According to Genetic Susceptibility
CONCLUSIONS AND RELEVANCE: The findings of this study suggest that genetic susceptibility to ovarian cancer based on currently identified common genetic variants does not appear to modify the protective association between frequent aspirin use and ovarian cancer risk. Future work should continue to explore the role of aspirin use for ovarian cancer prevention among individuals who are at higher risk for ovarian cancer.PMID:36826816 | DOI:10.1001/jamanetworkopen.2023.0666
Source: Cancer Control - February 24, 2023 Category: Cancer & Oncology Authors: Lauren M Hurwitz Penelope M Webb Susan J Jordan Jennifer A Doherty Holly R Harris Marc T Goodman Yurii B Shvetsov Francesmary Modugno Kirsten B Moysich Joellen M Schildkraut Andrew Berchuck Hoda Anton-Culver Argyrios Ziogas Usha Menon Susan J Ramus Anna H Source Type: research

Predictors of residual disease after debulking surgery in advanced stage ovarian cancer
CONCLUSIONS: Addition of ovarian tumor tissue markers to our multivariable prediction models based on epidemiologic/clinical data slightly improved the model performance, suggesting debulking status may be in part driven by tumor characteristics. Larger studies are warranted to identify those at high risk of poor surgical outcomes informing personalized treatment.PMID:36761962 | PMC:PMC9902593 | DOI:10.3389/fonc.2023.1090092
Source: Cancer Control - February 10, 2023 Category: Cancer & Oncology Authors: Farnoosh Abbas-Aghababazadeh Naoko Sasamoto Mary K Townsend Tianyi Huang Kathryn L Terry Allison F Vitonis Kevin M Elias Elizabeth M Poole Jonathan L Hecht Shelley S Tworoger Brooke L Fridley Source Type: research

Splenectomy at the time of primary or interval cytoreductive surgery for epithelial ovarian carcinoma: A review of outcomes
CONCLUSIONS: While splenectomy adds morbidity, it continues to offer benefit in those patients who can achieve optimal cytoreduction. Areas for quality improvement in post-splenectomy care include receipt of vaccinations, patient discharge information, and timely pancreatic fistula management.PMID:36114028 | DOI:10.1016/j.ygyno.2022.08.023
Source: Gynecologic Oncology - September 16, 2022 Category: Cancer & Oncology Authors: Shannon K Rush Brittany F Lees Dandi S Huang Megan F Peterson Ahmed Al-Niaimi Source Type: research

Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts
Cancer Prev Res (Phila). 2022 May 24:canprevres.0080.2022-2-17 13:34:46.470. doi: 10.1158/1940-6207.CAPR-22-0080. Online ahead of print.ABSTRACTMUTYH carriers have an increased colorectal cancer (CRC) risk in case-control studies, with loss of heterozygosity (LOH) as the presumed mechanism. We evaluated cancer risk among carriers in a prospective, population-based cohort of older adults. Additionally, we assessed if cancers from carriers demonstrated mutational signatures (G:C>T:A transversions) associated with early LOH. We calculated incident risk of cancer and CRC among 13,131 sequenced study participants of the ASPi...
Source: Cancer Control - May 24, 2022 Category: Cancer & Oncology Authors: Jonathan M Downie Moeen Riaz Jing Xie Minyi Lee Andrew T Chan Peter Gibbs Suzanne G Orchard Suzanne E Mahady Robert P Sebra Anne M Murray Finlay Macrae Eric Schadt Robyn L Woods John J McNeil Paul Lacaze Manish Gala Source Type: research

Fight Aging! Newsletter, April 4th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Phospho-Aspirin (MDC-22) inhibits pancreatic cancer growth in patient-derived tumor xenografts and KPC mice by targeting EGFR: Enhanced efficacy in combination with irinotecan
Neoplasia. 2021 Dec 27;24(2):133-144. doi: 10.1016/j.neo.2021.12.004. Online ahead of print.ABSTRACTNovel therapeutic strategies are needed in the fight against pancreatic cancer. We have previously documented the chemopreventive effect of MDC-22 in preclinical models of pancreatic cancer. In the present work, we examined the therapeutic effects of MDC-22 in patient-derived tumor xenografts (PDTXs) and in LSL-KrasG12D/+, LSL-Trp53R172H/+, Pdx1-Cre (KPC) genetically engineered mice, two complementary and clinically relevant animal models of pancreatic cancer. In addition, we evaluated whether MDC-22 could synergize with cur...
Source: Neoplasia - December 30, 2021 Category: Cancer & Oncology Authors: Cecilia Rodriguez Lanzi Ran Wei Dingyuan Luo Gerardo G Mackenzie Source Type: research

NSAIDs Sensitize Melanoma Cells to MEK Inhibition and Inhibit Metastasis and Relapse by Inducing Degradation of AXL
Pigment Cell Melanoma Res. 2021 Nov 8. doi: 10.1111/pcmr.13021. Online ahead of print.ABSTRACTMelanoma is highly heterogeneous with diverse genomic alterations and partial therapeutic responses. Emergence of drug-resistant tumor cell clones accompanied with high AXL expression level is one of the major challenges for anti-tumor clinical care. Recent studies have demonstrated that high AXL expression in melanoma cells mediated drug-resistance, epithelial-mesenchymal transition (EMT) and elevated survival of cancer stem cells (CSCs). Given that we have identified several non-steroidal anti-inflammatory drugs (NSAIDs) includi...
Source: Pigment Cell and Melanoma Research - November 8, 2021 Category: Cytology Authors: Yingshi Chen Yiwen Zhang Siqi Chen Weiwei Liu Yingtong Lin Hui Zhang Fei Yu Source Type: research

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