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Total 2931 results found since Jan 2013.
Serum basic fibroblast growth factor and interleukin-1 β predict the effect of first-line chemotherapy in patients with advanced gastric cancer
CONCLUSION: The FLOT regimen was effective in reducing the serum CEA, CA199, and TPS levels as well as in improving the 1-year survival rate of patients with good tolerability, making it worthy of clinical promotion and application.PMID:37731570 | PMC:PMC10507556 | DOI:10.12998/wjcc.v11.i26.6083
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Li Zheng Li-Hong Gan Ling Yao Bin Li Ya-Qin Huang Fu-Bao Zhang Meng-Qi Kuang Nian Fang Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
A metabolomic investigation of serum perfluorooctane sulfonate and perfluorooctanoate
CONCLUSIONS: In this large metabolomic study, we observed robust positive associations with PFOS for several molecules. Further investigation of these metabolites may offer insight into PFOS-related biologic effects.PMID:37716341 | DOI:10.1016/j.envint.2023.108198
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Jongeun Rhee Erikka Loftfield Demetrius Albanes Tracy M Layne Rachael Stolzenberg-Solomon Linda M Liao Mary C Playdon Sonja I Berndt Joshua N Sampson Neal D Freedman Steven C Moore Mark P Purdue Source Type: research
An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review
This article provides an update on using carbohydrate-based GNPs in liver cancer treatment, imaging, and drug administration. Selective surface modification of several carbohydrate types and further biological uses of GNPs are focused on.PMID:37714232 | DOI:10.1016/j.ijbiomac.2023.126889
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Abdullah R Alzahrani Ibrahim Abdel Aziz Ibrahim Naiyer Shahzad Imran Shahid Ibrahim M Alanazi Alaa Hisham Falemban Mohd Fahami Nur Azlina Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A biospectroscopic approach toward colorectal cancer diagnosis from bodily fluid samples via ATR-MIR spectroscopy combined with multivariate data analysis
In this study, a biospectroscopic approach was reported for the detection of spectral changes and biomarkers for the diagnosis of colorectal cancer (CC) cases from different bodily fluids (blood plasma, blood serum, saliva and colonoscopy disinfection/wash fluids) by using attenuated total reflection-mid infrared (ATR-MIR) spectroscopy. To recognize the molecular level changes in the spectral characteristics of CC and their healthy/control (CH) groups, different multivariate data analyses (HCA, LDA, PCA and SIMCA) were successfully performed over the data of ATR-MIR spectroscopy. Two hundred specimens were characterized in...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Fuzuli Tugrul Gonul Akin Geyik Berrin Yalinba ş Kaya Betul Peker Cengiz Sukriye Nihan Karuk Elmas Ibrahim Yilmaz Fatma Nur Arslan Source Type: research
The Influence of Ketogenic Diet on Gut Microbiota: Potential Benefits, Risks and Indications
Nutrients. 2023 Aug 22;15(17):3680. doi: 10.3390/nu15173680.ABSTRACTThe ketogenic diet (KD) restricts carbohydrate consumption, leading to an increase in ketone bodies, such as acetoacetate, β-hydroxybutyrate, and acetone, which are utilized as energy substrates. This dietary approach impacts several biochemical processes, resulting in improved clinical management of various disorders, particularly in childhood. However, the exact mechanisms underlying the efficacy of KD remain unclear. Interestingly, KD may also impact the gut microbiota, which plays a pivotal role in metabolism, nutrition, and the development of the imm...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Andrea Santangelo Antonio Corsello Giulia Carla Immacolata Spolidoro Chiara Maria Trovato Carlo Agostoni Alessandro Orsini Gregorio Paolo Milani Diego Giampietro Peroni Source Type: research
Carcinoembryonic antigen, carbohydrate antigen 199 and carbohydrate antigen 724 in gastric cancer and their relationship with clinical prognosis
CONCLUSION: The expression levels of serum tumor markers CEA, CA199 and CA724 in patients with GC are high and rise with the increase of TNM stage. The levels of CEA, CA199 and CA724 are related to age, TNM stage, lymph node metastasis and tumor diameter. The combined detection of CEA, CA199 and CA724 is helpful to improve the diagnostic accuracy of GC with high clinical guidance value.PMID:37663935 | PMC:PMC10473936 | DOI:10.4251/wjgo.v15.i8.1475
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Ran Wang Chun-Lei Zuo Rui Zhang Li-Mei Zhu Source Type: research
Improving prognosis and assessing adjuvant chemotherapy benefit in locally advanced rectal cancer with deep learning for MRI: a retrospective, multi-cohort study
CONCLUSION: The MuST model accurately and non-invasively predicted OS, DM, and LR. A specific and direct tool linking chemotherapy decisions and benefit quantification has also been provided.PMID:37660753 | DOI:10.1016/j.radonc.2023.109899
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 3, 2023 Category: Radiology Authors: Song Zhang Guoxiang Cai Peiyi Xie Caixia Sun Bao Li Weixing Dai Xiangyu Liu Qi Qiu Yang Du Zhenhui Li Zhenyu Liu Jie Tian Source Type: research
