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Total 468 results found since Jan 2013.

Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE
CONCLUSIONS: In patients with atherosclerotic cardiovascular disease, long-term achievement of lower LDL-C levels, down to <20 mg/dL (<0.5 mmol/L), was associated with a lower risk of cardiovascular outcomes with no significant safety concerns.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01764633.PMID:36779348 | DOI:10.1161/CIRCULATIONAHA.122.063399
Source: Circulation - February 13, 2023 Category: Cardiology Authors: Prakriti Gaba Michelle L O'Donoghue Jeong-Gun Park Stephen D Wiviott Dan Atar Julia F Kuder KyungAh Im Sabina A Murphy Gaetano M De Ferrari Zbigniew A Gaciong Kalman Toth Ioanna Gouni-Berthold Jose Lopez-Miranda Fran çois Schiele Fran çois Mach Jose H F Source Type: research

Endothelial Specific Deletion of Autotaxin Improves Stroke Outcomes
This study suggests that endothelial-specific ATX leads to increased LPA in the brain vasculature following ischemic-reperfusion and ultimately disrupts vascular permeability, resulting in adverse stroke outcomes.PMID:36766854 | DOI:10.3390/cells12030511
Source: Atherosclerosis - February 11, 2023 Category: Cardiology Authors: Susmita Bhattarai Utsab Subedi Shrivats Manikandan Sudha Sharma Papori Sharma Chloe Miller Md Shenuarin Bhuiyan Srivatsan Kidambi Vassilis Aidinis Hong Sun Sumitra Miriyala Manikandan Panchatcharam Source Type: research

Net benefit of diagnostic tests for multistate diseases: an indicator variables approach
J Biopharm Stat. 2023 Jan 29:1-28. doi: 10.1080/10543406.2023.2169928. Online ahead of print.ABSTRACTA limitation of the common measures of diagnostic test performance, such as sensitivity and specificity, is that they do not consider the relative importance of false negative and false positive test results, which are likely to have different clinical consequences. Therefore, the use of classification or prediction measures alone to compare diagnostic tests or biomarkers can be inconclusive for clinicians. Comparing tests on net benefit can be more conclusive because clinical consequences of misdiagnoses are considered. Th...
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Hani Samawi Ferdous Ahmed Gene Pennello Jingjing Yin Source Type: research

Cardiovascular outcomes in patients with cancer during a 5-year follow-up: Results from a French administrative database
CONCLUSIONS: In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events.PMID:36641244 | DOI:10.1016/j.acvd.2022.11.006
Source: Archives of Cardiovascular Diseases - January 14, 2023 Category: Cardiology Authors: J érémy Boyer Pierre Deharo Denis Angoulvant Fabrice Ivanes Jerome Ferrara Antoine Vaillier Jennifer Cautela Julien Herbert Christophe Saint Etienne Thomas Cuisset Franck Thuny Laurent Fauchier Source Type: research

Which DOAC Is Cost-Effective in Cancer-Associated Thrombosis? Which DOAC Is Cost-Effective in Cancer-Associated Thrombosis?
Until recently, clinicians had little evidence to guide their decisions about the most effective and safe treatment for the oldest patients with atrial fibrillation and recent stroke.Medscape Medical News
Source: Medscape Cardiology Headlines - January 4, 2023 Category: Cardiology Tags: Cardiology News Source Type: news

Intake of marine and plant-derived n-3 fatty acids and development of atherosclerotic cardiovascular disease in the Danish Diet, Cancer and Health cohort
CONCLUSIONS: A high intake of marine n-3 PUFA was associated with a lower risk of total ASCVD and acute major ischemic events, whereas no association could be demonstrated for the plant-derived ALA.PMID:36592188 | DOI:10.1007/s00394-022-03081-w
Source: Atherosclerosis - January 2, 2023 Category: Cardiology Authors: Christian S Bork S øren Lundbye-Christensen Stine K Ven ø Anne N Lasota Anne Tj ønneland Erik B Schmidt Kim Overvad Source Type: research

Breakfast Type and Cardiovascular Mortality: The Japan Collaborative Cohort Study
CONCLUSION: Compared to Japanese breakfast, mixed Japanese-Western breakfast may have a protective role in cardiovascular mortality whereas skipping breakfast may harm cardiovascular health.PMID:36543187 | DOI:10.5551/jat.63564
Source: Journal of Atherosclerosis and Thrombosis - December 21, 2022 Category: Cardiology Authors: Jingyun Tang Jia-Yi Dong Ehab S Eshak Renzhe Cui Kokoro Shirai Keyang Liu Akiko Tamakoshi Hiroyasu Iso JACC study group Source Type: research

Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
Front Nutr. 2022 Nov 1;9:1007816. doi: 10.3389/fnut.2022.1007816. eCollection 2022.ABSTRACTMany local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation. The GSH tripeptide (γ- L-glutamyl-L-cysteinyl-glycine), the most abundant w...
Source: Atherosclerosis - November 17, 2022 Category: Cardiology Authors: Carlos A Labarrere Ghassan S Kassab Source Type: research

Proton Pump Inhibitor and Clopidogrel Use After Percutaneous Coronary Intervention and Risk of Major Cardiovascular Events
ConclusionsIn patients who receive clopidogrel after PCI, concomitant use of PPI seems to increase the risk of major cardiovascular events.
Source: Cardiovascular Drugs and Therapy - November 11, 2022 Category: Cardiology Source Type: research

Exercise for the Prevention of Anthracycline-induced Functional Disability and Cardiac Dysfunction: The BReast Cancer Randomized EXercise InTervention (BREXIT) Study
Conclusions: In women with early-stage BC undergoing AC, 12-months of ExT did not attenuate functional disability but provided large and clinically meaningful benefits on VO2peak and cardiac reserve. Clinical Trial Registration: URL: https://www.anzctr.org.au/ Unique Identifier: ACTRN12617001408370.PMID:36342348 | DOI:10.1161/CIRCULATIONAHA.122.062814
Source: Circulation - November 7, 2022 Category: Cardiology Authors: Stephen J Foulkes Erin J Howden Mark J Haykowsky Yoland Antill Agus Salim Sophie S Nightingale Sherene Loi Piet Claus Kristel Janssens Amy M Mitchell Leah Wright Ben T Costello Anniina Lindqvist Lauren Burnham Imogen Wallace Robin M Daly Steve F Fraser An Source Type: research