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Total 468 results found since Jan 2013.

Po-716-07 is cha2ds2vasc score useful for predicting the risk of stroke in patients with atrial fibrillation and cancer? : a single-center observational analysis
Patients with active cancer were historically excluded from clinical trials validating the CHA2DS2VASc score for stroke prediction in atrial fibrillation (AF). Limited data have questioned the predictive value of the score in patients with cancer and AF, underscoring the need for more personalized scores for prediction of stroke in these patients.
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Udhayvir S. Grewal, Mohammad Bhuiyan, Nachiket Madhav APTE, Parinita A. Dherange, Paari Dominic Source Type: research

Protective Effects and Therapeutics of Ginsenosides for Improving Endothelial Dysfunction: From Therapeutic Potentials, Pharmaceutical Developments to Clinical Trials
Am J Chin Med. 2022 Apr 13:1-24. doi: 10.1142/S0192415X22500318. Online ahead of print.ABSTRACTThe endothelium covers the internal lumen of the entire circulatory system and plays an important modulatory role in vascular homeostasis. Endothelium dysfunction, characterized by a vasoconstrictive, pro-inflammatory, and pro-coagulant state, usually manifests as a significant pathological process of vascular diseases, including hypertension, atherosclerosis (AS), stroke, diabetes mellitus, coronary artery disease, and cancer. Therefore, there is an urgent necessity to seek promising therapeutic drugs or remedies to ameliorate e...
Source: Atherosclerosis - April 22, 2022 Category: Cardiology Authors: Fang Yang Ming-Yue Yang Jing-Qing Le Bang-Yue Luo Meng-Die Yin None Chao-Li Jia-Li Jiang Yi-Fan Fang Jing-Wei Shao Source Type: research

Prognostic impact of a history of cancer and atrial fibrillation in antithrombotic therapy for chronic heart failure
ConclusionsThe CHF patients with history of cancer and AF had higher risk for stroke, systemic thrombosis, and major bleeding, especially in the elderly and those with IHD, but considerable number of the patients did not receive anticoagulant therapy, indicating the need for better optimal anticoagulation strategy.
Source: ESC Heart Failure - April 18, 2022 Category: Cardiology Authors: Kotaro Nochioka, Satoshi Yasuda, Yasuhiko Sakata, Takashi Shiroto, Hideka Hayashi, Jun Takahashi, Hiroyuki Takahama, Satoshi Miyata, Hiroaki Shimokawa Tags: Original Article Source Type: research

Deep Lipidomics in Human Plasma - Cardiometabolic Disease Risk and Effect of Dietary Fat Modulation
Conclusions: We identified several lipids associated with cardiometabolic disease risk. A subset was beneficially altered by a dietary fat intervention, which supports substitution of dietary saturated FAs with unsaturated FAs as a potential tool for primary disease prevention.PMID:35422138 | DOI:10.1161/CIRCULATIONAHA.121.056805
Source: Circulation - April 15, 2022 Category: Cardiology Authors: Fabian Eichelmann Laury Sellem Clemens Wittenbecher Susanne J äger Olga Kuxhaus Marcela Prada Rafael Cuadrat Kim G Jackson Julie A Lovegrove Matthias B Schulze Source Type: research

Body Mass Index and Mortality from Nonrheumatic Aortic Valve Disease among Japanese Men and Women
CONCLUSIONS: Overweight and obesity may be independent risk factors for nonrheumatic aortic valve disease mortality in Asian populations.PMID:35418541 | DOI:10.5551/jat.63452
Source: Journal of Atherosclerosis and Thrombosis - April 14, 2022 Category: Cardiology Authors: Masayuki Teramoto Kazumasa Yamagishi Renzhe Cui Kokoro Shirai Akiko Tamakoshi Hiroyasu Iso Source Type: research

Vertebral artery stenosis predicts cerebrovascular diseases following radiotherapy for nasopharyngeal carcinoma
CONCLUSION: Our study found that NPC patients with vertebral artery stenosis, atrial fibrillation, or hypertension carry a higher risk for ischemic stroke or TIA. Regular assessment of vertebral artery after radiotherapy was suggested.PMID:35357575 | DOI:10.1007/s00520-022-07011-8
Source: Atherosclerosis - March 31, 2022 Category: Cardiology Authors: Chien-Fu Yeh Yu-Ching Chin Wei Hung Pin-I Huang Ming-Ying Lan Source Type: research

Atherosclerotic cardiovascular events associated with immune checkpoint inhibitors in cancer patients
Jpn J Clin Oncol. 2022 Mar 28:hyac041. doi: 10.1093/jjco/hyac041. Online ahead of print.ABSTRACTImmune checkpoint inhibitors have demonstrated significant clinical benefits in many cancers, and the use of these drugs is rapidly expanding. Unfortunately, these agents can induce a wide range of immune-related adverse events through the activation of immune responses in non-target organs, including the cardiovascular system. Among cardiovascular immune-related adverse events, myocarditis is the most established and biologically plausible cardiac complication of immune checkpoint inhibitors therapy with immune-related pathophy...
Source: Atherosclerosis - March 29, 2022 Category: Cardiology Authors: Kazuko Tajiri Ikuo Sekine Source Type: research

Immunomodulatory Therapeutic Effects of Curcumin on M1 / M2 Macrophage polarization in Inflammatory Diseases
CONCLUSION: Curcumin not only enhances anti- tumor immunity (via shifting M polarization towards to M1 phenotype and/or up-regulation of M1 markers expression), but ameliorates inflammatory diseases including auto immune diseases (experimental autoimmune myocarditis and Behcet's disease), nephropathy, chronic serum sickness, stroke and atherosclerosis.PMID:35331128 | DOI:10.2174/1874467215666220324114624
Source: Atherosclerosis - March 25, 2022 Category: Cardiology Authors: Elham Abdollahi Thomas P Johnston Zahra Ghaneifar Parviz Vahedi Pouya Goleij Sara Azhdari Abbas Shapouri Moghaddam Source Type: research

Comparing pharmacotherapy in MINOCA versus medically managed obstructive acute coronary syndrome
This study uniquely compares the management and outcomes of MINOCA patients with a medically managed obstructive ACS (M-ACS) population. We retrospectively analysed registry data for consecutive patients admitted to the Gold Coast University Hospital with ACS requiring coronary angiography and identified patients with MINOCA and M-ACS. Baseline characteristics, pharmacological therapy and in-hospital outcomes were compared. In hospital outcomes were composite NACE, heart failure, stroke and major bleeding. Multivariate regression analysis was also performed to identify independent predictors of MINOCA. Multivariate regress...
Source: Heart and Vessels - March 23, 2022 Category: Cardiology Source Type: research