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Drug: Lithium

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Total 107 results found since Jan 2013.

Resveratrol induces the growth inhibition of CDX-deficient gastric cancer cells using CDX2 and RUNX3 via the β-catenin/TCF4 signaling pathway
This study aimed to determine the expression levels of runt-related transcription factor 3 (RUNX3) and caudal-related homeobox 2 (CDX2) in patients with chronic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer (GC). To analyze the overexpression of CDX2 and the effects of resveratrol (Res) on MKN7 and TMK1 cells, immunohistochemical staining was performed to determine the protein expression levels in tissue samples. The biological activity of MKN7 and TMK1 cells was determined. Relative mRNA and protein expression levels were also determined. RUNX3 expression was positively correlated with CDX2 ex...
Source: Cell Research - June 24, 2023 Category: Cytology Authors: Hui Liu Xinxin Zhang Can Fang Shuguang Li Source Type: research

Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target
This study aimed to quantify the relative biological effectiveness (RBE) for epithermal neutron beam contaminated with fast neutrons in the accelerator-based boron neutron capture therapy (BNCT) system coupled to a solid-state lithium target. The experiments were performed in National Cancer Center Hospital (NCCH), Tokyo, Japan. Neutron irradiation with the system provided by Cancer Intelligence Care Systems (CICS), Inc. was performed. X-ray irradiation, which was assigned as the reference group, was also performed using a medical linear accelerator (LINAC) equipped in NCCH. The four cell lines (SAS, SCCVII, U87-MG and NB1...
Source: Cell Research - June 9, 2023 Category: Cytology Authors: Satoshi Nakamura Shoji Imamichi Kenzi Shimada Mihiro Takemori Yui Kanai Kotaro Iijima Takahito Chiba Hiroki Nakayama Tetsu Nakaichi Shohei Mikasa Yuka Urago Tairo Kashihara Kana Takahashi Teiji Nishio Hiroyuki Okamoto Jun Itami Masamichi Ishiai Minoru Suz Source Type: research

Selectivity of cation transport across lipid membranes by the antibiotic salinomycin
Biochim Biophys Acta Biomembr. 2023 Jun 3:184182. doi: 10.1016/j.bbamem.2023.184182. Online ahead of print.ABSTRACTThe ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical for its therapeutic activity, are rather scarce. In the present work, we studied the ability of salinomycin to exert cation/H+-exchange across artificial bilayer lipid membranes (BLM) by measuring electrical potential on planar BLM in the presence of a protonophore and fluorescence responses of the...
Source: Biochimica et Biophysica Acta - June 5, 2023 Category: Biochemistry Authors: Tatyana I Rokitskaya Alexander M Firsov Ljudmila S Khailova Elena A Kotova Yuri N Antonenko Source Type: research

D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting
Brain Sci. 2023 Apr 21;13(4):697. doi: 10.3390/brainsci13040697.ABSTRACTCancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the tastant, for example, a saccharin solution (i.e., the conditioned stimulus; CS), resulted in conditioned taste aversion (CTA) to the CS intake. The present study employed an animal model of LiCl-induced CTA to imitate chemotherapy-induced nausea and vomiting symptoms. Recently, the basolateral amygdala...
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: Zhi-Yue Gao Chung Ming Huang Cai-N Cheng Andrew Chih-Wei Huang Source Type: research

An evaluation of the effect of lithium on taxane-induced neuropathy
CONCLUSIONS: Lithium does not appear to significantly lessen the risk of neuropathy for patients receiving paclitaxel.IMPLICATIONS FOR CANCER SURVIVORS: Targeted approaches for preventing CIPN are desperately needed. Despite sound scientific rationale, the current study did not identify neuroprotective properties of lithium.PMID:37097406 | DOI:10.1007/s00520-023-07775-7
Source: Cancer Control - April 25, 2023 Category: Cancer & Oncology Authors: David C Kochan Paul J Novotny Elizabeth J Cathcart-Rake Jacob J Orme Amye J Tevaarwerk Kathryn J Ruddy Daniel S Childs Source Type: research

Construction of quaternary stereocenters at carbon 2' of nucleosides
Carbohydr Res. 2023 Apr 15;528:108814. doi: 10.1016/j.carres.2023.108814. Online ahead of print.ABSTRACTThe non-natural nucleosides with a quaternary stereogenic center at C2' are crucial to drug discovery. They have become a cornerstone for the treatment of cancer and various viral infections as exemplified by gemcitabine and sofosbuvir. Major research effort has been expended to gain synthetic access to these nucleoside analogues with a significant steric bulk at C2' in the furanoside ring. The 2'-ketonucleosides and 2'-deoxy-2'-methylenenucleosides emerged as key intermediates in these synthetic strategies. For example,...
Source: Carbohydrate Research - April 23, 2023 Category: Genetics & Stem Cells Authors: Yong Liang Ellie Smerznak Stanislaw F Wnuk Source Type: research

Advances in the Therapeutic Potential of Inhibitors Targeting Glycogen Synthase Kinase 3 in Inflammatory Diseases
In this study, we analyzed nearly 30 different small-molecule GSK3 inhibitors reported in the past 4 years and classified them into four categories (thiazole, pyridine, F-substituted benzene, and others) according to their structure to conduct further literature research. Moreover, we summarized the optimal compounds and described the process of transformation from the lead compound to the optimal compound. In addition, we aimed to summarize the role of GSK3 in the pathogenesis of inflammatory diseases, with insights into the recent progress in the discovery of GSK3 inhibitors.PMID:37055897 | DOI:10.2174/1389557523666230412083123
Source: Mini Reviews in Medicinal Chemistry - April 14, 2023 Category: Chemistry Authors: Yifan Zhu Hui Wang Yueyue Guo Jie Cao Huanqiu Li Source Type: research

Association Between Estimated Geocoded Residential Maternal Exposure to Lithium in Drinking Water and Risk for Autism Spectrum Disorder in Offspring in Denmark
CONCLUSIONS AND RELEVANCE: Estimated maternal prenatal exposure to lithium from naturally occurring drinking water sources in Denmark was associated with an increased ASD risk in the offspring. This study suggests that naturally occurring lithium in drinking water may be a novel environmental risk factor for ASD development that requires further scrutiny.PMID:37010840 | DOI:10.1001/jamapediatrics.2023.0346
Source: Cancer Control - April 3, 2023 Category: Cancer & Oncology Authors: Zeyan Liew Qi Meng Qi Yan J örg Schullehner Birgitte Hansen S øren Munch Kristiansen Denitza D Voutchkova J ørn Olsen Annette Kj ær Ersbøll Matthias Ketzel Ole Raaschou-Nielsen Beate R Ritz Source Type: research

Phloretin induces G2/M arrest and apoptosis by suppressing the β-catenin signaling pathway in colorectal carcinoma cells
In conclusion, our results strongly suggested that phloretin can be utilized as a nutraceutical anticancer agent for combating CRC.PMID:36884140 | DOI:10.1007/s10495-023-01826-4
Source: Cell Research - March 8, 2023 Category: Cytology Authors: Smita Kapoor Yogendra S Padwad Source Type: research