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Cancer: Cancer
Drug: Insulin
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Total 2752 results found since Jan 2013.
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research
Identification of quality markers for < em > Cyanotis arachnoidea < /em > and analysis of its physiological mechanism based on chemical pattern recognition, network pharmacology, and experimental validation
In this study, ultra-high-performance liquid chromatography (UHPLC) fingerprint combined with chemical pattern recognition were performed, and four differential components were screened out as quality markers, including 20-Hydroxyecdysone, 3-O-acetyl-20-hydroxyecdysone, Ajugasterone C, and 2-O-acetyl-20-hydroxyecdysone. Network pharmacology analysis revealed 107 therapeutic target genes of Cyanotis arachnoidea in DM treatment, and the key targets were Akt1, TNF, IL-6, MAPK3, and JUN. The hypoglycemic mode of action of Cyanotis arachnoidea may be mediated by tumor necrosis factor (TNF) signaling, cancer, insulin resistance,...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Jingnan Hu Yu Feng Baolin Li Fengxia Wang Qi Qian Wei Tian Liying Niu Xinguo Wang Source Type: research
Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The dual role of citrate in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188987. doi: 10.1016/j.bbcan.2023.188987. Online ahead of print.ABSTRACTCitrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid synthesis, gluconeogenesis, insulin secretion, bone tissues formation, spermatozoid mobility, and immune response. Dysregulation of citrate metabolism is implicated in several pathologies, including cancer. Here we discuss how cancer cells use citrate to sustain their proliferation, survival, and metastatic progression. Also...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Philippe Icard Luca Simula Grit Zahn Marco Alifano Maria E Mycielska Source Type: research
The artificial pancreas: two alternative approaches to achieve a fully closed-loop system with optimal glucose control
CONCLUSION: This narrative review presents two lesser-explored viable solutions for AP systems and discusses the potential for improvement toward a fully automated system: A) using the intraperitoneal approach for more rapid insulin absorption, and B) besides using glucagon to treat and prevent hypoglycemia, also administering micro-boluses of glucagon to increase the local SC blood flow, thereby accelerating SC insulin absorption and SC glucose sensor site dynamics.PMID:37715091 | DOI:10.1007/s40618-023-02193-2
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: M K Åm I A Teigen M Riaz A L Fougner S C Christiansen S M Carlsen Source Type: research
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation
CONCLUSIONS: Our findings demonstrate that CerS6 deletion improves glucose homeostasis in alcohol-fed mice and exhibits sex-based differences in the attenuation of EtOH-induced weight gain and hepatic steatosis. Additionally, we unveil that CerS6 plays a major role as a regulator of lipid droplet biogenesis in alcohol-induced intra-hepatic lipid droplet formation, identifying it as a putative target for early ALD management.PMID:37714377 | DOI:10.1016/j.molmet.2023.101804
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Sookyoung Jeon Eleonora Scorletti Joseph Dempsey Delfin Buyco Chelsea Lin Yedidya Saiman Susovon Bayen Julia Harkin Jasmin Martin Royce Hooks Besim Ogretmen Josepmaria Argemi Luma Melo Ramon Bataller Rotonya M Carr Source Type: research
TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression
EMBO J. 2023 Sep 15:e113928. doi: 10.15252/embj.2023113928. Online ahead of print.ABSTRACTTo fulfill their function, pancreatic beta cells require precise nutrient-sensing mechanisms that control insulin production. Transcription factor EB (TFEB) and its homolog TFE3 have emerged as crucial regulators of the adaptive response of cell metabolism to environmental cues. Here, we show that TFEB and TFE3 regulate beta-cell function and insulin gene expression in response to variations in nutrient availability. We found that nutrient deprivation in beta cells promoted TFEB/TFE3 activation, which resulted in suppression of insuli...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Adrien Pasquier Nunzia Pastore Luca D'Orsi Rita Colonna Alessandra Esposito Veronica Maffia Rossella De Cegli Margherita Mutarelli Susanna Ambrosio Gennaro Tufano Antonio Grimaldi Marcella Cesana Davide Cacchiarelli Nathalie Delalleau Gennaro Napolitano A Source Type: research
FOXO transcription factors as mediators of stress adaptation
Nat Rev Mol Cell Biol. 2023 Sep 14. doi: 10.1038/s41580-023-00649-0. Online ahead of print.ABSTRACTThe forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16, which gained notoriety for its capability to double lifespan in the absence of daf-2 (the gene encoding the worm insulin receptor homologue). Since then, research has provided many mechanistic details on FOXO regulation and FOXO activity. Furthermore, conditional knockout experiments have provided a wealth of data as to how FOXOs control development and homeostasi...
Source: Cancer Control - September 14, 2023 Category: Cancer & Oncology Authors: Maria J Rodriguez-Colman Tobias B Dansen Boudewijn M T Burgering Source Type: research
