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Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTP β/ζ Axis: Relevance in Therapeutic Development
Conclusion The expression of the components of the PTN-MK-RPTPβ/ζ axis in immune cells and in inflammatory diseases suggests important roles for this axis in inflammation. Pleiotrophin has been recently identified as a limiting factor of metainflammation, a chronic pathological state that contributes to neuroinflammation and neurodegeneration. Pleiotrophin also seems to potentiate acute neuroinflammation independently of the inflammatory stimulus while MK seems to play different -even opposite- roles in acute neuroinflammation depending on the stimulus. Which are the functions of MK and PTN in chronic neuroi...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

UCLA helps many to live long and prosper
In Westwood, more than 100 faculty experts from 25 departments have embarked on anall-encompassing push to cut the health and economic impacts of depression in half by the year 2050. The mammoth undertaking will rely on platforms developed by the new Institute for Precision Health, which will harness the power of big data and genomics to move toward individually tailored treatments and health-promotion strategies.On the same 419 acres of land, researchers across the spectrum, from the laboratory bench to the patient bedside, are ushering in a potentially game-changing approach to turning the body ’s immune defenses again...
Source: UCLA Newsroom: Health Sciences - November 9, 2017 Category: Universities & Medical Training Source Type: news

Endocrine Disruptors and Health Effects in Africa: A Call for Action
Conclusion: To address the many challenges posed by EDCs, we argue that Africans should take the lead in prioritization and evaluation of environmental hazards, including EDCs. We recommend the institution of education and training programs for chemical users, adoption of the precautionary principle, establishment of biomonitoring programs, and funding of community-based epidemiology and wildlife research programs led and funded by African institutes and private companies. https://doi.org/10.1289/EHP1774 Received: 16 February 2017 Revised: 22 May 2017 Accepted: 24 May 2017 Published: 22 August 2017 Address correspond...
Source: EHP Research - August 23, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Commentary Source Type: research

Being overweight, not just obese, still carries serious health risks
Conclusion This impressively large global study demonstrates that the prevalence of obesity is increasing worldwide among both children and adults. It supports what has long been thought, that increased body mass index (BMI) contributes to a range of illnesses and is ultimately responsible for a large number of deaths, particularly from cardiovascular disease. One potential limitation is the use of self-reported BMI or health outcome data in some of the studies, although the majority used a specific independent measurement so this is unlikely to have biased results too much. It is also always difficult from observational d...
Source: NHS News Feed - June 13, 2017 Category: Consumer Health News Tags: Obesity Source Type: news

The Economic Benefits Of Healthier Eating: Why Corporations Can Be Natural Allies To Promote Better Diets
Nutrition is at the heart of many of the most important issues in our lives. From nourished children to vibrant aging, from social justice to sustainability, how we eat plays a major role in our health, our culture, and our happiness. Yet, we rarely consider the tremendous economic impact of our food choices. Suboptimal nutrition is the leading cause of poor health in the United States and globally, principally related to chronic diseases such as heart disease, stroke, obesity, diabetes, and several cancers. In many nations, the costs of healthcare dwarf other programs in the national budget. In the United States, nearly ...
Source: Healthy Living - The Huffington Post - July 1, 2016 Category: Consumer Health News Source Type: news

Inactivity 'twice as deadly' as obesity
Conclusion This study’s strengths included its large size and long follow-up period. Researchers also took into account a large number of factors (called confounders) that might have influenced the risk of death, such as diet, smoking history and alcohol intake, although it is still possible that both measured and unmeasured confounders influenced mortality rates. The study had one important limitation. It only measured people’s BMI (calculated by combining their weight and height) and their physical activity once, at the start of the study. It is quite possible that people’s BMI changed over time, and that this wou...
Source: NHS News Feed - January 15, 2015 Category: Consumer Health News Source Type: news

Nitrate-rich leafy greens 'good for the heart'
ConclusionIt’s always a good idea to eat up your greens. This research suggests that one possible benefit is through the mechanism of nitrate “thinning” the blood and protecting against heart disease.  While the research is interesting, it’s a pity that no one thought to mention that this was a laboratory study on rats. It is important to remember that high levels of nitrates can be toxic, which is why there are safety limits for the level of nitrates in drinking water. High nitrate levels are especially harmful for infants.A healthy diet – including plenty of vegetables – and regular exercise are important fo...
Source: NHS News Feed - December 4, 2014 Category: Consumer Health News Tags: Food/diet Heart/lungs Diabetes Obesity Source Type: news

UK 'among worst' for cancer linked to obesity
Conclusion This international study has shown alarming increases in cases of cancer that can be attributed to high BMI. Overall, they estimated that 3.6% of cancers in adults (aged over 30 years) worldwide are caused by high BMI, with the proportion attributed to obesity slightly higher in women than in men. In the UK, 4.4% of all cases of cancer per year in men and 8.2% of all cases of cancer per year in women, were estimated to be attributable to obesity. The research focused on cancers that the WCRF has already established are linked to high BMI. When looking at these cancers, the UK was joint second highest in the worl...
Source: NHS News Feed - November 27, 2014 Category: Consumer Health News Tags: Cancer Obesity Source Type: news

Five-year 'death test' provides few answers
ConclusionThis large population-based study was able to show which people were at increased risk of dying from cardiovascular, cancer or other causes over a five-year period. However, the researchers could not predict which illness a person may be at higher risk of getting or provide an opportunity for targeted prevention or treatment strategies. Strengths of the study include the large sample size and the fact participants were taken from the general population. The results also remained statistically significant after adjusting for age, sex, current disease and many other recognised indicators of chronic disease.However,...
Source: NHS News Feed - February 26, 2014 Category: Consumer Health News Tags: Heart/lungs Cancer Diabetes Medical practice Source Type: news