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Association of immune checkpoint inhibitors therapy with arterial thromboembolic events in cancer patients: A retrospective cohort study
CONCLUSION: ICI-treated patients may exhibit a higher risk of ATEs, especially after 1 year of treatment.PMID:37584246 | DOI:10.1002/cam4.6455
Source: Atherosclerosis - August 16, 2023 Category: Cardiology Authors: Jie Zhu Yue Chen Yuanlong Zhang Wei Wang Yujue Wang Zhuo Lu Yulin Zhang Haike Lei Dairong Li Bo Long Haixia Liu Source Type: research

Genes That Extend Lifespan May Do So by Mitigating the Increased Risk of Death Posed by Having Hypertension
Am J Hypertens. 2023 Aug 10:hpad070. doi: 10.1093/ajh/hpad070. Online ahead of print.ABSTRACTGenetic factors influence lifespan. In humans, there appears to be a particularly strong genetic effect in those aged ≥ 90 years. An important contribution is nutrient sensing genes which confer cell resilience. Our research has been investigating the genetic factors by longitudinal studies of American men of Japanese descent living on the island of Oahu in Hawaii. This cohort began as the Honolulu Heart Program in the mid-1960s and most subjects are now deceased. We previously discovered various genes containing polymorphisms as...
Source: American Journal of Hypertension - August 10, 2023 Category: Cardiology Authors: Brian J Morris Timothy A Donlon Source Type: research

Red Meat Consumption and its Relationship With Cardiovascular Health: A Review of Pathophysiology and Literature
Cardiol Rev. 2023 Jun 26. doi: 10.1097/CRD.0000000000000575. Online ahead of print.ABSTRACTRed meat is the muscle meat of mammals like beef, lamb, and pork that is red due to the abundance of myoglobin pigment and becomes even darker when cooked. The global average per capita consumption of meat and the total amount of meat consumed is rising, and there has been a particularly marked increase in the global consumption of chicken and pork. The consumption of red meat has always been a contentious issue, with data suggesting benefits in terms of nutritional value and at the same time linking its consumption to major health d...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Bhupinder Singh Abdul Allam Khan Fnu Anamika Ripudaman Munjal Jaskaran Munjal Rohit Jain Source Type: research

Incident cardiovascular events and imaging phenotypes in UK Biobank participants with past cancer
Conclusions Cancer history is linked to increased risk of incident CVDs and adverse cardiac remodelling independent of shared vascular risk factors.
Source: Heart - June 14, 2023 Category: Cardiology Authors: Raisi-Estabragh, Z., Cooper, J., McCracken, C., Crosbie, E. J., Walter, F. M., Manisty, C. H., Robson, J., Mamas, M. A., Harvey, N. C., Neubauer, S., Petersen, S. E. Tags: Open access, Editor's choice, Press releases Cardiac risk factors and prevention Source Type: research

Genomics of aging: Reactive oxidation and inefficient mitochondria
This article, the fifth in the JAANP Genomics of Aging series, describes the role that mitochondrial dysfunction plays in the development of age-related diseases such as Alzheimer disease, Parkinson disease, cancer, heart disease, and stroke.PMID:37265351 | DOI:10.1097/JXX.0000000000000880
Source: Atherosclerosis - June 2, 2023 Category: Cardiology Authors: Kenneth Wysocki Beth Heuer Source Type: research

Nuts and seeds consumption and risk of cardiovascular disease, type 2 diabetes and their risk factors: a systematic review and meta-analysis
CONCLUSION: There is a probable relationship between consumption of nuts/seeds and lower risk of CVD, mostly driven by CHD, possibly in part through effects on blood lipids. More research on stroke and T2D may affect the conclusions. The evidence of specific nuts should be further investigated.PMID:36816545 | PMC:PMC9930735 | DOI:10.29219/fnr.v67.8961
Source: Atherosclerosis - February 23, 2023 Category: Cardiology Authors: Erik Kristoffer Arnesen Birna Thorisdottir Linnea B ärebring Fredrik S öderlund Bright I Nwaru Ulrike Spielau Jutta Dierkes Alfons Ramel Christel Lamberg-Allardt Agneta Åkesson Source Type: research

Breakfast Type and Cardiovascular Mortality: The Japan Collaborative Cohort Study
CONCLUSION: Compared to Japanese breakfast, mixed Japanese-Western breakfast may have a protective role in cardiovascular mortality whereas skipping breakfast may harm cardiovascular health.PMID:36543187 | DOI:10.5551/jat.63564
Source: Journal of Atherosclerosis and Thrombosis - December 21, 2022 Category: Cardiology Authors: Jingyun Tang Jia-Yi Dong Ehab S Eshak Renzhe Cui Kokoro Shirai Keyang Liu Akiko Tamakoshi Hiroyasu Iso JACC study group Source Type: research

Glutathione: A Samsonian life-sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation
Front Nutr. 2022 Nov 1;9:1007816. doi: 10.3389/fnut.2022.1007816. eCollection 2022.ABSTRACTMany local and systemic diseases especially diseases that are leading causes of death globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart disease and stroke, cancer and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing coronavirus disease 19 (COVID-19), involve both, (1) oxidative stress with excessive production of reactive oxygen species (ROS) that lower glutathione (GSH) levels, and (2) inflammation. The GSH tripeptide (γ- L-glutamyl-L-cysteinyl-glycine), the most abundant w...
Source: Atherosclerosis - November 17, 2022 Category: Cardiology Authors: Carlos A Labarrere Ghassan S Kassab Source Type: research

Proton Pump Inhibitor and Clopidogrel Use After Percutaneous Coronary Intervention and Risk of Major Cardiovascular Events
ConclusionsIn patients who receive clopidogrel after PCI, concomitant use of PPI seems to increase the risk of major cardiovascular events.
Source: Cardiovascular Drugs and Therapy - November 11, 2022 Category: Cardiology Source Type: research

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.PMID:36314129 | DOI:10.1161/CIRCULATIONAHA.122.060700
Source: Circulation - October 31, 2022 Category: Cardiology Authors: Liam Gaziano Luanluan Sun Matthew Arnold Steven Bell Kelly Cho Stephen K Kaptoge Rebecca J Song Stephen Burgess Daniel C Posner Katja Mosconi Cassianne Robinson-Cohen Amy Mason Thomas R Bolton Ran Tao Elias Allara Petra Schubert Lingyan Chen James R Stale Source Type: research

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