Filtered By:
Condition: Autoimmune Disease
Cancer: Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 3099 results found since Jan 2013.
Diverse functions of myeloid-derived suppressor cells in autoimmune diseases
Immunol Res. 2023 Sep 21. doi: 10.1007/s12026-023-09421-0. Online ahead of print.ABSTRACTSince myeloid-derived suppressor cells (MDSCs) were found suppressing immune responses in cancer and other pathological conditions, subsequent researchers have pinned their hopes on the suppressive function against immune damage in autoimmune diseases. However, recent studies have found key distinctions of MDSC immune effects in cancer and autoimmunity. These include not only suppression and immune tolerance, but MDSCs also possess pro-inflammatory effects and exacerbate immune disorders during autoimmunity, while promoting T cell prol...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Xin Xiong Yang Zhang Yu Wen Source Type: research
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Microfluidic Single-Cell Migration Chip Reveals Insights into the Impact of Extracellular Matrices on Cell Movement
Lab Chip, 2023, Accepted Manuscript DOI: 10.1039/D3LC00651D, PaperMengli Zhou, Yushu Ma, Edwin C. Rock, Chun-Cheng Chiang, Kathryn E. Luker, Gary Luker, Yu-Chih Chen Cell migration is a complex process that plays a crucial role in normal physiology and pathologies such as cancer, autoimmune diseases, and mental disorders. Conventional cell migration assays face limitations... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - September 18, 2023 Category: Chemistry Authors: Mengli Zhou Source Type: research
Acquired angioedema due to C1-inhibitor-deficiency (AAE-C1-INH) - a bi-center retrospective study on diagnosis, course and therapy
CONCLUSION: AAE-C1-INH is characterized by late onset swellings mainly involving the face and low C1-INH levels. Diagnostic delay for AAE-C1-INH is further decreasing despite being about 10-fold rarer than HAE. Patients severely affected without underlying condition or no indication for treatment could benefit from off-label therapy.PMID:37716525 | DOI:10.1016/j.jaip.2023.09.003
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Felix Johnson Janina Hahn Benedikt Hofauer Jens Greve Barbara Wollenberg Thomas K Hoffmann Robin Lochbaum Susanne Trainotti Source Type: research
Intracavitary cardiac metastasis of cervical squamous cell carcinoma with immune thrombocytopenia: a rare case report
We present the case of an adult patient diagnosed with cervical cancer and concurrent right ventricular cancer thrombus, accompanied by immune thrombocytopenia (ITP). The patient exhibited resistance to conventional ITP drugs, with suboptimal platelet response. However, upon achieving initial control of the tumor, the patient's platelet counts returned to normal. Notably, the addition of immune checkpoint inhibitors targeting PD-L1 resulted in effective tumor control, accompanied by sustained high platelet levels. Unfortunately, during subsequent anti-tumor therapy, the patient experienced a prolonged platelet rise time, r...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ning Liu Deguan Lv Raydonna Rachel Schneider Hongyan Yang Mingyan Zhang Yanan Liu Meili Sun Source Type: research
Applications of oxetanes in drug discovery and medicinal chemistry
Eur J Med Chem. 2023 Sep 11;261:115802. doi: 10.1016/j.ejmech.2023.115802. Online ahead of print.ABSTRACTThe compact and versatile oxetane motifs have gained significant attention in drug discovery and medicinal chemistry campaigns. This review presents an overview of the diverse applications of oxetanes in clinical and preclinical drug candidates targeting various human diseases, including cancer, viral infections, autoimmune disorders, neurodegenerative conditions, metabolic disorders, and others. Special attention is given to biologically active oxetane-containing compounds and their disease-related targets, such as kin...
Source: European Journal of Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Guang Huang Devon Hucek Tomasz Cierpicki Jolanta Grembecka Source Type: research
Significant CA 19-9 Elevation in IgG4-Related Autoimmune Pancreatitis - A Diagnostic Dilemma
We describe the case of a 65-year-old male with history of IgG4-RD, presenting with jaundice and abdominal pain. He was found to have a pancreatic mass with significantly elevated IgG4 162 (2-96 mg/dL and CA19-9 levels 2830 (0-35 U/ml). Patient underwent ERCP and biopsy, which ruled out pancreatic cancer and cholangiocarcinoma. He was diagnosed with IgG4-RD autoimmune pancreatitis (AIP) and sclerosing cholangitis. Treatment with steroids and rituximab resulted in significant improvement in the bilirubin and a dramatic decrease in CA19-9 levels.PMID:37714269 | DOI:10.1016/j.amjms.2023.09.016
Source: The American Journal of the Medical Sciences - September 15, 2023 Category: General Medicine Authors: Larabe Farrukh Muhammad Farhan Akhtar Hafiza Hareem Waqar Ruben Peredo-Wende Source Type: research
Applications of oxetanes in drug discovery and medicinal chemistry
Eur J Med Chem. 2023 Sep 11;261:115802. doi: 10.1016/j.ejmech.2023.115802. Online ahead of print.ABSTRACTThe compact and versatile oxetane motifs have gained significant attention in drug discovery and medicinal chemistry campaigns. This review presents an overview of the diverse applications of oxetanes in clinical and preclinical drug candidates targeting various human diseases, including cancer, viral infections, autoimmune disorders, neurodegenerative conditions, metabolic disorders, and others. Special attention is given to biologically active oxetane-containing compounds and their disease-related targets, such as kin...
Source: European Journal of Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Guang Huang Devon Hucek Tomasz Cierpicki Jolanta Grembecka Source Type: research
Integrated BATF transcriptional network regulates suppressive intratumoral regulatory T cells
Sci Immunol. 2023 Sep 15;8(87):eadf6717. doi: 10.1126/sciimmunol.adf6717. Epub 2023 Sep 15.ABSTRACTHuman regulatory T cells (Tregs) are crucial regulators of tissue repair, autoimmune diseases, and cancer. However, it is challenging to inhibit the suppressive function of Tregs for cancer therapy without affecting immune homeostasis. Identifying pathways that may distinguish tumor-restricted Tregs is important, yet the transcriptional programs that control intratumoral Treg gene expression, and that are distinct from Tregs in healthy tissues, remain largely unknown. We profiled single-cell transcriptomes of CD4+ T cells in ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Feng Shan Anthony R Cillo Carly Cardello Daniel Y Yuan Sheryl R Kunning Jian Cui Caleb Lampenfeld Asia M Williams Alexandra P McDonough Arjun Pennathur James D Luketich John M Kirkwood Robert L Ferris Tullia C Bruno Creg J Workman Panayiotis V Benos Dario Source Type: research
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
MedComm (2020). 2023 Sep 11;4(5):e349. doi: 10.1002/mco2.349. eCollection 2023 Oct.ABSTRACTMacrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved in the occurrence and progression of various diseases, such as coronavirus disease 2019 and atherosclerosis. The protective or pathogenic effect that macrophages exert in different conditions largely depends on their functional plasticity, which is regulated via signal transduction such as Janus kinase-signal transducer and activator of transcription, Wnt and Notch pathways, stimulated by environmental cue...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ming Li Mengjie Wang Yuanjia Wen Hongfei Zhang Guang-Nian Zhao Qinglei Gao Source Type: research
Design and synthesis of amino-substituted < em > N < /em > -arylpiperidinyl-based inhibitors of the (immuno)proteasome
Acta Pharm. 2023 Sep 14;73(3):441-456. doi: 10.2478/acph-2023-0032. Print 2023 Sep 1.ABSTRACTThe constitutive proteasome and the immunoproteasome represent validated targets for pharmacological intervention in the context of various diseases, such as cancer, inflammation, and autoimmune diseases. The development of novel chemical scaffolds of non-peptidic nature, capable of inhibiting different catalytically active subunits of both isoforms, is a viable approach against these diseases. Such compounds are also useful as leads for the development of biochemical probes that enable the studies of the roles of both isoforms in ...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Martina Gobec Ale š Obreza Marko Juki č Ana Baumgartner Nja Mihel čič Špela Potočnik Julija Virant Irena Mlinari č Ra ščan Stanislav Gobec Izidor Sosi č Source Type: research
Signaling pathways in macrophages: molecular mechanisms and therapeutic targets
MedComm (2020). 2023 Sep 11;4(5):e349. doi: 10.1002/mco2.349. eCollection 2023 Oct.ABSTRACTMacrophages play diverse roles in development, homeostasis, and immunity. Accordingly, the dysfunction of macrophages is involved in the occurrence and progression of various diseases, such as coronavirus disease 2019 and atherosclerosis. The protective or pathogenic effect that macrophages exert in different conditions largely depends on their functional plasticity, which is regulated via signal transduction such as Janus kinase-signal transducer and activator of transcription, Wnt and Notch pathways, stimulated by environmental cue...
Source: Atherosclerosis - September 14, 2023 Category: Cardiology Authors: Ming Li Mengjie Wang Yuanjia Wen Hongfei Zhang Guang-Nian Zhao Qinglei Gao Source Type: research
