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Condition: Asthma
Cancer: Cancer
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Total 1400 results found since Jan 2013.
Anaphylaxis and systemic mastocytosis controlled with KIT inhibitors in a patient with metastatic lung adenocarcinoma
A 58 ‐year‐old female with indolent systemic mastocytosis (ISM) and metastatic non‐ small cell lung cancer (NSCLC) presented with anaphylaxis to osimertinib with three attempts at rapid drug desensitization (RDD).
Source: Annals of Allergy, Asthma and Immunology - August 16, 2023 Category: Allergy & Immunology Authors: Camellia L. Hernandez, Donna ‐Marie Lynch, Abby Jane Golash, Kathleen Marquis, Kylie Marie Besz, Geoffrey Oxnard, Julia Rotow, Daniel J. DeAngelo, Mariana Castells Tags: Letters Source Type: research
Eosinophils induces glioblastoma cell suppression and apoptosis - Roles of GM-CSF and cysteinyl-leukotrienes
CONCLUSION: Eosinophils have the potential to be key cells on glioblastoma therapeutics, as allergy and eosinophilia are correlated with a better glioblastoma prognosis. Eosinophils are elicited and attach to glioblastoma cells, where, by its cytotoxic function, via Fas/FasL, hind glioblastoma cell metabolism, proliferation, migration, and induce cell death.PMID:37536182 | DOI:10.1016/j.intimp.2023.110729
Source: International Immunopharmacology - August 3, 2023 Category: Allergy & Immunology Authors: Bruno Marques Vieira Vit ória Santório de São José Paulo Soares Niemeyer Filho Vivaldo Moura-Neto Source Type: research
IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):299-311. doi: 10.18502/ijaai.v22i3.13058.ABSTRACTT cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the rol...
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Mehrnoosh Pashei Farahnaz Ghahremanfard Ehsan Manouchehri Doulabi Maral Hemmati Fatemeh Pak Parviz Kokhaei Source Type: research
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis
Iran J Allergy Asthma Immunol. 2023 Apr 30;22(2):190-199. doi: 10.18502/ijaai.v22i2.12680.ABSTRACTThe pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that of cancer pathogenesis, and several pathways appear to be involved in both disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several established oncogenes and tumor suppressors. The same signaling molecules and growth factors, such as vascular endothelial growth factor (VEGF), contributing to cancer development and progression play a part in fibroblast proliferation, myofibroblast differentiation, and the production of extrac...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Marjan Taherian Paria Bayati Mohammad-Ali Assarehzadegan Mansoureh Soleimani Hadi Poormoghim Nazanin Mojtabavi Source Type: research
Astragalus Polysaccharide Mediates Immunomodulatory Effects on Crosstalk between Human Peripheral Blood Mononuclear Cells and Ovarian Cancer Cell Line
This study evaluated the effect of APS on the peripheral blood mononuclear cell (PBMC) proliferation, cytokine secretion, and regulatory T cell (Treg) induction in an in vitro coculture model of human PBMCs and A2780 human ovarian cancer cells. PBMC proliferation and Treg frequency were measured by flow cytometry. Cytokine levels were assessed by enzyme-linked immunosorbent assay. APS significantly enhanced the PBMC proliferation, reduced Treg frequency, decreased anti-inflammatory cytokines including interleukin [IL]-10, transforming growth factor beta (TGF-β), and vascular endothelial growth factor-A (VEGF-A), and incre...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Elham Shokati Morteza Motallebnezhad Elaheh Safari Source Type: research
Evaluation of Molecular-level Changes of Programmed Cell Death Ligand-1 after Radiation Therapy in a BALB/c CT26 Colorectal Mouse Tumor Model
In this study, female BALB/c mice inoculated with CT26 tumor cells were irradiated with 3 different RT regimens using the same BED of 40 gray (Gy). These included ablative RT (1*15 Gy), hypo-fractionated RT (2*10 Gy), and conventional (Hyper-fractionated) RT (10*3 Gy). PD-L1 expression was analyzed with immunohistochemical staining on days 2 and 20 and when the size of tumors had reached 2 cm2 after RT. All treated groups expressed PD-L1, but the group receiving single ablative high-dose RT showed higher expression compared to the other groups. No significant differences in PD-L1 expression were observed at different times...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Fateme Khani Chamani Mahdi Shabani Afshin Moradi Maedeh Alinejad Seyed Amir Jalali Source Type: research
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis
Iran J Allergy Asthma Immunol. 2023 Apr 30;22(2):190-199. doi: 10.18502/ijaai.v22i2.12680.ABSTRACTThe pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that of cancer pathogenesis, and several pathways appear to be involved in both disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several established oncogenes and tumor suppressors. The same signaling molecules and growth factors, such as vascular endothelial growth factor (VEGF), contributing to cancer development and progression play a part in fibroblast proliferation, myofibroblast differentiation, and the production of extrac...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Marjan Taherian Paria Bayati Mohammad-Ali Assarehzadegan Mansoureh Soleimani Hadi Poormoghim Nazanin Mojtabavi Source Type: research
Astragalus Polysaccharide Mediates Immunomodulatory Effects on Crosstalk between Human Peripheral Blood Mononuclear Cells and Ovarian Cancer Cell Line
This study evaluated the effect of APS on the peripheral blood mononuclear cell (PBMC) proliferation, cytokine secretion, and regulatory T cell (Treg) induction in an in vitro coculture model of human PBMCs and A2780 human ovarian cancer cells. PBMC proliferation and Treg frequency were measured by flow cytometry. Cytokine levels were assessed by enzyme-linked immunosorbent assay. APS significantly enhanced the PBMC proliferation, reduced Treg frequency, decreased anti-inflammatory cytokines including interleukin [IL]-10, transforming growth factor beta (TGF-β), and vascular endothelial growth factor-A (VEGF-A), and incre...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Elham Shokati Morteza Motallebnezhad Elaheh Safari Source Type: research
Evaluation of Molecular-level Changes of Programmed Cell Death Ligand-1 after Radiation Therapy in a BALB/c CT26 Colorectal Mouse Tumor Model
In this study, female BALB/c mice inoculated with CT26 tumor cells were irradiated with 3 different RT regimens using the same BED of 40 gray (Gy). These included ablative RT (1*15 Gy), hypo-fractionated RT (2*10 Gy), and conventional (Hyper-fractionated) RT (10*3 Gy). PD-L1 expression was analyzed with immunohistochemical staining on days 2 and 20 and when the size of tumors had reached 2 cm2 after RT. All treated groups expressed PD-L1, but the group receiving single ablative high-dose RT showed higher expression compared to the other groups. No significant differences in PD-L1 expression were observed at different times...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Fateme Khani Chamani Mahdi Shabani Afshin Moradi Maedeh Alinejad Seyed Amir Jalali Source Type: research
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis
Iran J Allergy Asthma Immunol. 2023 Apr 30;22(2):190-199. doi: 10.18502/ijaai.v22i2.12680.ABSTRACTThe pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that of cancer pathogenesis, and several pathways appear to be involved in both disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several established oncogenes and tumor suppressors. The same signaling molecules and growth factors, such as vascular endothelial growth factor (VEGF), contributing to cancer development and progression play a part in fibroblast proliferation, myofibroblast differentiation, and the production of extrac...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Marjan Taherian Paria Bayati Mohammad-Ali Assarehzadegan Mansoureh Soleimani Hadi Poormoghim Nazanin Mojtabavi Source Type: research
Astragalus Polysaccharide Mediates Immunomodulatory Effects on Crosstalk between Human Peripheral Blood Mononuclear Cells and Ovarian Cancer Cell Line
This study evaluated the effect of APS on the peripheral blood mononuclear cell (PBMC) proliferation, cytokine secretion, and regulatory T cell (Treg) induction in an in vitro coculture model of human PBMCs and A2780 human ovarian cancer cells. PBMC proliferation and Treg frequency were measured by flow cytometry. Cytokine levels were assessed by enzyme-linked immunosorbent assay. APS significantly enhanced the PBMC proliferation, reduced Treg frequency, decreased anti-inflammatory cytokines including interleukin [IL]-10, transforming growth factor beta (TGF-β), and vascular endothelial growth factor-A (VEGF-A), and incre...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Elham Shokati Morteza Motallebnezhad Elaheh Safari Source Type: research
Evaluation of Molecular-level Changes of Programmed Cell Death Ligand-1 after Radiation Therapy in a BALB/c CT26 Colorectal Mouse Tumor Model
In this study, female BALB/c mice inoculated with CT26 tumor cells were irradiated with 3 different RT regimens using the same BED of 40 gray (Gy). These included ablative RT (1*15 Gy), hypo-fractionated RT (2*10 Gy), and conventional (Hyper-fractionated) RT (10*3 Gy). PD-L1 expression was analyzed with immunohistochemical staining on days 2 and 20 and when the size of tumors had reached 2 cm2 after RT. All treated groups expressed PD-L1, but the group receiving single ablative high-dose RT showed higher expression compared to the other groups. No significant differences in PD-L1 expression were observed at different times...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Fateme Khani Chamani Mahdi Shabani Afshin Moradi Maedeh Alinejad Seyed Amir Jalali Source Type: research
Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis
Iran J Allergy Asthma Immunol. 2023 Apr 30;22(2):190-199. doi: 10.18502/ijaai.v22i2.12680.ABSTRACTThe pathogenesis of idiopathic pulmonary fibrosis (IPF) is quite similar to that of cancer pathogenesis, and several pathways appear to be involved in both disorders. The mammalian target of the rapamycin (mTOR) pathway harbors several established oncogenes and tumor suppressors. The same signaling molecules and growth factors, such as vascular endothelial growth factor (VEGF), contributing to cancer development and progression play a part in fibroblast proliferation, myofibroblast differentiation, and the production of extrac...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Marjan Taherian Paria Bayati Mohammad-Ali Assarehzadegan Mansoureh Soleimani Hadi Poormoghim Nazanin Mojtabavi Source Type: research
Astragalus Polysaccharide Mediates Immunomodulatory Effects on Crosstalk between Human Peripheral Blood Mononuclear Cells and Ovarian Cancer Cell Line
This study evaluated the effect of APS on the peripheral blood mononuclear cell (PBMC) proliferation, cytokine secretion, and regulatory T cell (Treg) induction in an in vitro coculture model of human PBMCs and A2780 human ovarian cancer cells. PBMC proliferation and Treg frequency were measured by flow cytometry. Cytokine levels were assessed by enzyme-linked immunosorbent assay. APS significantly enhanced the PBMC proliferation, reduced Treg frequency, decreased anti-inflammatory cytokines including interleukin [IL]-10, transforming growth factor beta (TGF-β), and vascular endothelial growth factor-A (VEGF-A), and incre...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 27, 2023 Category: Allergy & Immunology Authors: Elham Shokati Morteza Motallebnezhad Elaheh Safari Source Type: research
