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Expression of TCF3 in Burkitt's Lymphoma and Its Proliferative Effect and Prognostic Significance
CONCLUSION: There are mutation and abnormal expression of TCF3 in patients with BL. Patients with TCF3 mutations have low remission rate and poor prognosis.PMID:36208246 | DOI:10.19746/j.cnki.issn.1009-2137.2022.05.020
Source: Cancer Control - October 8, 2022 Category: Cancer & Oncology Authors: Li-Hua Dong Jing-Jing Huang Jing Liu Xue Gao Jian-Wei DU Yu-Fu Li Source Type: research

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines
Neoplasia. 2021 May;23(5):539-550. doi: 10.1016/j.neo.2021.03.003. Epub 2021 May 7.ABSTRACTBurkitt's lymphoma (BL) is a highly aggressive form of B-cell non-Hodgkin's lymphoma. The clinical outcome in children with BL has improved over the last years but the prognosis for adults is still poor, highlighting the need for novel treatment strategies. Here, we report that the combinational treatment with the Smac mimetic BV6 and TRAIL triggers necroptosis in BL when caspases are blocked by zVAD.fmk (TBZ treatment). The sensitivity of BL cells to TBZ correlates with MLKL expression. We demonstrate that necroptotic signaling crit...
Source: Neoplasia - May 10, 2021 Category: Cancer & Oncology Authors: Annkathrin Koch Birte Jeiler Jens Roedig Sjoerd J L van Wijk Nadezda Dolgikh Simone Fulda Source Type: research

SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma.
Authors: Zhang R, Zhu H, Yuan Y, Wang Y, Tian Z Abstract The main purpose of the present study was to elucidate the role of sperm‑associated antigen 6 (SPAG6) in the occurrence and development of Burkitt lymphoma (BL) and explore the underlying molecular mechanisms. A correlation was observed between the expression of SPAG6 and the prognosis of patients with lymphoma using The Cancer Genome Atlas (TCGA) database analysis. It was demonstrated that the levels of SPAG6 in BL cells were higher compared with that in IM‑9 cells by reverse transcription‑PCR and western blot assays. Moreover, silencing of SPAG6 sig...
Source: Oncology Reports - October 3, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MiR-29 silencing modulates the expression of target genes related to proliferation, apoptosis and methylation in Burkitt lymphoma cells
ConclusionsOur results suggest a significant role for miR-29s in BL pathogenesis in altering the expression of targets involved in critical cancer pathways, such as cell cycle control, apoptosis inhibition and DNA methylation. Moreover, methylation-mediated miR-29 epigenetic silencing may occur during BL development.
Source: Journal of Cancer Research and Clinical Oncology - January 9, 2018 Category: Cancer & Oncology Source Type: research

Abstract 3617: Inhibition of KLF4 expression in resistant B-NHL cell lines inhibited cell growth and sensitized the cells to drug-induced apoptosis
In conclusion, the overexpression of KLF4 may be responsible, in part, in the pathogenesis, malignancy, and drug resistance of B-NHL lymphomas. In addition, the present findings suggest that the chemical inhibition of KLF4 by Kenpaullone treatment or the inhibition of YY1 may be considered as targets for therapeutic intervention in the treatment of B-lymphoma overexpressing KLF4, when used alone or in combination with sub-toxic chemo/immune-drugs. Current studies are evaluating the role of KLF4 inhibition in vivo using B-NHL tumor xenografts models.Citation Format: Mayra R. Montecillo-Aguado, Gabriel G. Vega, Hector Mayani...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Montecillo–Aguado, M. R., Vega, G. G., Mayani, H., Huerta–Yepez, S., Hernandez–Pando, R., Martinez–Maza, O., Bonavida, B., Vega, M. I. Tags: Experimental and Molecular Therapeutics Source Type: research

Histone deacetylase 6 activity is critical for the metastasis of Burkitt¿s lymphoma cells
Conclusions: We identified a critical role of HDAC6 in the metastasis of Burkitt?s lymphoma cells, suggesting that pharmacological inhibition of HDAC6 could be a promising strategy for the management of metastatic Burkitt?s lymphoma.
Source: Cancer Cell International - December 5, 2014 Category: Cancer & Oncology Authors: Ning DingLingyan PingLixia FengXiaohui ZhengYuqin SongJun Zhu Source Type: research