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Total 4670 results found since Jan 2013.
Efficacy and safety of proxalutamide (GT0918) in severe or critically ill patients with COVID-19: study protocol for a prospective, open-label, single-arm, single-center exploratory trial
This study was registered on 18 June 2022 at the Chinese Clinical Trial Registry (ChiCTR2200061250).PMID:37322522 | PMC:PMC10268455 | DOI:10.1186/s40360-023-00678-7
Source: BMC Pharmacology and Toxicology - June 15, 2023 Category: Drugs & Pharmacology Authors: Dawei Yang Minjie Ju Hao Wang Yichen Jia Xiaodan Wang Hao Fang Jia Fan Source Type: research
Bilateral acute anterior uveitis and optic nerve edema as a manifestation of coronavirus disease ‐2019 (COVID‐19): A case report
The objective of this study was to show that acute anterior uveitis and optic disk edema could be possible manifestations of COVID-19 infection. The patient was a nine-year-old girl presenting with prolonged fever, myalgia, cough, diarrhea, and skin rashes. She also reported blurred vision, Photophobia, and eye redness. PCR test for COVID-19 returned positive. Imaging investigations showed pleural and pericardial effusion, mediastinal lymphadenopathy, and heart valve regurgitation. She was diagnosed with MIS-C and treated with methylprednisolone and IVIG. Bilateral acute anterior uveitis and optic disk edema was detected b...
Source: Clinical Case Reports - June 8, 2023 Category: General Medicine Authors: Aria Mohamadzadeh,
Dena Mohamadzadeh Tags: CASE REPORT Source Type: research
A comprehensive review of COVID-19 detection with machine learning and deep learning techniques
ConclusionIn conclusion, it is evident that ML/DL models have made significant progress in recent years, but there are still limitations that need to be addressed. Overfitting is one such limitation that can lead to incorrect predictions and overburdening of the models. The research community must continue to work towards finding ways to overcome these limitations and make machine and deep learning models even more effective and efficient. Through this ongoing research and development, we can expect even greater advances in the future.
Source: Health and Technology - June 7, 2023 Category: Information Technology Source Type: research
Identification of an immunodominant neutralizing epitope of porcine Deltacoronavirus spike protein
Int J Biol Macromol. 2023 Jun 3:125190. doi: 10.1016/j.ijbiomac.2023.125190. Online ahead of print.ABSTRACTPorcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that, because of its broad host range, poses a potential threat to public health. Here, to identify the neutralizing B-cell epitopes within the S1-CTD protein, we generated three anti-PDCoV monoclonal antibodies (mAbs). Of these, the antibody designated 4E-3 effectively neutralized PDCoV with an IC50 of 3.155 μg/mL. mAb 4E-3 and one other, mAb 2A-12, recognized different linear B-cell epitopes. The minimal fragment recognized by mAb 4E-3 w...
Source: International Journal of Biological Macromolecules - June 5, 2023 Category: Biochemistry Authors: Rui Chen Yimin Wen Enbo Yu Junpeng Yang Yixiao Liang Daili Song Yiping Wen Rui Wu Qin Zhao Senyan Du Qigui Yan Xinfeng Han Sanjie Cao Xiaobo Huang Source Type: research
Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic
ConclusionThe results showed that the R_MFOG is a potential marker for showing the symptom severity of PTSD-MDD comorbidity. Consequently, PTSD-MDD may have reduced BEN in frontal and basal ganglia regions which are related to emotional dysregulation and cognitive deficits.
Source: Frontiers in Psychiatry - June 2, 2023 Category: Psychiatry Source Type: research
EPH43 Potential Association of Remdesivir and Hyperkalemia: A Disproportionality Analysis in USFDA Adverse Event Reporting System Database
Signal detection is one of the most advanced and promising techniques in the world of pharmacovigilance. Remdesivir is approved for emergency use by the US Food and Drug Administration (FDA) for patients with coronavirus disease 2019 (COVID-19). Its benefit- risk ratio is still being explored because data in the field are rather scant. On the other hand hyperkalemia is a potentially life-threatening electrolyte disorder. Severe hyperkalemia can occur suddenly and can cause life-threatening heart rhythm changes (arrhythmia) that cause a heart attack.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: A. Das, M. Vajapu Source Type: research
