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Specialty: Biomedical Science

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Total 5325 results found since Jan 2013.

CT features and outcomes of newly developed pulmonary lesions in patients with Coronavirus Disease 2019 (COVID-19).
Conclusion: During treatment, most patients with COVID-19 pneumonia will develop new pulmonary lesions, which usually manifest as multiple GGOs distributed around the primary lesions or in previously uninvolved lobes, and are subsequently absorbed directly. PMID: 32922203 [PubMed - in process]
Source: International Journal of Medical Sciences - September 16, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Coronavirus Disease 2019 versus Influenza A in Children: An Observational Control Study in China.
This study aimed to understand the differences in clinical, epidemiological, and laboratory features between the new coronavirus disease 2019 (COVID-2019) and influenza A in children. Data of 23 hospitalized children with COVID-19 (9 boys, 5.7 ± 3.8 years old) were compared with age- and sex-matched 69 hospitalized and 69 outpatient children with influenza A from a hospital in China. The participants' epidemiological history, family cluster, clinical manifestations, and blood test results were assessed. Compared with either inpatients or outpatients with influenza A, children with COVID-19 showed significantly more freque...
Source: Biomedical and Environmental Sciences : BES - August 19, 2020 Category: Biomedical Science Authors: Zhao Y, Sun L, Bouchard HC, Zhang XX, Wan G, Hao YW, He SX, Jiang YY, Pang L Tags: Biomed Environ Sci Source Type: research

Investigating the mechanism of ShuFeng JieDu capsule for the treatment of novel Coronavirus pneumonia (COVID-19) based on network pharmacology.
Authors: Chen X, Yin YH, Zhang MY, Liu JY, Li R, Qu YQ Abstract ShuFeng JieDu capsule (SFJDC), a traditional Chinese medicine, has been recommended for the treatment of COVID-19 infections. However, the pharmacological mechanism of SFJDC still remains vague to date. The active ingredients and their target genes of SFJDC were collected from TCMSP. COVID-19 is a type of Novel Coronavirus Pneumonia (NCP). NCP-related target genes were collected from GeneCards database. The ingredients-targets network of SFJDC and PPI networks were constructed. The candidate genes were screened by Venn diagram package for enrichment an...
Source: International Journal of Medical Sciences - October 9, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

The association between subjective impact and the willingness to adopt healthy dietary habits after experiencing the outbreak of the 2019 novel coronavirus disease (COVID-19): a cross-sectional study in China.
Abstract To investigate the associations between subjective perception of impacts and willingness to change dietary habits in China after experiencing the outbreak of the 2019 novel coronavirus disease (COVID-19), an online questionnaire survey was carried out and 22,459 respondents in mainland China participated in the study, with an average age of 27.9±7.8 years old. Of them, 84.5% self-reported epidemic concern (middle or above), and 60.2%, 66.3% and 66.8% self-reported impact (middle or above) on psychology, life, work respectively. 31.9%, 46.0% and 41.0% of respondents reported their willingness to reduce th...
Source: Aging - November 5, 2020 Category: Biomedical Science Authors: Xu Y, Li Z, Yu W, He X, Ma Y, Cai F, Liu Z, Zhao R, Wang D, Guo YF, Chen J Tags: Aging (Albany NY) Source Type: research

Identification of a repurposed drug as an inhibitor of Spike protein of human coronavirus SARS-CoV-2 by computational methods.
Abstract Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is an emerging new viral pathogen that causes severe respiratory disease. SARS-CoV-2 is responsible for the outbreak of COVID-19 pandemic worldwide. As there are no confirmed antiviral drugs or vaccines currently available for the treatment of COVID-19, discovering potent inhibitors or vaccines are urgently required for the benefit of humanity. The glycosylated Spike protein (S-protein) directly interacts with human angiotensin-converting enzyme 2 (ACE2) receptor through the receptor-binding domain (RBD) of S-protein. As the S-protein is exposed t...
Source: Journal of Biosciences - November 18, 2020 Category: Biomedical Science Authors: Unni S, Aouti S, Thiyagarajan S, Padmanabhan B Tags: J Biosci Source Type: research

Association between ageing population, median age, life expectancy and mortality in coronavirus disease (COVID-19).
This study illustrated that COVID-19 mortality was positively associated with ageing population, median age, and life expectancy at birth. PMID: 33232270 [PubMed - as supplied by publisher]
Source: Aging - November 24, 2020 Category: Biomedical Science Authors: Wang XQ, Song G, Yang Z, Chen RJ, Zheng YL, Hu HY, Su X, Chen PJ Tags: Aging (Albany NY) Source Type: research

Kallikrein 13 serves as a priming protease during infection by the human coronavirus HKU1.
Abstract Human coronavirus HKU1 (HCoV-HKU1) is associated with respiratory disease and is prevalent worldwide, but an in vitro model for viral replication is lacking. An interaction between the coronaviral spike (S) protein and its receptor is the primary determinant of tissue and host specificity; however, viral entry is a complex process requiring the concerted action of multiple cellular elements. Here, we found that the protease kallikrein 13 (KLK13) was required for the infection of human respiratory epithelial cells and was sufficient to mediate the entry of HCoV-HKU1 into nonpermissive RD cells. We also dem...
Source: Science Signaling - November 24, 2020 Category: Biomedical Science Authors: Milewska A, Falkowski K, Kulczycka M, Bielecka E, Naskalska A, Mak P, Lesner A, Ochman M, Urlik M, Diamandis E, Prassas I, Potempa J, Kantyka T, Pyrc K Tags: Sci Signal Source Type: research

Establishment of a Nationwide Korean Imaging Cohort of Coronavirus Disease 2019.
CONCLUSION: The KICC-19 was successfully established and comprised of 658 CT scans and 1,475 chest radiographs of 522 hospitalized Korean COVID-19 patients. The KICC-19 will provide a more comprehensive understanding of the clinical, epidemiological, and radiologic characteristics of patients with COVID-19. PMID: 33258333 [PubMed - in process]
Source: Journal of Korean Medical Science - December 3, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

The Impact of the Coronavirus Disease-2019 Pandemic on Childhood Obesity and Vitamin D Status.
CONCLUSION: Within 6 months, increased childhood obesity and vitamin D deficiencies were observed. The duration of school closure was significantly associated with an increased BMI and being normoweight does not exclude the risks for gaining weight. PMID: 33463095 [PubMed - in process]
Source: Journal of Korean Medical Science - January 20, 2021 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Variational-LSTM autoencoder to forecast the spread of coronavirus across the globe
by Mohamed R. Ibrahim, James Haworth, Aldo Lipani, Nilufer Aslam, Tao Cheng, Nicola Christie Modelling the spread of coronavirus globally while learning trends at global and country levels remains crucial for tackling the pandemic. We introduce a novel variational-LSTM Autoencoder model to predict the spread of coronavirus for each country across the globe. This deep Spatio-temporal model does not only rely on historical data of the virus spread but also includes factors related to urban characteristics represented in locational and demographic data (such as population density, urban population, and fertility rate), an in...
Source: PLoS One - January 28, 2021 Category: Biomedical Science Authors: Mohamed R. Ibrahim Source Type: research

Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection induces dysregulation of immunity: in silico gene expression analysis.
Authors: Wu YH, Yeh IJ, Phan NN, Yen MC, Liu HL, Wang CY, Hsu HP Abstract Highly pathogenic coronaviruses (CoVs) induce acute respiratory distress syndrome, and the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused a pandemic since late 2019. The diversity of clinical manifestations after SARS-CoV-2 infection results in great challenges to diagnose CoV disease 2019 (COVID-19). There is a growing body of published research on this topic; however, effective medications are still undergoing a long process of being assessed. In the search for potential genetic targets for this infection, we applied ...
Source: International Journal of Medical Sciences - February 3, 2021 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Coronavirus risk perception and compliance with social distancing measures in a sample of young adults: Evidence from Switzerland
by Axel Franzen, Fabienne W öhner The health risk of the coronavirus pandemic is age-specific. The symptoms of a COVID-19 infection are usually mild in the healthy population below the age of 65; however, the measures laid down to prevent the spread of the virus apply typically to the whole population. Hence, those who have a low risk of severe symptoms face a social dilemma in cooperating and complying with the safety measures: Cooperating in preventing the spread of the disease is good for society but comes with individual costs. These costs provide an incentive not to cooperate with the safety measures. In this paper ...
Source: PLoS One - February 19, 2021 Category: Biomedical Science Authors: Axel Franzen Source Type: research

Monitoring peripheral neutrophil and T-lymphocyte subsets could assist in differentiating the severity and disease progression of coronavirus disease 2019
This study retrospectively explored the clinical significance of peripheral lymphocytes, especially the dynamic analysis of T-cell subsets, in determining coronavirus disease 2019 (COVID-19) severity and progression. Seventy-nine patients with COVID-19 in the Public Health Clinical Center of Chengdu from January to February 2020 were included, 59 of which were analyzed for dynamic peripheral T-cell subsets expression. The neutrophil to CD4+ T lymphocyte ratio (N4R) and neutrophil to CD3+ T lymphocyte ratio (N3R) showed clinical significance in differentiating severe or critically-severe COVID-19, with area under receiver o...
Source: Aging - March 20, 2021 Category: Biomedical Science Authors: Liye Meng Jiao Xu Junlong Zhang Keyi Zhang Pengcheng Shang Qingfeng Li Yi Li Lanlan Wang Bei Cai Source Type: research

Adverse Events Following Immunization Associated with Coronavirus Disease 2019 Vaccination Reported in the Mobile Vaccine Adverse Events Reporting System
CONCLUSION: The AEFIs associated with the ChAdOx1 nCoV-19 vaccine were tolerable, and the use of the MVAERS was helpful in monitoring the AEFIs. The use of MVAERS will help in sharing accurate and ample information about vaccination against COVID-19.PMID:33942578 | DOI:10.3346/jkms.2021.36.e114
Source: Journal of Korean Medical Science - May 4, 2021 Category: Biomedical Science Authors: Minji Jeon Jehun Kim Chi Eun Oh Jin Young Lee Source Type: research