Filtered By:
Specialty: Biomedical Science
This page shows you your search results in order of relevance. This is page number 11.
Order by Relevance | Date
Total 5325 results found since Jan 2013.
How We Have Treated Severe to Critically Ill Patients With Coronavirus Disease 2019 in Korea
J Korean Med Sci. 2022 Dec 19;37(49):e353. doi: 10.3346/jkms.2022.37.e353.ABSTRACTSince 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and the coronavirus disease 2019 (COVID-19) pandemic currently continues. In response to this unprecedented pandemic, several researchers and medical staff have struggled to find appropriate treatments for COVID-19. Patients with mild symptoms can recuperate with symptomatic care, however establishing treatment for severe to critically ill patients who can have a high mortality has been essential. Accordingly, the guidelines for COVID-19 treatme...
Source: Journal of Korean Medical Science - December 20, 2022 Category: Biomedical Science Authors: Do Hyeon Park Chang Kyung Kang Pyoeng Gyun Choe Nam Joong Kim Wan Beom Park Myoung-Don Oh Source Type: research
Numerical Analysis of Coronavirus Detection Using Photonic Crystal Fibre –Based SPR Sensor
AbstractCoronavirus disease (COVID-19) is a worldwide health emergency caused by the coronavirus 2 (severe acute respiratory illness) (SARS-CoV-2). COVID-19 has a wide range of symptoms, making a definitive diagnosis difficult. The shortage of equipment for testing technology COVID-19 has resulted in long queues for COVID-19 testing, which is a major problem. COVID-19 testing is currently performed using sluggish and costly technology like single-photon emission computed tomography (SPECT), computed tomography (CT), positron emission tomography (PET), and enzyme-linked immunosorbent assay (ELISA). The gold standard test fo...
Source: Plasmonics - January 24, 2023 Category: Biomedical Science Source Type: research
Laboratory Investigation and Phylogenetic Analysis of an Imported Middle East Respiratory Syndrome Coronavirus Case in Greece
by Athanasios Kossyvakis, Ying Tao, Xiaoyan Lu, Vasiliki Pogka, Sotirios Tsiodras, Mary Emmanouil, Andreas F. Mentis, Suxiang Tong, Dean D. Erdman, Antonios Antoniadis
Rapid and reliable laboratory diagnosis of persons suspected of Middle East respiratory syndrome coronavirus (MERS-CoV) infection is important for timely implementation of infection control practices and disease management. In addition, monitoring molecular changes in the virus can help elucidate chains of transmission and identify mutations that might influence virus transmission efficiency. This was illustrated by a recent laboratory investigation we cond...
Source: PLoS One - April 28, 2015 Category: Biomedical Science Authors: Athanasios Kossyvakis et al. Source Type: research
The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus < i > Beaudette < /i > Strain
In this study, we biochemically fractionated IBV-infected cells via sucrose density gradient centrifugation after depleting plasma membrane cholesterol with methyl-β-cyclodextrin or Mevastatin. Our results demonstrated that unlike IBV non-structural proteins, IBV structural proteins co-localized with lipid raft marker caveolin-1. Infectivity assay results of Vero cells illustrated that the drug-induced disruption of lipid rafts significantly suppressed IBV infection. Further studies revealed that lipid rafts were not required for IBV genome replication or virion release at later stages. However, the drug-mediated depletio...
Source: PLoS One - January 11, 2017 Category: Biomedical Science Authors: Huichen Guo Source Type: research
Microglia are required for protection against lethal coronavirus encephalitis in mice
Recent findings have highlighted the role of microglia in orchestrating normal development and refining neural network connectivity in the healthy CNS. Microglia are not only vital cells in maintaining CNS homeostasis, but also respond to injury, infection, and disease by undergoing proliferation and changes in transcription and morphology. A better understanding of the specific role of microglia in responding to viral infection is complicated by the presence of nonmicroglial myeloid cells with potentially overlapping function in the healthy brain and by the rapid infiltration of hematopoietic myeloid cells into the brain ...
Source: Journal of Clinical Investigation - January 30, 2018 Category: Biomedical Science Authors: D. Lori Wheeler, Alan Sariol, David K. Meyerholz, Stanley Perlman Source Type: research
Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus
Middle East respiratory syndrome coronavirus (MERS-CoV) consists of a positive-sense, single-stranded RNA genome and four structural proteins: the spike, envelope, membrane, and nucleocapsid protein. The assem...
Source: Journal of Biomedical Science - May 24, 2018 Category: Biomedical Science Authors: Wei-Chen Hsin, Chan-Hua Chang, Chi-You Chang, Wei-Hao Peng, Chung-Liang Chien, Ming-Fu Chang and Shin C. Chang Tags: Research Source Type: research
IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available. The Middle East respiratory syndrome–coronavirus (MERS-CoV) is such an infection, yet little is known about the role of IFN-I in this setting. Here, we show that IFN-I signaling is protective during MERS-CoV infection. Blocking IFN-I signaling resulted in delayed virus clearance, enhanced neutrophil infiltration, and impaired MERS-CoV–specific T cell responses. Notably, ...
Source: Journal of Clinical Investigation - July 29, 2019 Category: Biomedical Science Authors: Rudragouda Channappanavar, Anthony R. Fehr, Jian Zheng, Christine Wohlford-Lenane, Juan E. Abrahante, Matthias Mack, Ramakrishna Sompallae, Paul B. McCray Jr., David K. Meyerholz, Stanley Perlman Source Type: research
The human coronavirus HCoV ‐229E S‐protein structure and receptor binding
The coronavirus S-protein mediates receptor binding and fusion of the viral and host cell membranes. In HCoV-229E, its receptor binding domain (RBD) shows extensive sequence variation but how S-protein function is maintained is not understood. Reported are the X-ray crystal structures of Class III-V RBDs in complex with human aminopeptidase N (hAPN), as well as the electron cryomicroscopy structure of the 229E S-protein. The structures show that common core interactions define the specificity for hAPN and that the peripheral RBD sequence variation is accommodated by loop plasticity. The results provide insight into immune ...
Source: eLife - October 25, 2019 Category: Biomedical Science Tags: Biochemistry and Chemical Biology Source Type: research
The Outbreak Cases with the Novel Coronavirus Suggest Upgraded Quarantine and Isolation in Korea.
Authors: Yoo JH, Hong ST
PMID: 32030926 [PubMed - in process]
Source: Journal of Korean Medical Science - February 8, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
The Author's Response: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR.
Authors: Lim J, Jeon S, Shin HY, Kim MJ, Seong YM, Lee WJ, Choe KW, Kang YM, Lee B, Park SJ
PMID: 32080993 [PubMed - in process]
Source: Journal of Korean Medical Science - February 22, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Letter to the Editor: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR.
Authors: Kim JY
PMID: 32080992 [PubMed - in process]
Source: Journal of Korean Medical Science - February 22, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Will the Third Wave of Coronavirus Disease 2019 Really Come in Korea?
Authors: Yoo JH
PMID: 32174068 [PubMed - in process]
Source: Journal of Korean Medical Science - March 18, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Understanding and Interpretation of Case Fatality Rate of Coronavirus Disease 2019.
Authors: Kim DH, Choe YJ, Jeong JY
PMID: 32233163 [PubMed - in process]
Source: Journal of Korean Medical Science - April 2, 2020 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
How to reduce the likelihood of coronavirus-19 (CoV-19 or SARS-CoV-2) infection and lung inflammation mediated by IL-1.
Authors: Conti P, Gallenga CE, Tetè G, Caraffa A, Ronconi G, Younes A, Toniato E, Ross R, Kritas SK
Abstract
SARS-CoV-2, also referred to as CoV-19, is an RNA virus which can cause severe acute respiratory diseases (COVID-19), with serious infection of the lower respiratory tract followed by bronchitis, pneumonia and fibrosis. The severity of the disease depends on the efficiency of the immune system which, if it is weak, cannot stem the infection and its symptoms. The new CoV-19 spreads in the population at a rate of 0.8-3% more than normal flu and mostly affects men, since immune genes are more expressed on the ...
Source: Journal of Biological Regulators and Homeostatic Agents - April 2, 2020 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
