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Evaluation of T-cell subsets in pregnant women infected with SARS-CoV-2
CONCLUSION: The CD3+ total T cell (p = 0.001), CD3+CD4+ helper T cell (p = 0.011), Treg (p = 0.001), and Treg/Th17 ratio (p = 0.001) were found to be lower in pregnant women infected with SARS-CoV-2. This difference was associated with the development of pneumonia but not with adverse pregnancy outcomes.PMID:37633234 | DOI:10.1016/j.intimp.2023.110798
Source: International Immunopharmacology - August 26, 2023 Category: Allergy & Immunology Authors: M Kulhan H Ozdemir A Bilgi C Celik N Aktug Demir H Turk Dagi M G Ucar N G Kulhan H Artac Source Type: research

Predictors of incomplete COVID-19 vaccine schedule among adults in Scotland: Two retrospective cohort analyses of the primary schedule and third dose
CONCLUSION: We observed several risk factors that predict incomplete COVID-19 vaccination schedule. Vaccination programmes must take immediate action to ensure maximum uptake, particularly for populations vulnerable to severe COVID-19 outcomes.PMID:37598025 | DOI:10.1016/j.vaccine.2023.07.070
Source: Vaccine - August 19, 2023 Category: Allergy & Immunology Authors: Kirsty Morrison Lucy Cullen Allan B James Vera Chua Christopher Sullivan Chris Robertson Jade Carruthers Rachael Wood Karen Jeffrey Calum MacDonald Syed Ahmar Shah Igor Rudan Colin R Simpson Colin McCowan Srinivasa Vittal Katikireddi Zoe Grange Lewis Ritc Source Type: research

Exclusion of pregnant people from emergency vaccine clinical trials: A systematic review of clinical trial protocols and reporting from 2009 to 2019
CONCLUSION: Pregnant people are underrepresented in vaccine clinical trials conducted during outbreaks, resulting in underreporting of pregnancy-related outcomes and a lack of protection for pregnant people and neonates from infectious diseases.PMID:37442686 | DOI:10.1016/j.vaccine.2023.06.073
Source: Vaccine - July 13, 2023 Category: Allergy & Immunology Authors: Jamie Minchin Gavin H Harris Sasha Baumann Emily R Smith Source Type: research

A unique maternal and placental galectin signature upon SARS-CoV-2 infection suggests galectin-1 as a key alarmin at the maternal –fetal interface
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic imposed a risk of infection and disease in pregnant women and neonates. Successful pregnancy requires a fine-tuned regulation of the maternal immune system to accommodate the growing fetus and to protect the mother from infection. Galectins, a family of β-galactoside–binding proteins, modulate immune and inflammatory processes and have been recognized as critical factors in reproductive orchestration, including maternal immune adaptation in pregnancy. Pregnancy-specific glycoprotein 1 (PSG1) is a recently identified gal-1 ligand at the maternal–...
Source: Frontiers in Immunology - July 5, 2023 Category: Allergy & Immunology Source Type: research

Cord blood antibodies following BBIBP ‐CorV (Sinopharm) vaccination during pregnancy
ConclusionThere was a significant correlation between maternal and neonatal IgG concentrations. Although, receiving both doses of the BBIBP-CorV vaccine (not 1 dose) during pregnancy is highly beneficial for increasing humoral immunity for the mother and fetus.
Source: Immunity, Inflammation and Disease - June 14, 2023 Category: Allergy & Immunology Authors: Sedigheh Hantoushzadeh, Nasim Eshraghi, Sarang Younesi, Mohammadreza Salehi, Nima Rezaei, Mohammad Mehdi Hasheminejad, Pegah Rashidian, Saeedeh Shirdel, Fatemeh Asadi, Marjan Ghaemi Tags: ORIGINAL ARTICLE Source Type: research

Post-vaccination SARS-CoV-2 seroprevalence in children aged 3-11 years and the positivity in unvaccinated children: A retrospective, single-center study
ConclusionsInactivated SARS-CoV-2 vaccines could induce robust humoral immune response that gradually declined within several months after the second dose. Therefore, it helps to determine whether children receive a booster dose and elicit a long-term memory immune response. Positive SARS-CoV-2 antibodies in unvaccinated children were associated with passive IgG antibody infusion.
Source: Frontiers in Immunology - November 7, 2022 Category: Allergy & Immunology Source Type: research

Labor Could Increase Systemic Inflammation and Cause or Deteriorate Cytokine Storm in COVID-19
Iran J Immunol. 2022 Sep;19(3):330-336. doi: 10.22034/iji.2022.93951.2267.ABSTRACTPregnant women with coronavirus disease 2019 (COVID-19) have a higher risk of morbidity and mortality compared with the general population. Possible pathways are: I) in patients with COVID-19, cytokine storm defined as the excess release of pro-inflammatory cytokines such as interleukin 1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) has been associated with morbidities and an even higher rate of mortality. II) Labor, despite being a term/preterm, has an inflammatory nature, although, inflammation is more prominent in preterm delive...
Source: Iranian Journal of Immunology - October 3, 2022 Category: Allergy & Immunology Authors: Amir Hossein Norooznezhad Alireza A Shamshirsaz Sedigheh Hantoushzadeh Source Type: research

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