The Effects of Disease-Modifying Therapies on Oxidative Stress in Patients With Relapsing-Remitting Multiple Sclerosis
Objective
Oxidative stress (OS) has a role in the pathogenesis and progression of multiple sclerosis. The effects of disease-modifying therapies (DMTs) on OS are unclear. We aimed to explore the association between DMTs and OS in patients with relapsing-remitting multiple sclerosis (RRMS).
Methods
The study conducted in 167 patients (102 received and 65 not received the DMTs). The DMTs included interferon beta-1a (n = 15), interferon beta-1b (n = 20), glatiramer acetate (n = 10), and sphingosine-1-phosphate receptor modulators (n = 57). Oxidative stress assessed by total antioxidant status (TAS) and total oxidan...
Source: Clinical Neuropharmacology - November 1, 2022 Category: Neurology Tags: Original Articles Source Type: research
Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFN β-1a biologics
In this study with 36 healthy participants randomized to therapeutic doses of interferon-beta 1a products (IFNβ-1a) or pegylated-IFNβ-1a [pegIFNβ-1a]) approved to treat multiple sclerosis or placebo, we evaluated the utility of a proteomic assay that profiles >7000 plasma proteins. IFNβ-1a and pegIFNβ-1a resulted in 248 and 528 differentially expressed protein analytes respectively, between treatment and placebo groups over the time course. Thirty-one proteins were prioritized based on a maximal fold change ≥2 from baseline, baseline adjusted area under the effect curve (AUEC) and overlap between the two products...
Source: Clinical Pharmacology and Therapeutics - October 29, 2022 Category: Drugs & Pharmacology Authors: Paula L Hyland Lakshmi Manasa S Chekka Deepti P Samarth Barry A Rosenzweig Erica Decker Esraa G Mohamed Yan Guo Murali K Matta Qin Sun William Wheeler Carlos Sanabria James L Weaver Sarah J Schrieber Jeffry Florian Yow-Ming Wang David G Strauss Source Type: research
Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFN β-1a biologics
In this study with 36 healthy participants randomized to therapeutic doses of interferon-beta 1a products (IFNβ-1a) or pegylated-IFNβ-1a [pegIFNβ-1a]) approved to treat multiple sclerosis or placebo, we evaluated the utility of a proteomic assay that profiles >7000 plasma proteins. IFNβ-1a and pegIFNβ-1a resulted in 248 and 528 differentially expressed protein analytes respectively, between treatment and placebo groups over the time course. Thirty-one proteins were prioritized based on a maximal fold change ≥2 from baseline, baseline adjusted area under the effect curve (AUEC) and overlap between the two products...
Source: Clinical Pharmacology and Therapeutics - October 29, 2022 Category: Drugs & Pharmacology Authors: Paula L Hyland Lakshmi Manasa S Chekka Deepti P Samarth Barry A Rosenzweig Erica Decker Esraa G Mohamed Yan Guo Murali K Matta Qin Sun William Wheeler Carlos Sanabria James L Weaver Sarah J Schrieber Jeffry Florian Yow-Ming Wang David G Strauss Source Type: research
Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFN β-1a biologics
In this study with 36 healthy participants randomized to therapeutic doses of interferon-beta 1a products (IFNβ-1a) or pegylated-IFNβ-1a [pegIFNβ-1a]) approved to treat multiple sclerosis or placebo, we evaluated the utility of a proteomic assay that profiles >7000 plasma proteins. IFNβ-1a and pegIFNβ-1a resulted in 248 and 528 differentially expressed protein analytes respectively, between treatment and placebo groups over the time course. Thirty-one proteins were prioritized based on a maximal fold change ≥2 from baseline, baseline adjusted area under the effect curve (AUEC) and overlap between the two products...
Source: Clinical Pharmacology and Therapeutics - October 29, 2022 Category: Drugs & Pharmacology Authors: Paula L Hyland Lakshmi Manasa S Chekka Deepti P Samarth Barry A Rosenzweig Erica Decker Esraa G Mohamed Yan Guo Murali K Matta Qin Sun William Wheeler Carlos Sanabria James L Weaver Sarah J Schrieber Jeffry Florian Yow-Ming Wang David G Strauss Source Type: research
Evaluating the Utility of Proteomics for the Identification of Circulating Pharmacodynamic Biomarkers of IFN β-1a biologics
In this study with 36 healthy participants randomized to therapeutic doses of interferon-beta 1a products (IFNβ-1a) or pegylated-IFNβ-1a [pegIFNβ-1a]) approved to treat multiple sclerosis or placebo, we evaluated the utility of a proteomic assay that profiles >7000 plasma proteins. IFNβ-1a and pegIFNβ-1a resulted in 248 and 528 differentially expressed protein analytes respectively, between treatment and placebo groups over the time course. Thirty-one proteins were prioritized based on a maximal fold change ≥2 from baseline, baseline adjusted area under the effect curve (AUEC) and overlap between the two products...
Source: Clinical Pharmacology and Therapeutics - October 29, 2022 Category: Drugs & Pharmacology Authors: Paula L Hyland Lakshmi Manasa S Chekka Deepti P Samarth Barry A Rosenzweig Erica Decker Esraa G Mohamed Yan Guo Murali K Matta Qin Sun William Wheeler Carlos Sanabria James L Weaver Sarah J Schrieber Jeffry Florian Yow-Ming Wang David G Strauss Source Type: research
Predictors of Disease Activity and Worsening in Relapsing-Remitting Multiple Sclerosis
Discussion
Prospective data from a large clinical trial cohort show that younger MS patients with high BL relapses and MRI lesion burden have the highest risk of subsequent disease activity.
Trial Registration Information
Clinical trial registration number NCT00211887. CombiRx was registered at ClinicalTrials.gov (NCT00211887) on September 21, 2005. Study enrollment began in January 2005. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - August 9, 2022 Category: Neurology Authors: Zhang, Y., Cofield, S., Cutter, G., Krieger, S., Wolinsky, J. S., Lublin, F. Tags: MRI, Prognosis, All Clinical trials, Multiple sclerosis Research Article Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
