The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
The Role of Cobalamin on Interleukin 10, Osteopontin, and Related MicroRNAs in Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):332-343. doi: 10.18502/ijaai.v21i3.9806.ABSTRACTMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). Considering how vitamin B12 or cobalamin affects the immune system, especially inflammation and the formation of the myelin sheath, it appears as a complementary therapy for MS by affecting some signaling pathways. Recently diagnosed MS patients were divided into two groups (n=30). One group received interferon-beta (IFN-β or Avonex), and another received IFN-β+B12 for six months. Blood samples were taken before and after treatments...
Source: Iranian Journal of Allergy, Asthma and Immunology - July 13, 2022 Category: Allergy & Immunology Authors: Mohammad Sadegh Hesamian Vahid Shaygannejad Marjan Golabi Omid Mirmosayyeb Alireza Andalib Nahid Eskandari Source Type: research
Longitudinal analysis of anti-drug antibody development in multiple sclerosis patients treated with interferon beta-1a (Rebif ™) using B cell receptor repertoire analysis
A significant proportion of multiple sclerosis (MS) patients treated with interferon beta-1a (Rebif ™) develop anti-drug antibodies (ADA) with a negative impact on treatment efficacy. We hypothesized that high-throughput B-cell receptor (BCR) repertoire analysis could be used to predict and monitor ADA development. To study this we analyzed 228 peripheral blood samples from 68 longitudinally fol lowed patients starting on interferon beta-1a. Our results show that whole blood BCR analysis does not reflect, and does not predict ADA development in MS patients treated with interferon beta-1a. (Source: Journal of Neuroimmunology)
Source: Journal of Neuroimmunology - July 12, 2022 Category: Allergy & Immunology Authors: Linda van der Weele, Sabrina Pollastro, Barbera D.C. van Schaik, Antoine H.C. van Kampen, Ilse T.G. Niewold, Taco W. Kuijpers, Clemens Warnke, Poul Erik H. Jensen, Daniel Kramer, Malin Ryner, Christina Hermanrud, Pierre D önnes, Marc Pallardy, Sebastian Source Type: research
A case of Fingolimod-associated Cryptococcal Meningitis
CONCLUSION: Albeit fingolimod associated cryptococcal meningitis is a rare event, Fingolimod therapy in patients with MS should be performed cautiously. Regular follow-ups may give rise to a timely diagnosis of probable fingolimod associated cryptococcal meningitis. Fingolimod therapy can lead to lymphocytopenia and various infections. We; therefore, suggest that intermittent blood lymphocyte counts as well as monitoring of clinical manifestations among MS patients treated with Fingolimod to avoid additional neurological and physical disabilities in these patients.PMID:35770404 | DOI:10.2174/1570162X20666220629124225 (Sour...
Source: Current HIV Research - June 30, 2022 Category: Infectious Diseases Authors: Ilad Alavi Darazam Mohammad Mahdi Rabiei Omid Moradi Farid Javandoust Gharehbagh Mehrdad Roozbeh Ramin Nourinia Firouze Hatami Maziar Shojaei Legha Lotfollahi Source Type: research
A case of Fingolimod-associated Cryptococcal Meningitis
CONCLUSION: Albeit fingolimod associated cryptococcal meningitis is a rare event, Fingolimod therapy in patients with MS should be performed cautiously. Regular follow-ups may give rise to a timely diagnosis of probable fingolimod associated cryptococcal meningitis. Fingolimod therapy can lead to lymphocytopenia and various infections. We; therefore, suggest that intermittent blood lymphocyte counts as well as monitoring of clinical manifestations among MS patients treated with Fingolimod to avoid additional neurological and physical disabilities in these patients.PMID:35770404 | DOI:10.2174/1570162X20666220629124225 (Sour...
Source: Current HIV Research - June 30, 2022 Category: Infectious Diseases Authors: Ilad Alavi Darazam Mohammad Mahdi Rabiei Omid Moradi Farid Javandoust Gharehbagh Mehrdad Roozbeh Ramin Nourinia Firouze Hatami Maziar Shojaei Legha Lotfollahi Source Type: research
