TWiV 754: Tuesday two: SARS-CoV-2 and TLR2
TWiV discusses the finding that the envelope (E) protein of SARS-CoV-2 is sensed by toll-like receptor 2 on cells, leading to the production of inflammatory cytokines that cause damage to cells and tissues in COVID-19. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode ASV vaccine town halls Michelson Prizes FDA authorizes Pfizer/BioNTech mRNA vaccine for adolescents (FDA) TLR2 senses SARS-CoV-2 E protein (Nat Imm) Review on CoV E protein (Virology J) Timestamps by Jolene. Thanks! Weekly Pic...
Source: This Week in Virology - MP3 Edition - May 13, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Coronapod: Waiving vaccine patents and coronavirus genome data disputes
In surprise news this week, the US government announced its support for waiving patent protections for COVID-19 vaccines, in an effort to boost supplies around the world.As fewer than 1% of people living in low-income countries have received COVID-19 vaccines, it is hoped that this move is a major step towards addressing this inequity by allowing manufacturers to legally produce generic versions of vaccines. We discuss the next steps that need to be taken to make this a reality, and why there is opposition to the plan.Also on the podcast, we look at another aspect of coronavirus inequity: the sharing of genomic data. Aroun...
Source: Nature Podcast - May 7, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
Coronapod: Waiving vaccine patents and coronavirus genome data disputes
In surprise news this week, the US government announced its support for waiving patent protections for COVID-19 vaccines, in an effort to boost supplies around the world.As fewer than 1% of people living in low-income countries have received COVID-19 vaccines, it is hoped that this move is a major step towards addressing this inequity by allowing manufacturers to legally produce generic versions of vaccines. We discuss the next steps that need to be taken to make this a reality, and why there is opposition to the plan.Also on the podcast, we look at another aspect of coronavirus inequity: the sharing of genomic data. Aroun...
Source: Nature Podcast - May 7, 2021 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 750: To err is viral
The TWiVmeisters discuss how copy-back defective viral genomes might modulate the clinical outcome of respiratory syncytial virus infection, and detection of antibodies to henipa- and filo-like viruses in Trinidad bats. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Vaccine education town halls (ASV) RSV cpDVG may influence clinical outcome (Nat Micro) Henipa- and filo-like viruses in Trinidad bats (J Inf Dis) Nice image of cpDVG generation Letters read on TWiV 750 Timesta...
Source: This Week in Virology - MP3 Edition - May 2, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 749: COVID-19 clinical update #60 with Dr. Daniel Griffin
In COVID-19 clinical update #60, Daniel Griffin summarizes CDC guidance for summer camps, how to protect yourself when fully vaccinated, updated recommendation for J&J vaccine, declining global case fatality rate, and characterization of post-acute sequelae. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Summer camp guidance (CDC) Protect yourself when fully vaccinated (CDC) Updated recommendation on J&J vaccine (MMWR) NY variant B1.526 (one, two) Declining global CFR (AJTMH) Protease inhibitor in phase I (Pfizer) Mo...
Source: This Week in Virology - MP3 Edition - May 1, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 744: COVID-19 clinical update #58 with Dr. Daniel Griffin
In COVID-19 clinical update #58, Daniel Griffin provides the latest update on the J&J vaccine pause, healthcare worker deaths, children and COVID, physical inactivity associated with higher risk, using monoclonal antibodies for prophylaxis, and shows us how to properly wear a face mask. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Healthcare worker deaths (Guardian) Children and adolescent disease severity (JAMA) Physical inactivity and increased disease risk (BMJ) Expansion of Pfizer/BioNTech EUA (pdf) Thrombosis ...
Source: This Week in Virology - MP3 Edition - April 17, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 739: COVID-19 convalescent plasma with Arturo Casadevall
Arturo Casadevall joins TWiV to discuss the use of convalescent plasma to treat COVID-19, including a history of the process, how plasma is prepared and tested, why it is difficult to conduct randomized clinical trials, how this treatment has fared and his hopes for the future. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Guest: Arturo Casadevall Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Victory for Scientific Pragmatism (New Atlantis) Convalescent plasma levels and risk of COVID-19 death (NEJM) COVID-19 convalescent plasma safety ...
Source: This Week in Virology - MP3 Edition - April 4, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 738: COVID-19 clinical update #56 with Dr. Daniel Griffin
In COVID-19 clinical update #56, Daniel Griffin note increasing hospitalization in children and young adults, Pfizer vaccine efficacy results in 12-15 year olds, rapid self administered nucleic acid and antigen tests, mRNA vaccine efficacy in real world conditions, and improvement of long COVID after vaccination. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Pfizer mRNA vaccine is 100% effective in 12-15 year olds (Pfizer) Cue at-home PCR test receives FDA EUA (Cue) DxTerity COVID-19 saliva nucleic acid at-home test...
Source: This Week in Virology - MP3 Edition - April 3, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
