Fight Aging! Newsletter, April 29th 2024
In conclusion, we assigned stemness scores to human samples and show evidence of a pan-tissue loss of stemness during human aging, which adds weight to the idea that stem cell deterioration may contribute to human aging.
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The Role of Immune Aging in Neurodegenerative Conditions
https://www.fightaging.org/archives/2024/04/the-role-of-immune-aging-in-neurodegenerative-conditions/
The research community has come to see chronic inflammation and other age-related immune system dysfunctions as an important aspect of neurodegenerative conditions. Inflammation in the short term is n...
Source: Fight Aging! - April 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
The market has been in the doldrums and it has been a tough year for fundraising, both for non-profits and biotech startups. The conferences have exhibited more of an academic focus as companies tightened belts and postponed investment rounds, while investors stayed home. Not that this halts the flow of hype for some projects, and nor has it slowed media commentary on the longevity industry as it presently stands. A few of the articles in that commmentary are even interesting to read! The field has grown and is more mature now than has ever been the case. Biotech of all forms is a challenging field with a high failure rate...
Source: Fight Aging! - December 29, 2023 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
What's new in midwifery - 8th December 2023
Guidance and education resourcesRoyal College of Nursing,Genital examination in women: a resource for skills development and assessment (PDF)NHS England,Maternity and neonatal voices partnership guidance, part of theThree year delivery plan for maternity and neonatal services ResearchLabour and childbirthBarriers and facilitators of implementing the practice programme for upright positions in the second stage of labour: A mixed ‐method study Research undertaken in Chinese healthcare settings. Subscription or library access may be needed to see the full text.Impact of discontinuing o...
Source: Browsing - December 8, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Malnutrition Can Impact Wound Healing
Malnutrition can have a significant impact on wound healing. Proper wound healing is a complex process that involves various cellular and biochemical reactions. When the body is malnourished, it lacks the essential nutrients necessary for these processes, which can lead to delayed or impaired wound healing. Here are some key relationships between malnutrition and wound healing:
1. Protein Deficiency: Protein is crucial for tissue repair and the production of collagen, which is essential for wound healing. Malnourishment, especially a lack of adequate protein intake, can lead to a delay in wound closure and reduced tensile ...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - October 2, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Improving Medical Care Jeff Levine MD J Source Type: blogs
What's new in midwifery - research evidence - 12th April 2023
Recent research articles that might be useful to know about.Infant feeding method and special educational need, a cohort study of 191745 Scottish schoolchildren.von Willebrand disease in pregnancy.Another systematic review of COVID vaccination in pregnancy, abstract and link in McMaster ' s Evidence Alerts. Postpartum hypertension, abstract and link in McMaster ' s Evidence Alerts.Safety and immunogenicity of an RSV vaccine in mothers and their infants.Intravenous ketorolac after cesarean, link and abstract in McMaster ' s Evidence Alerts. Induction of labour at or near term for suspected fetal macrosomia - Cochr...
Source: Browsing - April 12, 2023 Category: Databases & Libraries Tags: midwifery Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Postoperative nutritional management among patients with oesophago-gastric cancer in England: NOGCA short report
This report provides insight into current postoperative nutritional practices in ten (27.8 per cent) oesophago-gastric cancer specialist centres across England, based on 617 patients who underwent curative surgery after being diagnosed between April 2019 and March 2020. The report found that, for patients who had oesophagectomy, the most commonly reported nutritional management strategy was enteral nutrition delivered via a jejunostomy during the admission and continued on discharge (51.0 per cent). It also found that the majority of oesophagectomy patients (83.9 per cent) had a jejunostomy or received parenteral nutrition...
Source: Health Management Specialist Library - August 16, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
National survey of malnutrition and nutritional care in adults
This report outlines the findings of a survey that aimed to take the temperature on the status of nutritional care across all health and social care settings in the UK. The survey found that 40 per cent of patients were at risk of malnutrition but also that the majority of patients had a nutritional care plan in place, particularly for those who were at medium or high-risk of malnutrition.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - September 14, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
Fight Aging! Newsletter, August 30th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out mo...
Source: Fight Aging! - August 29, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Malnutrition and nutritional care of Covid-19 patients in hospitals during the first wave of the pandemic
British Association for Parenteral and Enteral Nutrition (BAPEN) - BAPEN undertook a survey of hospital based healthcare professionals to better understand the nutritional care and challenges of patients with Covid-19 they faced during the first wave of the coronavirus pandemic. The survey was designed to investigate challenges in delivering nutritional care in ICU and HDU, and on general wards. It covers issues identifying malnutrition risk, the barriers to delivering good nutritional care on the wards, and nutritional strategies, as well as particular challenges relating to discharge.Survey resultsPress release (So...
Source: Health Management Specialist Library - February 8, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Public health and health inequalities Source Type: blogs
