Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Postoperative nutritional management among patients with oesophago-gastric cancer in England: NOGCA short report
This report provides insight into current postoperative nutritional practices in ten (27.8 per cent) oesophago-gastric cancer specialist centres across England, based on 617 patients who underwent curative surgery after being diagnosed between April 2019 and March 2020. The report found that, for patients who had oesophagectomy, the most commonly reported nutritional management strategy was enteral nutrition delivered via a jejunostomy during the admission and continued on discharge (51.0 per cent). It also found that the majority of oesophagectomy patients (83.9 per cent) had a jejunostomy or received parenteral nutrition...
Source: Health Management Specialist Library - August 16, 2022 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
National survey of malnutrition and nutritional care in adults
This report outlines the findings of a survey that aimed to take the temperature on the status of nutritional care across all health and social care settings in the UK. The survey found that 40 per cent of patients were at risk of malnutrition but also that the majority of patients had a nutritional care plan in place, particularly for those who were at medium or high-risk of malnutrition.ReportPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - September 14, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Quality of care and clinical outcomes Source Type: blogs
Fight Aging! Newsletter, August 30th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out mo...
Source: Fight Aging! - August 29, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens. Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Malnutrition and nutritional care of Covid-19 patients in hospitals during the first wave of the pandemic
British Association for Parenteral and Enteral Nutrition (BAPEN) - BAPEN undertook a survey of hospital based healthcare professionals to better understand the nutritional care and challenges of patients with Covid-19 they faced during the first wave of the coronavirus pandemic. The survey was designed to investigate challenges in delivering nutritional care in ICU and HDU, and on general wards. It covers issues identifying malnutrition risk, the barriers to delivering good nutritional care on the wards, and nutritional strategies, as well as particular challenges relating to discharge.Survey resultsPress release (So...
Source: Health Management Specialist Library - February 8, 2021 Category: UK Health Authors: The King ' s Fund Library Tags: Public health and health inequalities Source Type: blogs
Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest. BMP6 as a Target for Pro-Angiogenic Therapies https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/ Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a p...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected. This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
National survey of malnutrition and nutritional care in adults
British Association for Parenteral and Enteral Nutrition -The purpose of this survey was to gain an understanding of the prevalence of malnutrition according to the Malnutrition Universal Screening Tool ( ‘MUST’), and the use of nutritional care across England, in all settings. The survey recorded a high prevalence of malnutrition (42 per cent), higher than previous national surveys.ReportBritish Association for Parenteral and Enteral Nutrition - news (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - September 21, 2020 Category: UK Health Authors: The King ' s Fund Library Tags: Patient involvement, experience and feedback Patient safety Source Type: blogs
Invalid Advance Directives Can Still Be Cogent Evidence
On June 3, 2020, the UK Court of Protection authorized the withdrawal of artificial nutrition and hydration from MSP, a 34-year-old man with severe gastrointestinal problems. Remarkable is the extent to which the court relied upon MSP's advance direct... (Source: blog.bioethics.net)
Source: blog.bioethics.net - June 5, 2020 Category: Medical Ethics Authors: Thaddeus Mason Pope, JD, PhD Tags: Health Care syndicated Source Type: blogs
Reducing your risk of changes in thinking following surgery
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery. Older adults are having more surgical procedures As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - May 22, 2020 Category: Consumer Health News Authors: Subramaniam Balachundhar, MD, MPH, FASA Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
Get your affairs in order, COVID-19 won ’t wait
The scourge of COVID-19 is spreading. Thousands of Americans are dying. What can you do to help? Yes, practice social distancing, wash your hands, and donate masks to local hospitals. Also, talk to your loved ones about advance care planning. What is advance care planning? Advance care planning means contemplating and deciding the type of medical care you would want if you had a life-threatening illness; you are never too young or too healthy to start these conversations. It involves identifying your goals and values, learning about life-sustaining interventions — such as cardiopulmonary resuscitation (measures to restar...
Source: Harvard Health Blog - April 22, 2020 Category: Consumer Health News Authors: Ashwini Bapat, MD Tags: Emergency Planning End of life Health Health care Source Type: blogs
Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at PeoplesPharmacy.com. [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon: Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs