TWiV 1007: Fragile DNA, viruses, cancer
TWiV explains genetic changes in nOPV2 strains that paralyzed children, outbreak of raccoon distemper in Toronto, EcoHealth Alliance gets its NIH grant back, and breakage at chromosomal fragile sites caused by the EBNA1 protein of Epstein-Barr virus as a mechanism for carcinogenesis. Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Register for ASV 2023 Research assistant position at FDA (pdf) MicrobeTV Discord Server nOPV2 after two years (Polioeradication) Raccoon distemperÂ...
Source: This Week in Virology - MP3 Edition - May 14, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 1001: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortalit...
Source: This Week in Virology - MP3 Edition - April 23, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 985: Bambi's revenge
TWiV reviews an outbreak of Marburg hemorrhagic fever in Equatorial Guinea, wild poliovirus type 3 shedding from a laboratory in the Netherlands, and white-tailed deer as a reservoir for previous SARS-CoV-2 variants of concern. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode •Register for ASV 2023 •MicrobeTV Discord Server •Marburg virus disease outbreak in Equatorial Guinea (WHO) •Wild-type poliovirus type 3 from laboratory (Eurosurveillance) •Extinct SARS-CoV-2 VOC in white-t...
Source: This Week in Virology - MP3 Edition - February 19, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 984: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses the political polarization of COVID-19 treatments among physicians and laypeople in the United States, seven alternatives to evidence-based medicine, Malawi’s cholera death toll crosses 1,300 in its deadliest outbreak on record, impact of coronavirus infections on pediatric patients at a tertiary pediatric hospital, maternal mRNA COVID-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants, yes masks reduce the risk of spreading infection, despite a review saying they don’t, COVID-19 and airborne transmission: science rejected,...
Source: This Week in Virology - MP3 Edition - February 18, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 957: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks, changes in population immunity against infection and severe disease from SARS-CoV-2 Omicron variants in the United States, updates on COVID-19–related mortality, impact of community masking on COVID-19, effectiveness of the COVID-19 vaccines against hospitalization with Omicron sub-lineages BA.4 and BA.5 in England, cardiovascular outcomes after Tixagevimab and Cilgavimab use for pre-exposure prophylaxis against COVID-19, how Paxlovid is associated with decreased hospit...
Source: This Week in Virology - MP3 Edition - November 26, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 950: Prion diseases with Richard Knight
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Richard Knight about prion diseases and the outbreak of bovine spongiform encephalitis that led to cases of variant Creutzfeldt-Jakob disease in humans. Host: Vincent Racaniello Guest: Richard Knight Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode National CJD Research and Surveillance Unit Clinical diagnosis of human prion disease (Prog Mol Biol Trans Sci) Variant Creutzfeldt-Jakob disease (Handbook Clin Viral) Creutzfeldt-Jakob disease (Adv Exp Med Bi...
Source: This Week in Virology - MP3 Edition - October 30, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 943: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses high points of the multi-national monkeypox outbreaks, monkeypox virus genome mutations, possible occupational infection of healthcare workers with monkeypox virus, rates of monkeypox cases by vaccination status, protection of SARS-CoV-2 infection against reinfection, Paxlovid significantly reduces COVID-19 hospitalizations and deaths, and rebound in COVID19 with and without Paxlovid treatment. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Research assistant position with Amy Rosenfeld (pdf) Support M...
Source: This Week in Virology - MP3 Edition - October 8, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 937: Pediatric hepatitis with Emma Thomson
From the European Society for Clinical Virology 2022 Conference in Manchester UK, Vincent speaks with Emma Thomson about the recent outbreak of pediatric hepatitis of unknown etiology and the finding that it is linked to infection by adenovirus-associated virus 2. Hosts: Vincent Racaniello Guest: Emma Thomson Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Thomson laboratory Emma on TWiV 188 and TWiV 341 AAV2-associated pediatric hepatitis (bioRxiv) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments ...
Source: This Week in Virology - MP3 Edition - September 18, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 932: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses vaccine effectiveness against influenza illness in children, clinical manifestations of infection with poliovirus, spike protein-independent attenuation of SARS-CoV-2 Omicron variant in laboratory mice, concordance of SARS-CoV-2 results in self-collected nasal swabs vs swabs collected by health care workers in children and adolescents, probable animal-to-human transmission of SARS-CoV-2 causing a pet shop-related outbreak, laboratory-confirmed COVID-19–associated hospitalizations among adults during BA.2 variant, SARS-CoV-2 specific T-cells and antibodies, Nirmatr...
Source: This Week in Virology - MP3 Edition - September 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Talk Evidence - a new way of understanding antidepressant effectiveness
In this week's episode, Joe Ross, professor of medicine at Yale, and The BMJ's US research editor, and Juan Franco, researcher at Heinrich-Heine-Universit ät and editor in chief of BMJ EBM are in the hot-seat.
They will discuss new research on the effectiveness of antidepressants - based on all the individual patient data submitted to the FDA between 1979 and now.
We'll take a look at a study of industry sponsorship of cost effectiveness analysis, and seeing similar patters of publication bias to RCTs.
And finally we'll be talking about new research on the ongoing, and emergent pandemics - covid and monkeypox.
Readin...
Source: The BMJ Podcast - August 24, 2022 Category: General Medicine Authors: BMJ talk medicine Source Type: podcasts
Talk Evidence - a new way of understanding antidepressant effectiveness
In this week's episode, Joe Ross, professor of medicine at Yale, and The BMJ's US research editor, and Juan Franco, researcher at Heinrich-Heine-Universität and editor in chief of BMJ EBM are in the hot-seat.
They will discuss new research on the effectiveness of antidepressants - based on all the individual patient data submitted to the FDA between 1979 and now.
We'll take a look at a study of industry sponsorship of cost effectiveness analysis, and seeing similar patters of publication bias to RCTs.
And finally we'll be talking about new research on the ongoing, and emergent pandemics - covid and monkeypox.
Reading...
Source: The BMJ Podcast - August 24, 2022 Category: General Medicine Authors: BMJ Group Source Type: podcasts
TWiV 927: Merchlinsky vs monkeypox
Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler Guest: Michael Merchlinsky Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Michael on Anything but academic (TWiM 145) Development of Tecoviromat (TPOXX) (Antiviral Res) Use of Jynneos vaccine (MMWR) Limitations of Tecoviromat (NEJM) Poliovirus in NYC wastewater (NY Times) Letters read on TWiV 927 Timestamps by Jolene...
Source: This Week in Virology - MP3 Edition - August 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 918: COVID-19 clinical update #123 with Dr. Daniel Griffin
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sampling to improve access to diagnosis in low-resource settings, oral sabizabulin for high-risk hospitalized adults, lower-risk of m...
Source: This Week in Virology - MP3 Edition - July 16, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Diagnosis, Prevention, and Treatment of Monkeypox
JAMA Associate Editor Preeti Malani, MD, MSJ, discusses the transmission, diagnosis, and treatment of monkeypox and the 2022 outbreak with Jeannette Guarner, MD, and Carlos del Rio, MD, both of the Division of Infectious Diseases at Emory University’s School of Medicine. Related Content: Monkeypox in 2022—What Clinicians Need to Know What Is Monkeypox? What to Know About Monkeypox Global Monkeypox Outbreaks Spur Drug Research for the Neglected Disease (Source: JAMA Author Interviews)
Source: JAMA Author Interviews - July 15, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
TWiV 915: Mouse mouth to mouse mom
TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory (pdf) COVID vaccine update for fall (WaPo) Don’t rush to change COVID vaccines (STAT) Materials from 28 June FDA advisory meeting (FD...
Source: This Week in Virology - MP3 Edition - July 3, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
