Osteogenesis Imperfecta (brittle bone disease) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adult human cardiomyocyte mechanics in osteogenesis imperfecta
Am J Physiol Heart Circ Physiol. 2023 Aug 11. doi: 10.1152/ajpheart.00391.2023. Online ahead of print.ABSTRACTOsteogenesis imperfecta (OI) is an extracellular matrix disorder characterized by defects in collagen 1 transport or synthesis, resulting in bone abnormalities. While reduced collagen in OI hearts have been associated with reduced myocardial stiffness and left ventricular remodeling, its impact upon cardiomyocyte (CM) function have not been studied. Here we explore the tissue-level and CM-level properties of a heart from a deceased organ donor with OI Type I. Proteomics and histology confirmed strikingly low expres...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 11, 2023 Category: Physiology Authors: Benjamin W Lee Matthew A Caporizzo Christina Y Chen Kenneth C Bedi Eliot G Peyster Benjamin L Prosser Kenneth B Margulies Alexia Vite Source Type: research

Correction to: How does alendronate affect orthodontic tooth movement in osteogenesis imperfecta: an in vivo study on a mice model
Eur J Orthod. 2023 Aug 8:cjad048. doi: 10.1093/ejo/cjad048. Online ahead of print.NO ABSTRACTPMID:37552030 | DOI:10.1093/ejo/cjad048 (Source: European Journal of Orthodontics)
Source: European Journal of Orthodontics - August 8, 2023 Category: Dentistry Source Type: research

Morphological variability in the inner ear of mice with osteogenesis imperfecta
In this study, we examine OI-related pathologies of the cochlea in a mouse model of OI to (1) document variation between OI and unaffected mice, and (2) assess the intrusion of the otic capsule onto the cochlea by analyzing differences in duct volumes. Juvenile and adult OIM C57BL/6mice were compared to unaffected wildtype (WT) mice using three-dimensional models of the cochlea generated from high resolution micro-CT scans. Two-tailed Mann-Whitney U tests were then used to investigate duct volume differences both within and between the OI and WT samples. Areas of higher ossification were observed at the cochlear base in th...
Source: Anatomical Record - July 29, 2023 Category: Anatomy Authors: Lila A Huston Tooba S Husain Jacob C Moore Jason M Organ Rachel A Menegaz Emma K Handler Lauren A Gonzales Source Type: research

Descemetocele in osteogenesis imperfecta: Case report
J Fr Ophtalmol. 2023 Jul 26:S0181-5512(23)00293-0. doi: 10.1016/j.jfo.2023.02.011. Online ahead of print.NO ABSTRACTPMID:37507291 | DOI:10.1016/j.jfo.2023.02.011 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - July 28, 2023 Category: Opthalmology Authors: H Taouti S Belghmaidi I Hajji A Moutaouakil Source Type: research