Noonan syndrome: rhGH treatment and PTPN11 mutation
CONCLUSION: Noonan syndrome is characterized by slow growth, short stature, mental retardation, peculiar facial features, structural heart abnormalities and abnormal bone metabolism. and osteochondroma was found after case 2 rhGH treatment. Genetic examination is mostly caused by PTPN11 mutation. It is recommended to pay attention to bone metabolism abnormalities before growth hormone treatment, especially in children with PTPN11 mutations.PMID:37525886 | DOI:10.1002/mgg3.2266 (Source: Molecular Medicine)
Source: Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Xian Wu Jiali Wu Yi Yuan Li Yang Lirong Yu Source Type: research
Noonan syndrome: rhGH treatment and PTPN11 mutation
CONCLUSION: Noonan syndrome is characterized by slow growth, short stature, mental retardation, peculiar facial features, structural heart abnormalities and abnormal bone metabolism. and osteochondroma was found after case 2 rhGH treatment. Genetic examination is mostly caused by PTPN11 mutation. It is recommended to pay attention to bone metabolism abnormalities before growth hormone treatment, especially in children with PTPN11 mutations.PMID:37525886 | DOI:10.1002/mgg3.2266 (Source: Molecular Medicine)
Source: Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Xian Wu Jiali Wu Yi Yuan Li Yang Lirong Yu Source Type: research
Noonan syndrome: rhGH treatment and PTPN11 mutation
ConclusionNoonan syndrome is characterized by slow growth, short stature, mental retardation, peculiar facial features, structural heart abnormalities and abnormal bone metabolism. and osteochondroma was found after case 2 rhGH treatment. Genetic examination is mostly caused byPTPN11 mutation. It is recommended to pay attention to bone metabolism abnormalities before growth hormone treatment, especially in children withPTPN11 mutations. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - August 1, 2023 Category: Genetics & Stem Cells Authors: Xian Wu,
Jiali Wu,
Yi Yuan,
Li Yang,
Lirong Yu Tags: CLINICAL REPORT Source Type: research
Metacarpal Neck Osteochondroma: An Atypical Cause of "Trigger Finger"
J Hand Surg Glob Online. 2023 Apr 18;5(4):463-466. doi: 10.1016/j.jhsg.2023.03.010. eCollection 2023 Jul.ABSTRACT"Locking" of the digits is a relatively common patient complaint in hand surgery. Typically, this phenomenon arises from either triggering of tendons at the A1 pulley or subluxation of tendons around the metacarpal head. Although trigger digit and sagittal band injury comprise most diagnoses, clinicians must be aware of rarer entities that alter the underlying osseous anatomy and predispose the digits to "locking." Here, we present a case of metacarpal neck osteochondroma causing subluxation of the index metacar...
Source: Hand Surgery - July 31, 2023 Category: Surgery Authors: Jonathan Layne Maximilian A Meyer Louis W Catalano Source Type: research
Metacarpal Neck Osteochondroma: An Atypical Cause of "Trigger Finger"
J Hand Surg Glob Online. 2023 Apr 18;5(4):463-466. doi: 10.1016/j.jhsg.2023.03.010. eCollection 2023 Jul.ABSTRACT"Locking" of the digits is a relatively common patient complaint in hand surgery. Typically, this phenomenon arises from either triggering of tendons at the A1 pulley or subluxation of tendons around the metacarpal head. Although trigger digit and sagittal band injury comprise most diagnoses, clinicians must be aware of rarer entities that alter the underlying osseous anatomy and predispose the digits to "locking." Here, we present a case of metacarpal neck osteochondroma causing subluxation of the index metacar...
Source: Hand Surgery - July 31, 2023 Category: Surgery Authors: Jonathan Layne Maximilian A Meyer Louis W Catalano Source Type: research
Rare retro ‐patellar multiple osteochondromas in patellar tendon: A case report
x-Ray image of the left knee joint. Multiple OC within the patellar tendon. Bone wear (asterisk) is evident at the femoral condyle and tendon attachment to the tibial tuberosity. F, femur; Fi, fibula; OC, OC masses; P, patella; PL, patellar ligament; T, tibia; TT, tibial tuberosity. Key Clinical MessageOsteochondromas (OCs) are developmental anomalies that originate from the periosteum and typically form during enchondral ossification near the joints. Retro-patellar OC caused by exostosis forms in various intracapsular, intra-tendon, and joint-adjacent positions within the knee joint. In this case, a 19-year-old male prese...
Source: Clinical Case Reports - July 31, 2023 Category: General Medicine Authors: Hosein Pirmohamadi,
Mohsen Rahimi,
Mohammad Kazem Emami Meibodi,
Mohsen Akbaribazm Tags: CASE REPORT Source Type: research
Hip joint osteochondroma treated with short stem total hip arthroplasty: a case report
Acta Biomed. 2023 Jul 24;94(S1):e2023188. doi: 10.23750/abm.v94iS1.14671.ABSTRACTThe purpose of this report is to present the clinical and radiological findings of a young patient affected by proximal femoral and acetabular osteochondroma. This benign primary tumor of the long bones occurs in childhood and is localized in the proximal femur only with low incidence. As far as we know, there are only 30 other cases in the literature of an osteochondroma involving the entire hip joint. Out of these 30, only 17 patients were treated with lesion excision and joint replacement. However this is the first patient treated with a sh...
Source: Acta Bio-Medica : Atenei Parmensis - July 24, 2023 Category: General Medicine Authors: Francesco Calafiore Andrea Fidanza Michele Venosa Riccardo Fabiani Giandomenico Logroscino Source Type: research
Hip joint osteochondroma treated with short stem total hip arthroplasty: a case report
Acta Biomed. 2023 Jul 24;94(S1):e2023188. doi: 10.23750/abm.v94iS1.14671.ABSTRACTThe purpose of this report is to present the clinical and radiological findings of a young patient affected by proximal femoral and acetabular osteochondroma. This benign primary tumor of the long bones occurs in childhood and is localized in the proximal femur only with low incidence. As far as we know, there are only 30 other cases in the literature of an osteochondroma involving the entire hip joint. Out of these 30, only 17 patients were treated with lesion excision and joint replacement. However this is the first patient treated with a sh...
Source: Acta Bio-Medica : Atenei Parmensis - July 24, 2023 Category: General Medicine Authors: Francesco Calafiore Andrea Fidanza Michele Venosa Riccardo Fabiani Giandomenico Logroscino Source Type: research
Benign Brain and Spinal Tumors Originating from Bone or Cartilage
Adv Exp Med Biol. 2023;1405:457-476. doi: 10.1007/978-3-031-23705-8_17.ABSTRACTBenign osseocartilaginous tumors of the spine are overall uncommon, representing between 1 and 13% of all primary bone tumors and less than 10% of all spinal tumors. Tumors in this category include osteoblastic lesions such as the related osteoid osteoma and osteoblastoma, and cartilage-forming lesions including osteochondroma, chondroma, and chondroblastoma. Aneurysmal bone cysts, giant cell tumors of bone, and eosinophilic granulomas also comprise benign tumors of the spine arising from bone. There is significant heterogeneity in the epidemiol...
Source: Advances in Experimental Medicine and Biology - July 15, 2023 Category: Research Authors: Abhishek Gami Andrew Schilling Jeff Ehresman Daniel M Sciubba Source Type: research
