BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Optional)
Funding Opportunity RFA-DA-24-042 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) seeks applications proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate, and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organisms social or physical environment; and 2) develop data science and computational methods that allow for integ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 28, 2023 Category: Research Source Type: funding

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Funding Opportunity RFA-NS-24-029 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) and the Office of the Director, National Institutes of Health (OD), intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for the conduct of scientific research utilizing data from expanded access (EA) to investigational drugs or biological products. These applications will target intermediate size populations of patients living with amyotrophic lateral sclerosis (ALS) who are not otherwise eligible for clinical tria...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 21, 2023 Category: Research Source Type: funding

Notice of Special Interest (NOSI): Administrative Supplements to Support Addiction Science and Related Neuroscience Pilot Research Projects at NIMHD-Funded Research Centers in Minority Institutions (RCMI)
Notice NOT-MD-23-019 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 15, 2023 Category: Research Source Type: funding

What Early Career Researchers Should Know (Part 2) – Discovering Strengths to Advance Your Research Career
Ericka Boone, PhD, Director, Division of Biomedical Research Workforce, NIH Marguerite Matthews, PhD, Program Director and co-host of Building Up the Nerve, NINDS In our second episode of a two-part NIH All About Grants mini-series, we explore ways early career researchers can align and apply their strengths to advance their professional development. Dr. Marguerite Matthews, a program director and co-host of Building Up the Nerve with the National Institute of Neurological Disorders and Stroke, and Dr. Ericka Boone, Director of the Division of Biomedical Research Workforce at the NIH Office of Extramural Research, joi...
Source: NIH Extramural Nexus - November 6, 2023 Category: Research Authors: NIH Staff Tags: New Resources biomedical research workforce podcast postdocs Source Type: funding

Targeting Inflammasomes in HIV and Substance Use (R21 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-25-013 from the NIH Guide for Grants and Contracts. The scientific objective of this Funding Opportunity Announcement is to encourage research to delineate the role of inflammasomes in the neuropathology produced by acute or chronic drug exposure and HIV infection. Understanding the involvement of inflammasomes in virus and drug-induced immune activation may help identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among substance abuse populations, as well as identify novel therapies to target inflammasome activation or suppression to treat ne...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 17, 2023 Category: Research Source Type: funding

Targeting Inflammasomes in HIV and Substance Use (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-25-012 from the NIH Guide for Grants and Contracts. The scientific objective of this Notice of Funding Opportunity is to encourage research to delineate the role of inflammasomes in the neuropathology produced by acute or chronic drug exposure and HIV infection. Understanding the involvement of inflammasomes in virus and drug-induced immune activation may help identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among substance abuse populations, as well as identify novel therapies to target inflammasome activation or suppression to treat neuro...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 17, 2023 Category: Research Source Type: funding

Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R01 Basic Experimental Studies with Humans Required)
Funding Opportunity RFA-DA-24-032 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to encourage clinical research that will identify and validate novel targets for non-invasive brain stimulation (NIBS) and SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that precede clinical outcomes like reduced craving or drug use. This NOFO uses an R01 activity code to support applications that propose mechanistic studies designed to understand a behavior or biological process, the pathophysiology of a disease, or the mechanism of action of an intervent...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 29, 2023 Category: Research Source Type: funding

Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R01 Clinical Trial Optional)
Funding Opportunity RFA-DA-24-031 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to encourage clinical research that will identify and validate novel targets for non-invasive brain stimulation (NIBS) and SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that precede clinical outcomes like reduced craving or drug use. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP), which will be assessed as part of the scientific and technical peer review evaluation. Applications that fail to include a PEDP will be considered incomplete...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 28, 2023 Category: Research Source Type: funding

Mechanistic Studies of the Effects of Psychosocial Stress on Complex Morbidity Involving SUD, Psychiatric Disorders, and HIV (R01 Basic Experimental Studies with Humans (BESH) Required)
Funding Opportunity RFA-DA-24-006 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to solicit proposals for basic science experiments involving humans (BESH) aimed at elucidating neurobiological mechanisms underlying the influence of psychosocial stress on neurobehavioral function and risk for substance use disorders (SUD) and co-occurring psychiatric disorders in people living with HIV (PLWH). As referred to in NOT-OD-18-212, BESH are prospective basic science studies involving human participants that fall within the NIH definition of a clinical trial and also mee...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 26, 2023 Category: Research Source Type: funding

BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
Funding Opportunity RFA-EY-23-001 from the NIH Guide for Grants and Contracts. This FOA seeks applications for unique and innovative recording and/or modulation technologies that are in the earliest stage of development, including new and untested ideas that are in the initial stages of conceptualization. Some projects may aim to increase recording or modulation capabilities by many orders of magnitude, while others may aim to improve the precision and selectivity of recording or modulation (also referred to as stimulation, perturbation, or manipulation). A wide range of modalities are appropriate including acoustic, ch...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2023 Category: Research Source Type: funding

NIH All About Grants Podcast: What Early Career Researchers Should Know (Part 1) – the Hidden Curriculum
Dr. Lauren Ullrich, co-host of Building Up the Nerve from the National Institute of Neurological Disorders and Stroke Dr. Oliver Bogler, host of Inside Cancer Careers from the National Cancer Institute Embarking on a career in biomedicine is more than doing experiments and writing NIH grant applications. How does one learn about other important skills early in their research career, and what exactly are they? This episode of a two-part NIH All About Grants Podcast mini-series explores the “hidden curriculum” for early career researchers. Our conversation features hosts of two NIH podcasts that delve into topics ...
Source: NIH Extramural Nexus - September 8, 2023 Category: Research Authors: NIH Staff Tags: New Resources mentorship podcast workforce Source Type: funding

BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R01 Clinical Trial Optional)
Funding Opportunity RFA-MH-24-190 from the NIH Guide for Grants and Contracts. Reissue of RFA-MH-21-205 to comply with DMS Policy. This Notice of Funding Opportunity (NOFO), in support of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, is one of several NOFOs aimed at supporting transformative discoveries that will lead to breakthroughs in understanding human brain function. Guided by the long-term scientific plan, BRAIN 2025: A Scientific Vision, this NOFO specifically seeks to support efforts addressing core ethical issues associated with research focused on the human brain an...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 1, 2023 Category: Research Source Type: funding

NIH All About Grants Podcast: Reporting on Your Scientific Progress
Tom Cheever, Program Officer, National Institute of Neurological Disorders and Stroke, NIH As part of proper stewardship and transparency, recipients must periodically tell NIH about their research progress outcomes and accomplishments when receiving an award (see NIH Grants Policy Statement Section 8.4.1 for policy and regulatory references). What exactly should someone report on and when though? Dr. Tom Cheever, a program officer with the National Institute of Neurological Disorders and Stroke, explains more about progress reporting in this episode of the NIH All About Grants podcast. Join us as we discuss what the ...
Source: NIH Extramural Nexus - August 18, 2023 Category: Research Authors: NIH Staff Tags: New Resources Grants policy podcast RPPR Source Type: funding

Addressing Rigor in Scientific Studies
Guest blog by Devon C. Crawford, Ph.D., Program Director, Office of Research Quality, NIH’s National Institute of Neurological Disorders and Stroke. Originally published on the NIH Science, Health, and Public Trust blog. Devon C. Crawford, Ph.D., Program Director, Office of Research Quality Science communication is rapidly evolving. The growing use of preprints and the sheer number of published studies make it increasingly difficult to determine which findings are worthy of attention. Not all scientific studies are created equal. Communicators need to discern which are reputable in order to know what to co...
Source: NIH Extramural Nexus - August 14, 2023 Category: Research Authors: NIH Staff Tags: blog Open Mike Grants policy rigor Source Type: funding

Neural and Non-Neural Mechanisms Underlying Gait as a Preclinical Marker for Alzheimers Disease and Alzheimers Disease-Related Dementias (R01 Clinical Trial Optional)
Funding Opportunity RFA-AG-24-041 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to invite applications that investigate the neural and/or non-neural mechanisms that underlie the association between gait and cognition in aging and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). Elucidating these mechanisms would help inform the potential use of changes gait as an early biomarker of AD/ADRD or inform the design of early interventions for AD/ADRD. To achieve these goals, it will be necessary to facilitate a team science approach by bringing...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding