Take Advantage of Our Many Resources for Enhancing the Rigor of Animal Research
“Despite the numerous successes stemming from animal research, concerning reports over the past decade have described biomedical experiments that fail to replicate or to translate in ways that improve human health. All research is not expected to translate to human treatments, as there is no perfect model. Scientific process is as much about failure as it is about success. Yet part of the scientific process is also continual improvement, which includes working to understand what might contribute to unexpected outcomes within animal research.”
The Advisory Committee to the NIH Director (ACD) expressed that view in their...
Source: NIH Extramural Nexus - February 10, 2023 Category: Research Authors: Mike Lauer Tags: blog Open Mike Alternatives to Animals reproducibility rigor Source Type: funding
Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional)
Funding Opportunity RFA-DA-24-037 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing the innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of drug using behaviors (defined as alcohol, tobacco, prescription and other drug) and related disorders, prevention of drug use and HIV, and health service utilization. This FOA encourages the analyses of public use and other extant community-based or clinical datasets to their full potential in order to incre...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 7, 2023 Category: Research Source Type: funding
Data Harmonization, Curation and Secondary Analysis of Existing Clinical Datasets (R61/R33 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-089 from the NIH Guide for Grants and Contracts. This FOA invites applications from multidisciplinary teams to perform secondary data analysis, using existing datasets from two or more multi-site clinical research projects, to address scientific and clinical hypotheses relevant to neurological disorders and conditions within the NINDS mission. In this phased funding mechanism, applications are required to systematically and comprehensively perform cross-project data harmonization and curation, assessed using Go/No-go data-quality metrics, prior to funding of the second phase of data analyses. ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 31, 2023 Category: Research Source Type: funding
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)
Funding Opportunity RFA-NS-23-012 from the NIH Guide for Grants and Contracts. The National Institute of Neurological Disorders and Stroke (NINDS) and the Office of the Director, National Institutes of Health (OD), intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to solicit applications for the conduct of scientific research utilizing data from expanded access (EA) to investigational drugs or biological products. These applications will target intermediate size populations of patients living with amyotrophic lateral sclerosis (ALS) who are not otherwise eligible for clinical tria...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 9, 2023 Category: Research Source Type: funding
Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-091 from the NIH Guide for Grants and Contracts. The overall goal of this Funding Opportunity Announcement (FOA) is to identify, in animals, in vivo neurophysiological and behavioral measures for use as assays in the early screening phase of treatment development. The FOA will support efforts to optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. The screening assays thus developed from this FOA are expected to build upon s...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 6, 2023 Category: Research Source Type: funding
Notice of Special Interest (NOSI): Administrative Supplements to Support Addiction Science and Related Neuroscience Pilot Research Projects at NIMHD-Funded Research Centers in Minority Institutions (RCMI)
Notice NOT-MD-23-001 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 20, 2022 Category: Research Source Type: funding
NIH StrokeNet- Regional Coordinating Stroke Centers for year 2023 (U24 - Clinical Trials Not Allowed)
Funding Opportunity RFA-NS-23-010 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite currently awarded NIH StrokeNet centers and potential new stroke centers to participate as a Regional Coordinating Stroke Center (RCC) in the NIH StrokeNet clinical trials network. Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions fo...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 15, 2022 Category: Research Source Type: funding
NIH StrokeNet National Coordinating Center for year 2023 (U01 Clinical Trials Not Allowed)
Funding Opportunity RFA-NS-23-009 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as the National Coordinating (NCC) Center for the NIH Stroke Trials Network.Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 15, 2022 Category: Research Source Type: funding
NIH StrokeNet National Data Management Center for year 2023 (U01 Clinical Trials Not Allowed)
Funding Opportunity RFA-NS-23-008 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as the National Data Management Center (NDMC) for the NIH Stroke Trials Network. Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portf...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 15, 2022 Category: Research Source Type: funding
Targeting Inflammasomes in Substance Abuse and HIV (R21 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-24-004 from the NIH Guide for Grants and Contracts. The scientific objective of this Funding Opportunity Announcement is to encourage research to delineate the role of inflammasomes in the neuropathology produced by acute or chronic drug exposure and HIV infection. Understanding the involvement of inflammasomes in virus and drug-induced immune activation may help identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among substance abuse populations, as well as identify novel therapies to target inflammasome activation or suppression to treat ne...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 3, 2022 Category: Research Source Type: funding
Targeting Inflammasomes in Substance Abuse and HIV (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-24-003 from the NIH Guide for Grants and Contracts. The scientific objective of this Funding Opportunity Announcement is to encourage research to delineate the role of inflammasomes in the neuropathology produced by acute or chronic drug exposure and HIV infection. Understanding the involvement of inflammasomes in virus and drug-induced immune activation may help identify molecular markers and CNS immune cells associated with HIV-1 infection or disease progression among substance abuse populations, as well as identify novel therapies to target inflammasome activation or suppression to treat ne...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 3, 2022 Category: Research Source Type: funding
Functional Validation and/or Characterization of Genes or Variants Implicated in Substance Use Disorders (R21/R33 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-041 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support projects which exploit genome or epigenome editing to functionally validate and characterize genes or variants involved in substance use disorder-relevant phenotypes. It is expected that any genetic resources generated will be made broadly available to the scientific community to enable investigation of the relevant neurobiological mechanisms involved and provide critical foundational knowledge for the development of future prevention, diagnostic, and therapeutic strategies. (Source: NIH Funding Oppor...
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 1, 2022 Category: Research Source Type: funding
Collaborative Research in Computational Neuroscience (CRCNS)
Full Proposal Deadline Date: November 22, 2022 Deadline for FY 2023 competition Program Guidelines: NSF 20-609Computational neuroscience provides a theoretical foundation and a rich set of technical approaches for understanding complex neurobiological systems, building on the theory, methods, and findings of computer science, neuroscience, and numerous other disciplines.
Through the CRCNS program, the U.S. National Science Foundation (NSF), National Institutes of Health (NIH), and Department of Energy (DOE); the German Federal Ministry of Education and Research (Bundesministerium für ...More at https://beta.nsf.gov/p...
Source: NSF Upcoming Due Dates - October 23, 2022 Category: Science Source Type: funding
BRAIN Initiative: Brain-Behavior Quantification and Synchronization Transformative and Integrative Models of Behavior at the Organismal Level (R34 Clinical Trial Not Allowed)
Funding Opportunity RFA-DA-23-030 from the NIH Guide for Grants and Contracts. This R34 Funding Opportunity Announcement (FOA) seeks applications with limited scope proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organisms social or physical environment; and/or 2) develop computational methods that allow...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 11, 2022 Category: Research Source Type: funding
Limited Competition: Environmental influences on Child Health Outcomes (ECHO) Cohort Study Sites for Pediatric Follow Up. Clinical Trial Not Allowed (UG3/UH3)
The objectives of this FOA are to solicit applications to 1) lead collaborative ECHO Cohort science, 2) follow up existing ECHO Cohort participants, and 3) implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortiums central data capture system, e.g., REDCap Central. This FOA does not support site-specific analyses and science. Only current ECHO Cohort awardees are eligible to apply. This new funding period will be 7 years in duration provided successful performance in the UG3 phase and the UH3 phase. This FOA runs in parallel with companion FOAs that solicit applications for Cohort...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 30, 2022 Category: Research Source Type: funding
