Perioperative Nivolumab Improves EFS in Resectable NSCLC Perioperative Nivolumab Improves EFS in Resectable NSCLC
Interim findings from CheckMate 77T show an overall improvement in event-free survival with perioperative nivolumab vs neoadjuvant nivolumab plus chemotherapy only.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - October 21, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Can Some Patients With Esophageal Cancer Avoid Surgery? Can Some Patients With Esophageal Cancer Avoid Surgery?
About one third of patients with esophageal cancer who have a compete response to neoadjuvant chemoradiotherapy may be able to avoid surgery. However, one expert questioned the study design.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - October 20, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

FDA approves neoadjuvant/ adjuvant pembrolizumab for resectable non-small cell lung cancer
On October 16, 2023, the Food and Drug Administration approved pembrolizumab (Keytruda, Merck) with platinum-containing chemotherapy as neoadjuvant treatment, and with continuation of single-agent pembrolizumab as post-surgical adjuvant treatment for resectable (tumors ≥4 cm or node positive) non-sm (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - October 16, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news

FDA Approves Keytruda (pembrolizumab) for Treatment of Patients With Resectable NSCLC in Combination With Chemotherapy as Neoadjuvant Treatment, Then Single Agent as Adjuvant Treatment After Surgery
RAHWAY, N.J.--(BUSINESS WIRE) October 16, 2023 -- Merck (NYSE: MRK), known as MSD outside of the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Keytruda , Merck’s anti-PD-1 therapy, for... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - October 16, 2023 Category: Drugs & Pharmacology Source Type: news

Bladder-Sparing Neoadjuvant Protocol Gets High Marks for MIBC
(MedPage Today) -- More than 40% of patients with muscle-invasive bladder cancer (MIBC) avoided immediate cystectomy after achieving a clinical complete response (cCR) with a chemoimmunotherapy combination, a prospective study showed. Overall... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - October 6, 2023 Category: Hematology Source Type: news

Delaying Esophageal Cancer Surgery After Neoadjuvant CRT Fails in Trial
(MedPage Today) -- Prolonging the time to surgery following neoadjuvant chemoradiotherapy (CRT) for esophageal cancer failed to improve histological complete response rates and may even worsen overall survival (OS), according to results from the... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - September 19, 2023 Category: Gastroenterology Source Type: news

Surgical Outcomes of Perioperative Durvalumab in AEGEAN Study to be Presented at IASLC 2023 World Conference on Lung Cancer
Adding perioperative durvalumab to neoadjuvant chemotherapy did not adversely impact surgery in patients with resectable NSCLC and was associated with a tolerable surgical safety profile, according to research presented today from the phase 3 AEGEAN trial at the International Association... (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - September 12, 2023 Category: Pharmaceuticals Tags: TRI TDS Source Type: news

Routine Thromboprophylaxis for Advanced Ovarian Cancer? Routine Thromboprophylaxis for Advanced Ovarian Cancer?
Two thirds of venous thromboembolism events came during neoadjuvant chemotherapy and might have been prevented with direct-acting oral anticoagulants, a new study suggests.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 24, 2023 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Sentinel Lymph Node Biopsy After Breast Cancer Chemotherapy Sentinel Lymph Node Biopsy After Breast Cancer Chemotherapy
This article reviews current evidence for the use of sentinel lymph node biopsy in breast cancer patients who received neoadjuvant chemotherapy.Chinese Clinical Oncology (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - July 17, 2023 Category: Radiology Tags: Hematology-Oncology Journal Article Source Type: news

Risk-Adapted Neoadjuvant Chemoradiotherapy in Rectal Cancer? Risk-Adapted Neoadjuvant Chemoradiotherapy in Rectal Cancer?
Neoadjuvant chemoradiotherapy can be omitted in low-risk rectal cancer patients without compromising outcomes, but intensified in high-risk patients, new findings suggest.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 27, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Deep-learning CT model helps predict ovarian cancer treatment response
A deep-learning model using CT images can predict neoadjuvant chemotherapy respons...Read more on AuntMinnie.comRelated Reading: Radiomic features on CT help classify ovarian cancer subtypes MRI has upper hand on CT for ovarian cancer detection Body composition foretells ovarian cancer treatment complications CT/ultrasound fusion enhances ovarian biopsies Cinematic rendering enhances pelvic CT bone evaluation (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 26, 2023 Category: Radiology Source Type: news

ASCO: FOLFOX Noninferior to Chemoradiotherapy for Overall Survival in Rectal Cancer
FRIDAY, June 9, 2023 -- Neoadjuvant chemotherapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is noninferior to preoperative chemoradiotherapy with respect to overall survival for patients with locally advanced rectal cancer who are... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 9, 2023 Category: Pharmaceuticals Source Type: news

Omitting RT Safe in Many Locally Advanced Rectal Cancers
(MedPage Today) -- CHICAGO -- Standard pelvic chemoradiotherapy prior to surgery can be safely omitted in select patients with locally advanced rectal cancer whose tumors respond to neoadjuvant chemotherapy, findings from a large cooperative... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - June 5, 2023 Category: Gastroenterology Source Type: news

Neoadjuvant Chemo Flops Versus Upfront Surgery for Resectable Pancreatic Cancer
(MedPage Today) -- CHICAGO -- Neoadjuvant chemotherapy failed to match upfront surgery for survival in resectable pancreatic cancer, a small randomized trial showed. Unexpectedly, patients assigned to surgery first lived more than a year longer... (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - June 4, 2023 Category: Surgery Source Type: news

Janssen to Highlight Scientific Advances and Commitment to Transform Cancer Care at ASCO and EHA with More than 90 Presentations Showcasing Robust, Differentiated Portfolio and Pipeline in Hematologic Malignancies and Solid Tumors
This study evaluates an investigational combination regimen of IMBRUVICA® (ibrutinib) plus venetoclax (I+V) for newly diagnosed chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL), (Abstracts #7535 and #P617, respectively).Advancing the Science of Solid Tumors Through Precision MedicineJanssen’s continued innovation in solid tumors focuses on advancing precision medicine options for patients with biomarker-driven disease who have limited targeted treatment options and moving patients into earlier lines of therapy when treatments may be more effective. Lung CancerAn oral presentation will report ...
Source: Johnson and Johnson - May 18, 2023 Category: Pharmaceuticals Tags: Innovation Source Type: news