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EBNA1 Inhibitors Block Proliferation of Spontaneous Lymphoblastoid Cell Lines From Patients With Multiple Sclerosis and Healthy Controls
This study shows that patient-derived SLCLs provide a useful tool for interrogating the role of EBV+ B cells in MS and suggests that a clinical trial testing the effect of EBNA1 inhibitors in MS may be warranted. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - August 10, 2023 Category: Neurology Authors: Monaco, M. C. G., Soldan, S. S., Su, C., Clauze, A., Cooper, J. F., Patel, R. J., Lu, F., Hughes, R. J., Messick, T. E., Andrada, F. C., Ohayon, J., Lieberman, P. M., Jacobson, S. Tags: Autoimmune diseases, Viral infections, Multiple sclerosis Research Article Source Type: research

Role of Advanced Hemodynamic Ultrasound Evaluation in the Differential Diagnosis of Middle Cerebral Artery Stenosis: Introducing Morphological Criteria
The aim of the work described here was to determine the possible impact of the new technique advanced hemodynamic ultrasound evaluation (AHUSE) in identification of severe intracranial stenosis. Transcranial Doppler (TCD) and transcranial color-coded Doppler (TCCD) provide reliable velocimetric data, the indirect analysis of which allows us to obtain information on the patency of vessels and assumed stenosis range. However, very tight stenoses (>95%) cannot be detected with velocimetric criteria because of spectrum drops and the absence of high velocities, so that the right curve of the Spencer equation cannot be solved. (...
Source: Ultrasound in Medicine and Biology - August 5, 2023 Category: Radiology Authors: Giovanni Malferrari, Nicola Merli, Vincenzo Inchingolo, Antonio Siniscalchi, Domenico Laterza, Daniela Monaco, Giorgia Arnone, Andrea Zini, Francesco Prada, Cristiano Azzini, Maura Pugliatti Tags: Technical Note Source Type: research

Real life use of prostacyclin analog (iloprost), a multi-centric survey data from the Scleroderma study group Emilia Romagna (Sclero-RER) and review of the literature
CONCLUSIONS: These observations were in line with the majority of previous studies reporting different regimens, comparing similar (but not identical) dose and schedule administration, however, despite differences being at times substantial, no standard infusion method is yet available.PMID:37539603 | DOI:10.23750/abm.v94i4.14317 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Luca Magnani Alarico Ariani Andrea Lo Monaco Francesco Girelli Amelia Spinella Federica Lumetti Massimo Reta Eugenio Arrigoni Francesco Ursini Alessandra Bezzi Pierluigi Cataleta Luca Montaguti Marica Trevisani Matteo Colina Simone Bernardi Marco De Pinto Source Type: research