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Correlations between the degree of infection by wild strain of Toxoplasma gondii in vitro and porcine hematological parameters
Exp Parasitol. 2024 Apr 16:108754. doi: 10.1016/j.exppara.2024.108754. Online ahead of print.ABSTRACTThe apicomplexa Toxoplasma gondii is capable of actively proliferating in numerous types of nucleated cells, and therefore has a high potential for dissemination and resistance. Thus, the present work aimed to correlate the inoculum concentrations and amount of post-infection parasites with porcine hematological parameters (including biochemistry) through in vitro culture. Porcine blood was incubated with different concentrations of parasites (1.2 x 107, 6 / 3 / 1.5 x 106 cells/mL), then the concentrations of red blood cell...
Source: Experimental Parasitology - April 18, 2024 Category: Parasitology Authors: Carlos Vinicius Barros Oliveira Maria Elenilda Paulino da Silva Jailson Renato de Lima Amanda Maria Tavares Moreira Maria J éssica Mendes Brito Cicera Alane Coelho Gon çalves Jo ão Eudes Lemos de Barros Rom ário Matheus de Oliveira Jean Paul Kamdem Lu Source Type: research

Correlations between the degree of infection by wild strain of Toxoplasma gondii in vitro and porcine hematological parameters
Exp Parasitol. 2024 Apr 16;261:108754. doi: 10.1016/j.exppara.2024.108754. Online ahead of print.ABSTRACTThe apicomplexa Toxoplasma gondii is capable of actively proliferating in numerous types of nucleated cells, and therefore has a high potential for dissemination and resistance. Thus, the present work aimed to correlate the inoculum concentrations and amount of post-infection parasites with porcine hematological parameters (including biochemistry) through in vitro culture. Porcine blood was incubated with different concentrations of parasites (1.2 × 107, 6/3/1.5 × 106 cells/mL), then the concentrations of red blood ce...
Source: Experimental Parasitology - April 18, 2024 Category: Parasitology Authors: Carlos Vinicius Barros Oliveira Maria Elenilda Paulino da Silva Jailson Renato de Lima Amanda Maria Tavares Moreira Maria J éssica Mendes Brito Cicera Alane Coelho Gon çalves Jo ão Eudes Lemos de Barros Rom ário Matheus de Oliveira Jean Paul Kamdem Lu Source Type: research

Correlations between the degree of infection by wild strain of Toxoplasma gondii in vitro and porcine hematological parameters
Exp Parasitol. 2024 Apr 16;261:108754. doi: 10.1016/j.exppara.2024.108754. Online ahead of print.ABSTRACTThe apicomplexa Toxoplasma gondii is capable of actively proliferating in numerous types of nucleated cells, and therefore has a high potential for dissemination and resistance. Thus, the present work aimed to correlate the inoculum concentrations and amount of post-infection parasites with porcine hematological parameters (including biochemistry) through in vitro culture. Porcine blood was incubated with different concentrations of parasites (1.2 × 107, 6/3/1.5 × 106 cells/mL), then the concentrations of red blood ce...
Source: Experimental Parasitology - April 18, 2024 Category: Parasitology Authors: Carlos Vinicius Barros Oliveira Maria Elenilda Paulino da Silva Jailson Renato de Lima Amanda Maria Tavares Moreira Maria J éssica Mendes Brito Cicera Alane Coelho Gon çalves Jo ão Eudes Lemos de Barros Rom ário Matheus de Oliveira Jean Paul Kamdem Lu Source Type: research

< i > Ginkgo biloba < /i > attenuated detrimental inflammatory and oxidative events due to < i > Trypanosoma brucei rhodesiense < /i > in mice treated with melarsoprol
ConclusionUtilization of GB as an adjuvant therapy may ameliorate detrimental effects caused by T.b.r infection and MelB toxicity during late stage HAT. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 15, 2024 Category: Tropical Medicine Authors: Janet Khatenje Wendo Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research

Idiopathic Thrombocytosis in Alpha Thalassemia Trait Patient
We present here a case of microcytic hypochromic red blood cells and thrombocytosis in an adolescent female that we have monitored for three years. The patient was positive for alpha thalassemia trait; negative for mutation in Janus kinase 2, calreticulin, or myeloproliferative leukemia virus oncogene; and negative for reactive causes of thrombocytosis. Noticeably, a variant in atypical chemokine receptor 1 (ACKR1) (c.-67T>C, rs2814778) was found to be homozygous. Accordingly, the case was diagnosed as idiopathic thrombocytosis, and treatment was given to restore platelet levels to normal. Our findings highlight the pos...
Source: Annals of Clinical and Laboratory Science - March 21, 2024 Category: Laboratory Medicine Authors: Mohammed Makkawi Sultan Alasmari Obaid Albulym Husain Alkhaldy Source Type: research