Mesothelioma Clinical Trials Test Targeted Gene Therapy
For some patients, the future of mesothelioma cancer treatment may hinge on a pair of phase I clinical trials that opened earlier this year to study promising new drugs targeting specific genetic mutations. Precision medicine may finally be taking hold with malignant mesothelioma, clearing the path for significant, long-overdue advancements. The one-size-fits-all approach is fading. “There is some realistic hope now for patients,” Dr. Anthony Tolcher, co-founder of NEXT Oncology in San Antonio, told The Mesothelioma Center at Asbestos.com. “I am very optimistic. New avenues for treatment are opening up.” ...
Source: Asbestos and Mesothelioma News - June 21, 2022 Category: Environmental Health Authors: Fran Mannino Tags: Clinical Trials/Research/Emerging Treatments Source Type: news
Asbestos Abatement Laws Being Enforced
Cities and counties throughout the country are paying the price for failing to adhere to the tightening safety protocols that cover the handling and disposal of toxic asbestos in existing structures. Dothan, Alabama, became the latest city to pay for its negligence, agreeing to a $3,000 settlement with the state’s Department of Environmental Management, stemming from its failure to get a proper asbestos-abatement inspection. The city, which is in the middle of a downtown rebuilding project, demolished five structures recently, but only had one commercial building properly inspected. The other four were residential,...
Source: Asbestos and Mesothelioma News - June 17, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Asbestos (general) Source Type: news
Steve McQueen: The 'King of Cool's' deadly mesothelioma - critical warning signs
ACTOR STEVE McQueen can be seen in his prime as the 1968 crime thriller Bullitt airs on ITV4 tonight . As the legendary actor passed away back in 1980 aged only 50, here we examine the health issues he suffered leading up to his untimely death which included a battle with asbestos cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 14, 2022 Category: Consumer Health News Source Type: news
Novel Clinical Trial Helping Late-Stage Mesothelioma Patients
Late-stage patients with pleural mesothelioma have survived longer than anticipated — with good quality of life — in a phase I clinical trial studying the effectiveness of a novel combination treatment. The treatment involves galinpepimut-S, the latest targeted cancer vaccine also known as GPS, in combination with Opdivo, a popular immunotherapy drug. Memorial Sloan Kettering Cancer Center is hosting the study sponsored by SELLAS Life Sciences Group, a late-stage clinical biopharmaceutical company based in New York City. “We’ve seen some very, very positive results,” Dr. Dragan Cicic, director of Clinica...
Source: Asbestos and Mesothelioma News - June 14, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Clinical Trials/Research/Emerging Treatments Source Type: news
Sudden Rise in Asbestos Imports as Ban Draws Closer
Importation of raw chrysotile asbestos into the United States increased dramatically earlier this year, despite the growing movement toward tighter regulation and a potential future ban of the product. The chloralkali industry — the only known user of raw asbestos today within the U.S. — imported an estimated 114 metric tons over the first three months of 2022, according to the United States International Trade Commission. In all of 2021, by comparison, the industry imported only 100 metric tons, the smallest amount in more than half a century. This sudden and dramatic rise in imports stems from a stockpiling ...
Source: Asbestos and Mesothelioma News - June 9, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Asbestos (general) Source Type: news
Carbone: Building the Guide to BAP1 Mutation in Mesothelioma
Over the years, I have “collected” many families affected by the BAP1 cancer syndrome, a novel medical condition we discovered in 2011. Pathogenic germline mutations, most of them BAP1 mutations, are estimated to be found in 10% of all those diagnosed with mesothelioma. BAP1 germline mutations occur in people born with only one functioning copy of the BAP1 gene, while the other copy is mutated and inactive. The mutations make these people very susceptible to developing cancer, in particular mesothelioma and melanoma. On the bright side, when mesothelioma develops in carriers of germline BAP1 mutations, patients h...
Source: Asbestos and Mesothelioma News - May 31, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Clinical Trials/Research/Emerging Treatments Source Type: news
Targeted Therapy Making Progress with Pleural Mesothelioma
Future treatment of pleural mesothelioma cancer continued its move toward a more personalized, targeted approach with the latest results from a multi-center clinical trial involving tazemetostat, a novel protein inhibitor. Tazemetostat, also known as the brand name Tazverik, showed impressive effectiveness in a second line setting for patients with the BAP1 genetic mutation. The disease control rate for patients was 54.1% at 12 weeks and 32.8% at 24 weeks, numbers that exceeded expectations. There currently is no FDA-approved second-line treatment for pleural mesothelioma, an aggressive cancer with no cure caused pri...
Source: Asbestos and Mesothelioma News - May 24, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Clinical Trials/Research/Emerging Treatments Source Type: news
Veterans Getting Closer to Justice at Camp Lejeune
Veterans and their families who were exposed to the contaminated drinking water at Marine Corps Base Camp Lejeune in North Carolina may soon find the justice they have been seeking for many years. The U.S. Senate is expected to soon pass legislation that delivers more comprehensive health care and benefits to veterans affected by all toxic exposure during their service. The Honoring Our PACT Act, a broad, nationwide plan already passed in the House of Representatives, will include the Camp Lejeune Justice Act of 2022, which focuses on four decades of water contamination at the base and the serious health problems it ...
Source: Asbestos and Mesothelioma News - May 19, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Veterans Source Type: news
Increasing Numbers of Women Dying from Malignant Mesothelioma
The number of women dying annually from malignant mesothelioma climbed by 25% over the past two decades, despite a nationwide drop in the use of asbestos, the primary cause of the cancer. The rise in deaths among women contrasts with the numbers among men, which have fallen slightly in recent years, according to the U.S. Centers for Disease Control and Prevention. The statistics were part of the CDC’s Morbidity and Mortality Weekly Report published on May 13. The report analyzed the annual mesothelioma death rate for women from 1999 to 2020. “The increasing number of malignant mesothelioma deaths among women m...
Source: Asbestos and Mesothelioma News - May 17, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Asbestos Exposure Source Type: news
Number of Mesothelioma Deaths Up Among Women From 1999 to 2020
THURSDAY, May 12, 2022 -- From 1999 to 2020, there was an increase in the annual number of mesothelioma deaths among women, although the age-adjusted death rate decreased, according to research published in the May 13 issue of the U.S. Centers for... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 12, 2022 Category: Pharmaceuticals Source Type: news
Malignant Mesothelioma Mortality in Women - United States, 1999-2020
This report describes an increase in mesothelioma deaths among women from 1990 to 2020. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - May 12, 2022 Category: American Health Tags: Asbestos Cause of death MMWR Morbidity & Mortality Weekly Report Occupational Health Statistics Women's Health Source Type: news
CDC: Mesothelioma Deaths Up Among Women
(MedPage Today) -- While use of asbestos has gone down in the U.S., deaths from mesothelioma still increased 25% among women over the last two decades, researchers found. From 1999 to 2020, mesothelioma deaths among women rose significantly from... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - May 12, 2022 Category: American Health Source Type: news
EPA Proposes Stricter Asbestos Reporting
The United States Environmental Protection Agency has proposed a new rule that would require much stricter reporting and record keeping for all uses of asbestos throughout the past four years. The rule would require companies that manufacture or process asbestos-containing products to report all types of use, quantities of use and exposure-related information, much of which is not currently required. It also includes articles containing unintended impurities, such as talc products contaminated with asbestos fibers. According to the EPA, the data obtained will be used to more accurately guide the agency in future a...
Source: Asbestos and Mesothelioma News - May 11, 2022 Category: Environmental Health Authors: Sophia Clifton Tags: Asbestos (general) Source Type: news
New Mesothelioma Immunotherapy Clinical Trial Opens at MD Anderson
The acclaimed MD Anderson Cancer Center in Houston is opening a phase II clinical trial involving a new immunotherapy drug aimed specifically at advanced, rare cancers, including both pleural and peritoneal mesothelioma. This single-institution clinical trial will be measuring the safety and effectiveness of vudalimab, also known as XmAb20717, which was designed by the California-based biopharmaceutical company Xencor. Vudalimab’s uniqueness stems from its ability to block the activation of cell surface proteins PD-1 and CTLA-4. These proteins stop the immune system from working properly and promote T-cell acti...
Source: Asbestos and Mesothelioma News - May 11, 2022 Category: Environmental Health Authors: Fran Mannino Tags: Clinical Trials/Research/Emerging Treatments Source Type: news
Johnson & Johnson To Continue Global Sale of Talc-Based Baby Powder
Johnson & Johnson will continue selling its iconic talc-based baby powder outside the United States and Canada after shareholders rejected a proposal that would have ended its worldwide production and distribution. The proposal failed to receive the majority vote needed at J&J’s annual meeting of stockholders last month, which was held virtually due to the COVID-19 pandemic. Ending global sales was one of 14 issues – and the most controversial – listed in the company’s proxy statement. J&J discontinued selling Johnson’s Baby Powder throughout the U.S. and Canada in 2020 after being flooded with ...
Source: Asbestos and Mesothelioma News - May 9, 2022 Category: Environmental Health Authors: Fran Mannino Tags: Asbestos Exposure Source Type: news