Australasian Malignant PLeural Effusion (AMPLE)-3 trial: study protocol for a multi-centre randomised study comparing indwelling pleural catheter ( ±talc pleurodesis) versus video-assisted thoracoscopic surgery for management of malignant pleural effusion
DiscussionBoth IPC and VATS are commonly used procedures for MPE. The AMPLE-3 trial will provide data to help define the merits and shortcomings of these procedures and inform future clinical care algorithms.Trial registrationAustralia New Zealand Clinical Trial RegistryACTRN12618001013257. Registered on 18 June 2018.Protocol version: Version 3.00/4.02.19 (Source: Trials)
Source: Trials - June 27, 2022 Category: Research Source Type: clinical trials

Immunological Variables Associated to ICI Toxicity in Cancer Patients
Conditions:   Breast Cancer;   Melanoma;   Non Small Cell Lung Cancer;   Non-melanoma Skin Cancer;   Gastrointestinal Cancer;   Head and Neck Cancer;   Renal Cell Carcinoma;   Small Cell Lung Cancer;   Mesothelioma, Malignant;   Bladder Cancer;   Merkel Cell Carcinoma;   Hepatoc ellular Carcinoma;   MSI-H Colorectal Cancer Intervention:   Drug: Checkpoint Blockade, Immune Sponsor:   Jules Bordet Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 23, 2022 Category: Research Source Type: clinical trials

OT-101 in Combination With Pembrolizumab in Subjects With Malignant Pleural Mesothelioma Failing to Respond to Checkpoint Inhibition
Condition:   Malignant Pleural Mesothelioma Intervention:   Drug: OT-101 Sponsor:   Oncotelic Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 21, 2022 Category: Research Source Type: clinical trials