RE: Wang, D. (2023). Re: comparison of retrograde intrarenal stone surgery with and without a ureteral access sheath using kidney injury molecule-1 (KIM-1) levels: a prospective randomized study by G ökhan Ecer, Mehmet Giray Sönmez, Arif Aydın, Cemile Topçu, Haider Nihad Izaddin Alalam, Selçuk Güven, and Mehmet Balasar. Urolithiasis, 51(1), 44
(Source: Urolithiasis)
Source: Urolithiasis - May 3, 2023 Category: Urology & Nephrology Source Type: research
A randomized controlled study of ureteral stent extraction string on patient ’s quality of life and stent-related complications after percutaneous nephrolithotomy in the prone position
AbstractTo demonstrate the Tianjin Institute of Urology (TJIU) technique to place and remove the ureteral stent with extraction string after percutaneous nephrolithotomy (PCNL). Additionally, we aim to compare the pain experienced during stent removal, quality of life during stent retention, and stent-related complications between patients with and without extraction string. 65 patients were included in the final analysis in the string group constructed by the TJIU technique and 66 patients in the conventional double-J ureteral stent (non-string) group. All patients underwent the surgery in a prone position under general a...
Source: Urolithiasis - April 28, 2023 Category: Urology & Nephrology Source Type: research
Nedosiran in primary hyperoxaluria subtype 3: results from a phase I, single-dose study (PHYOX4)
Abstract
Nedosiran is anN-acetyl-D-galactosamine (GalNAc) –conjugated RNA interference agent targeting hepatic lactate dehydrogenase (encoded by theLDHA gene), the putative enzyme mediating the final step of oxalate production in all three genetic subtypes of primary hyperoxaluria (PH). This phase I study assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of subcutaneous nedosiran in patients with PH subtype 3 (PH3) and an estimated glomerular filtration rate ≥ 30 mL/min/1.73 m2. Single-dose nedosiran 3 mg/kg or placebo was administered in a randomized (2:1), double-blinded manner. Safet...
Source: Urolithiasis - April 28, 2023 Category: Urology & Nephrology Source Type: research
A randomized controlled study of ureteral stent extraction string on patient ’s quality of life and stent-related complications after percutaneous nephrolithotomy in the prone position
AbstractTo demonstrate the Tianjin Institute of Urology (TJIU) technique to place and remove the ureteral stent with extraction string after percutaneous nephrolithotomy (PCNL). Additionally, we aim to compare the pain experienced during stent removal, quality of life during stent retention, and stent-related complications between patients with and without extraction string. 65 patients were included in the final analysis in the string group constructed by the TJIU technique and 66 patients in the conventional double-J ureteral stent (non-string) group. All patients underwent the surgery in a prone position under general a...
Source: Urolithiasis - April 28, 2023 Category: Urology & Nephrology Source Type: research
Nedosiran in primary hyperoxaluria subtype 3: results from a phase I, single-dose study (PHYOX4)
Abstract
Nedosiran is anN-acetyl-D-galactosamine (GalNAc) –conjugated RNA interference agent targeting hepatic lactate dehydrogenase (encoded by theLDHA gene), the putative enzyme mediating the final step of oxalate production in all three genetic subtypes of primary hyperoxaluria (PH). This phase I study assessed the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of subcutaneous nedosiran in patients with PH subtype 3 (PH3) and an estimated glomerular filtration rate ≥ 30 mL/min/1.73 m2. Single-dose nedosiran 3 mg/kg or placebo was administered in a randomized (2:1), double-blinded manner. Safet...
Source: Urolithiasis - April 28, 2023 Category: Urology & Nephrology Source Type: research
Professor Fazil Marickar (12 November 1948 –22 March 2023)
(Source: Urolithiasis)
Source: Urolithiasis - April 26, 2023 Category: Urology & Nephrology Source Type: research
Hormonal and molecular characterization of calcium oxalate stone formers predicting occurrence and recurrence
AbstractThe purpose of the study is to investigate the role of sex hormones, androgen receptors (ARs) and miRNA/CSF-1 in occurrence and recurrence of calcium oxalate (CaOx) renal urolithiasis. In this prospective study, 74 patients with CaOx stones; stone formers group (SFG) and 40 healthy subjects; control group were compared. SFG includes both de novo and recurrent cases. Steroid sex hormone plasma assay including testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin was analyzed. ARs, miRNA-185-5p and CSF-1 expression were compared between the groups. SFG showed significant hi...
Source: Urolithiasis - April 24, 2023 Category: Urology & Nephrology Source Type: research
Stone attenuation on computer tomography helps surgeons make decisions between miniaturized percutaneous nephrolithotomy or retrograde intrarenal surgery for lower pole stones: a retrospective study
AbstractA retrospective study was performed on 200 patients who underwent miniaturized percutaneous nephrolithotomy (mini-PCNL) or retrograde intrarenal surgery (RIRS) for 10 –20 mm sized lower pole renal calculi to investigate the relationship between computed tomography (CT) attenuation of calculi and surgical outcomes. CT was used to examine the location, size, and CT attenuation values of the calculi. Additionally, the operation time, hospital stay, hemoglobin (Hb ) reduction, stone-free rate (SFR), and complication rate were also meticulously documented and subjected to comparative analysis. Complications were asse...
Source: Urolithiasis - April 24, 2023 Category: Urology & Nephrology Source Type: research
Hormonal and molecular characterization of calcium oxalate stone formers predicting occurrence and recurrence
AbstractThe purpose of the study is to investigate the role of sex hormones, androgen receptors (ARs) and miRNA/CSF-1 in occurrence and recurrence of calcium oxalate (CaOx) renal urolithiasis. In this prospective study, 74 patients with CaOx stones; stone formers group (SFG) and 40 healthy subjects; control group were compared. SFG includes both de novo and recurrent cases. Steroid sex hormone plasma assay including testosterone, free testosterone, dihydrotestosterone, estradiol, and sex hormone binding globulin was analyzed. ARs, miRNA-185-5p and CSF-1 expression were compared between the groups. SFG showed significant hi...
Source: Urolithiasis - April 24, 2023 Category: Urology & Nephrology Source Type: research
Stone attenuation on computer tomography helps surgeons make decisions between miniaturized percutaneous nephrolithotomy or retrograde intrarenal surgery for lower pole stones: a retrospective study
AbstractA retrospective study was performed on 200 patients who underwent miniaturized percutaneous nephrolithotomy (mini-PCNL) or retrograde intrarenal surgery (RIRS) for 10 –20 mm sized lower pole renal calculi to investigate the relationship between computed tomography (CT) attenuation of calculi and surgical outcomes. CT was used to examine the location, size, and CT attenuation values of the calculi. Additionally, the operation time, hospital stay, hemoglobin (Hb ) reduction, stone-free rate (SFR), and complication rate were also meticulously documented and subjected to comparative analysis. Complications were asse...
Source: Urolithiasis - April 24, 2023 Category: Urology & Nephrology Source Type: research
Use of Moses 2.0 with extended frequency and optimized Moses vs. high-power laser in MiniPCNL: a randomized controlled trial
AbstractThe aim of the study was to compare standard high-power laser (with < 80 Hz) to extended frequency (> 100 Hz) lithotripsy during miniPCNL. 40 patients were randomized in to two groups undergoing MiniPCNL. For both groups, the Holmium Pulse laser Moses 2.0 (Lumenis) was used. For group A, standard high-power laser with < 80 Hz, with Moses distance was set using up to 3 J. For Group B, extended frequency (100–120 Hz) was used allowing up to 0.6 J. All patients underwent MiniPCNL using an 18 Fr balloon access. Demographics were comparable between groups. Mean stone diameter was 19 mm (1...
Source: Urolithiasis - April 19, 2023 Category: Urology & Nephrology Source Type: research
Stone-event-free survival after ureteroscopic lithotripsy by age: comparison between young and older patients
In conclusion, stone-event-free survival after URSL wa s comparable between young and older patients. Residual fragment > 4 mm and stone burden ≥ 15 mm were common risk factors in both groups. Preoperative stenting was an additional risk factor in older patients, suggesting that urinary tract infection may influence stone events. (Source: Urolithiasis)
Source: Urolithiasis - April 18, 2023 Category: Urology & Nephrology Source Type: research
