Effect of a high-citrate beverage on urine chemistry in patients with calcium kidney stones
AbstractA well-accepted strategy to prevent kidney stones is to increase urine volume by increasing oral intake of fluids, especially water, to lower supersaturation of the relevant, relatively insoluble salts, and thereby lower the risk of precipitation. Randomized controlled trials have shown that this strategy works. It is inexpensive, safe, and intuitively attractive to patients. However, although any beverage can increase urine volume, and citrus juices can increase urine citrate content and pH, no beverage other than water has been clearly shown by randomized controlled trial to prevent kidney stones. We designed an ...
Source: Urolithiasis - July 21, 2023 Category: Urology & Nephrology Source Type: research

The altered composition of gut microbiota and biochemical features as well as dietary patterns in a southern Chinese population with recurrent renal calcium oxalate stones
AbstractThe correlation among gut microbiota, biochemical features, and dietary patterns in recurrent stone formers has been inadequately investigated in the Chinese population. Forty-two patients with calcium oxalate stones (CaOxS group), including 34 recurrent stone formers (RS group), and 40 nonstone healthy subjects (NS group) from Changshu Hospital Affiliated with Soochow University, were prospectively recruited. Food frequency questionnaires were completed by participants, fasting vein blood was extracted, 24-h urine was collected for biochemical detection, and fecal samples were gathered for 16S ribosomal RNA (rRNA)...
Source: Urolithiasis - July 17, 2023 Category: Urology & Nephrology Source Type: research

Interpretation of SLC3A1 and SLC7A9 variants in cystinuria patients: The significance of the PM3 criterion and protein stability
AbstractCystinuria is a genetic disorder caused by defects in the b0,+ transporter system, which is composed of rBAT and b0,+AT coded bySLC3A1 andSLC7A9, respectively. Variants inSLC3A1 andSLC7A9 follow autosomal recessive inheritance and autosomal dominant inheritance with reduced penetrance, respectively, which complicates the interpretation of cystinuria-related variants. Here, we report seven differentSLC3A1 variants and six differentSLC7A9 variants. Among these variants were two novel variants previously not reported:SLC3A1 c.223C  >  T andSLC7A9 c.404A  >  G. In silico analysis using REVEL correlated we...
Source: Urolithiasis - July 13, 2023 Category: Urology & Nephrology Source Type: research

The effect of bioelectric impedance analysis on the success of extracorporeal shock wave lithotripsy
In this study, we aimed to determine the effect of BIA on extracorporeal shock wave lithotripsy (SWL) success. Our secondary aim was to determine the factors predicting transition from a single SWL session to multiple sessions. Patients who underwent SWL due to kidney stones were prospectively included. Demographics, pre-procedural BIA parameters (fat percentage, obesity degree, muscle mass, total water and metabolic rate), stone parameters, and number of SWL sessions were recorded. Univariate and multivariate regression analyzes were made to determine independent risk factors for success. Then, the successful group was di...
Source: Urolithiasis - July 4, 2023 Category: Urology & Nephrology Source Type: research

Correction to: Efficacy and safety of surgical treatment for 1 –2 cm sized lower pole of renal stone: network meta-analysis of randomized control trials
(Source: Urolithiasis)
Source: Urolithiasis - July 3, 2023 Category: Urology & Nephrology Source Type: research

Living donor-gifted allograft lithiasis: surgical experience after bench surgery stone removal and follow-up
This study presents the surgical experience and long-term outcomes of living donor kidney transplantations involving asymptomatic kidney stones, using ex vivo flexible ureterorenoscopy (f-URS) during bench surgery for stone removal. Out of 1743 living kidney donors assessed between January 2012 and October 2022, 18 (1%) were diagnosed with urolithiasis. Among them, 12 donors were rejected, and 6 were accepted for kidney donation. Stone removal was successfully performed using f-URS during bench surgery, with no immediate complications or acute rejections observed. The study analyzed six living kidney transplants, of which ...
Source: Urolithiasis - June 26, 2023 Category: Urology & Nephrology Source Type: research

Enhanced popcorning using polyanionic chelating solutions as irrigation
AbstractPoly-anionic compounds can chelate divalent cations and dissolve calcium oxalate stone. Our objective was to assess how much concurrent irrigation with poly-anionic chelating solutions during non-contact laser lithotripsy or popcorning could improve stone ablation rate. A popcorning model was created by lowering a ureteroscope with thulium fiber laser into a test tube calyx. Begostones of matching size and mass were placed in the test tube and treated with the laser while irrigating with different iso-osmolar poly-anionic solutions. We compared 0.9% sodium chloride (NaCl), sodium citrate, sodium hexa-metaphosphate,...
Source: Urolithiasis - June 23, 2023 Category: Urology & Nephrology Source Type: research

Using vacuum-assisted ureteral access sheath in the treatment of complex steinstrasse
AbstractSteinstrasse is an iatrogenic condition resulting from upper urinary tract lithotripsy. Uncomplicated steinstrasse can be managed expectantly. Complex steinstrasse can pose a therapeutic challenge. The vacuum-assisted ureteral access sheath (vaUAS) is similar to a conventional ureteral access sheath but has a side branch that can be connected to vacuum apparatus. This device seemed to be useful in the management of complex steinstrasse. 35 patients with complex steinstrasse, defined as steinstrasse containing  ≥ 4 stones or with an aggregate length of ≥ 1.5 cm, were treated in four tertiary medical cen...
Source: Urolithiasis - June 22, 2023 Category: Urology & Nephrology Source Type: research