Treatment of donors ’ asymptomatic small kidney stones and post-transplant outcomes: a meta-analysis
AbstractKidney donors with asymptomatic small kidney stones were increasingly accepted in kidney transplantation (KT) due to organ shortage and advances in endoscopic urology. However, recipients ’ clinical outcomes using these donors remained unclear. We conducted a meta-analysis to summarize transplant outcomes using these donors with asymptomatic small kidney stones. Finally, 15 retrospective studies were included. The prevalence of asymptomatic small kidney stones was 5.3% (95%CI 3.5– 7.8%). After transplantation, low incidence of urinary fistula (0%, 95%CI 0–1.0%), obstruction (0%, 95%CI 0–1.1%), relapse of ki...
Source: Urolithiasis - August 16, 2023 Category: Urology & Nephrology Source Type: research
Association between alcohol and urolithiasis: a mendelian randomization study
In this study, we aimed to investigate the causal relationship between alcohol and kidney stones using a two-sample MR approach. Two sets of genetic instruments were utilized in the analysis, both of which were derived from publicly available genetic summary data. The first set consisted of 73 single-nucleotide polymorphisms (SNPs) robustly linked to alcohol intake frequency (AIF) and the second set was comprised of 69 SNPs associated with alcohol consumption (AC). Our MR analysis was performed using several methods including the inverse-variance weighted (IVW) method, weighted median method, MR-Egger regression, MR Pleiot...
Source: Urolithiasis - August 15, 2023 Category: Urology & Nephrology Source Type: research
Which position is more advantageous for percutaneous nephrolithotomy: supine or prone?
AbstractPercutaneous nephrolithotomy (PNL) can be performed in a number of different positions. Our aim was to evaluate the convenience and advantages of the supine position following the transition from the prone to the supine position. 94 patients undergoing supine PNL (Group-1) and 93 patients undergoing prone PNL (Group-2) were retrospectively reviewed and included in the study. Patients who underwent mini-PNL (mPNL) were selected from Group-1 and Group-2 and divided into Group-1A supine mPNL patients (77) and Group-2A prone mPNL patients (53). Demographic characteristics, operative data and post-operative parameters w...
Source: Urolithiasis - August 14, 2023 Category: Urology & Nephrology Source Type: research
Population genetics analysis of SLC3A1 and SLC7A9 revealed the etiology of cystine stone may be more than what our current genetic knowledge can explain
ConclusionThe clinical prevalence of cystine stone has been previously reported as 1 in 7,000, a notably higher figure than the genetic prevalence of 1 in 30,585 calculated in this study. This suggests that the etiology of cystine stone is more complex than what our current genetic knowledge can explain. Possible factors that may contribute to this difference include novel causal genes, undiscovered pathogenic variants, alternative inheritance models, founder effects, epigenetic modifications, environmental factors, or other modifying factors. Further investigation is needed to fully understand the etiology of cystine ston...
Source: Urolithiasis - August 10, 2023 Category: Urology & Nephrology Source Type: research
Residual fragment size following retrograde intrarenal surgery: a critical evaluation of related variables
AbstractGiven the limited data on the predictive factors of residual kidney stone size after flexible ureteroscopy (fURS), this study aims to investigate the variables affecting residual stone size. The medical records of 642 patients without complications being treated for kidney stones with fURS between July 2014 and May 2022 were reviewed retrospectively, and the information of the 170 patients in whom residual stones were found was recorded. In addition to patient-specific factors and stone characteristics, length of postoperative hospital stay, postoperative fever, and preoperative antiaggregant use were evaluated. Of...
Source: Urolithiasis - August 9, 2023 Category: Urology & Nephrology Source Type: research
Anatomical approach to PCNL: concept of ideal puncture zone in a 3D perspective
AbstractTo describe a concept of ideal ‘puncture zone’ as against any single ideal ‘puncture tract’ for percutaneous nephro-lithotomy (PCNL) and present our results. Through this narrative, we aim to reduce the gaps in inter-understanding of an erstwhile description of ideal tract and real-life puncture making. The puncture zone principle was applied for our novel puncture making technique during PCNL. The largest imaginary cone that can fit into a respective calyx, with its tip in the pelvis defines the ‘puncture zone’ for that calyx. This concept allows fine-tuning of the ideal puncture tract based upon the d...
Source: Urolithiasis - August 9, 2023 Category: Urology & Nephrology Source Type: research
Residual fragment size following retrograde intrarenal surgery: a critical evaluation of related variables
AbstractGiven the limited data on the predictive factors of residual kidney stone size after flexible ureteroscopy (fURS), this study aims to investigate the variables affecting residual stone size. The medical records of 642 patients without complications being treated for kidney stones with fURS between July 2014 and May 2022 were reviewed retrospectively, and the information of the 170 patients in whom residual stones were found was recorded. In addition to patient-specific factors and stone characteristics, length of postoperative hospital stay, postoperative fever, and preoperative antiaggregant use were evaluated. Of...
Source: Urolithiasis - August 9, 2023 Category: Urology & Nephrology Source Type: research
Anatomical approach to PCNL: concept of ideal puncture zone in a 3D perspective
AbstractTo describe a concept of ideal ‘puncture zone’ as against any single ideal ‘puncture tract’ for percutaneous nephro-lithotomy (PCNL) and present our results. Through this narrative, we aim to reduce the gaps in inter-understanding of an erstwhile description of ideal tract and real-life puncture making. The puncture zone principle was applied for our novel puncture making technique during PCNL. The largest imaginary cone that can fit into a respective calyx, with its tip in the pelvis defines the ‘puncture zone’ for that calyx. This concept allows fine-tuning of the ideal puncture tract based upon the d...
Source: Urolithiasis - August 9, 2023 Category: Urology & Nephrology Source Type: research
Effect of outflow resistance on intrarenal pressure at different irrigation rates during ureteroscopy: in vivo evaluation
In this study, we sought to characterize the IRP as a function of irrigation rate in an in vivo porcine model at different outflow resistances. Ureteroscopy was performed in a porcine model with a 9.5 Fr prototype ureteroscope containing a pressure sensor. A modified ureteral access sheath (UAS) (11/13 Fr, 36  cm) was configured to adjust outflow resistance. IRP–irrigation rate curves were generated at four different outlet resistances representing different outflow scenarios. At lower irrigation rates, the pressure change in response to increased irrigation was gradual and non-linear, likely reflecti ng a “compliantâ...
Source: Urolithiasis - July 29, 2023 Category: Urology & Nephrology Source Type: research
Practices and utility of imaging among urological communities for urolithiasis, observations, and inferences from a targeted survey
AbstractTo evaluate the general practice among urologists about the use of various radiological imaging and measurement tools, and to compare the different preferences in radiological evaluations between Turkish and European urologists. Our study was designed as a survey study. The survey comprised 22 questions which evaluated the epidemiological information, caseload of participants, general preferences of participants on CT image slice thickness, basic radiologic workup routines prior to surgery, use of special tools and measurements on CT. Data collection was conducted with both an online poll and printed copies. A tota...
Source: Urolithiasis - July 25, 2023 Category: Urology & Nephrology Source Type: research
