Transactions of the American Clinical and Climatological Association This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The gordon wilson lecture: rapid covid-19 vaccine development and the future of vaccinology
Trans Am Clin Climatol Assoc. 2023;133:103-105.NO ABSTRACTPMID:37701620 | PMC:PMC10493744 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Barney S Graham Source Type: research

The jeremiah metzger lecture: turning genes into medicines: highlights and hurdles in the development of gene therapy for genetic disease
Trans Am Clin Climatol Assoc. 2023;133:204-233.ABSTRACTThe journey from in vitro transfer of genes into mammalian cells to approved gene therapy products has spanned decades. This manuscript summarizes hurdles encountered and obstacles overcome in the development of successful adeno-associated viral (AAV) vectors for hemophilia B and for an inherited retinal dystrophy caused by mutations in the RPE65 gene. In the case of hemophilia B, careful analysis of the first unsuccessful attempts led to the realization that the human immune response to AAV vectors was preventing durable expression; elucidation of the response to the ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Katherine A High Source Type: research

Deceased Members 1884 through 2022
Trans Am Clin Climatol Assoc. 2023;133:xvi-xxvii.NO ABSTRACTPMID:37701579 | PMC:PMC10493732 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

American clinical and climatological association meeting locations 1884-2022
Trans Am Clin Climatol Assoc. 2023;133:xlix-l.NO ABSTRACTPMID:37701581 | PMC:PMC10493754 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Glucocorticoids in chronic disease: the good, the bad, the bone
Trans Am Clin Climatol Assoc. 2023;133:69-80.ABSTRACTDespite the advent of more targeted therapies, glucocorticoids (steroids) remain in chronic use (defined as > 3 months or more) by an estimated 0.5% of the population. Steroids yield symptomatic benefits for systemic and local inflammation as well as disease-modifying properties in rheumatoid arthritis, the most common disorder for their chronic use. Despite their many benefits, steroids have been associated with a myriad of common side effects. Observational studies of steroid safety are limited by confounding by indication, and randomized controlled trials have been...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Kenneth G Saag Source Type: research

Present Members
Trans Am Clin Climatol Assoc. 2023;133:xli-xlviii.NO ABSTRACTPMID:37701584 | PMC:PMC10493761 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Winners of the theodore e. woodward award
Trans Am Clin Climatol Assoc. 2023;133:160-161.NO ABSTRACTPMID:37701585 | PMC:PMC10493735 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Recorder's Report
Trans Am Clin Climatol Assoc. 2023;133:lxxxii-lxxxiii.NO ABSTRACTPMID:37701586 | PMC:PMC10493751 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

The jeremiah metzger lecture
Trans Am Clin Climatol Assoc. 2023;133:201-203.NO ABSTRACTPMID:37701587 | PMC:PMC10493714 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Microvascular endothelial activation/dysfunction and dysregulation of the angiopoietin-tie2 system in the pathogenesis of life-threatening infections
Trans Am Clin Climatol Assoc. 2023;133:234-246.ABSTRACTMicrovascular endothelial activation/dysfunction has emerged as an important mechanistic pathophysiological process in the development of morbidity and mortality in life-threatening infections. The angiopoietin-Tie2 system plays an integral role in the regulation of microvascular endothelial integrity. Angiopoietin-1 (Ang-1), produced by platelets and pericytes, is the cognate agonistic ligand for Tie2, promoting endothelial quiescence and inhibiting microvascular leak. Angiopoietin-2 (Ang-2), released from activated endothelial cells in Weibel-Palade bodies, competes ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: W Conrad Liles Source Type: research

Biological antiarrhythmics-sodium channel interacting proteins
Trans Am Clin Climatol Assoc. 2023;133:136-148.ABSTRACTVoltage gated Na channels (NaV) are essential for excitation of tissues. Mutations in NaVs cause a spectrum of human disease from autism and epilepsy to cardiac arrhythmias to skeletal myotonias. The carboxyl termini (CT) of NaV channels are hotspots for disease-causing mutations and are richly invested with protein interaction sites. We have focused on the regulation of NaV by two proteins that bind in this region: calmodulin (CaM) and non-secreted fibroblast growth factors (iFGF or FHF). CaM regulates NaV gating, mediating Ca2+-dependent inactivation (CDI) in a chann...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Gordon F Tomaselli Source Type: research

Dyspnea and mechanical ventilation: applying physiology to guide therapy
Trans Am Clin Climatol Assoc. 2023;133:162-180.ABSTRACTWhile advances in our understanding of mechanical ventilation have improved mortality from acute respiratory distress syndrome, recent studies indicate a rising incidence of post-ventilation mental health sequelae, including post-traumatic stress disorder (PTSD). Concurrent research on the physiology of dyspnea provides insights about the role of multiple sources of sensory information underlying respiratory discomfort along with the contribution of efferent-afferent dissociation to dyspnea, and the subsequent relationship of dyspnea to a range of affective responses, ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Richard M Schwartzstein Rachel Sturley Source Type: research

Closing the gap between medical knowledge and patient outcomes through new training infrastructure
This article describes why application and recognition of PI science as a discipline is imperative and why we should require training with similar intensity in undergraduate medical education (UME) and graduate medical education (GME). It also proposes investment in infrastructure (developing faculty expertise) and rigorous fellowships, which are, perhaps, more likely to thrive in teaching hospitals with a strong clinical mission.PMID:37701592 | PMC:PMC10493721 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Melvin Blanchard Source Type: research

Reaffirming the core values of academic cardiology
Trans Am Clin Climatol Assoc. 2023;133:93-98.ABSTRACTAcademic medical centers are rapidly evolving into academic health systems with expanding clinical activity. These changes coupled with financial pressures due to decreased clinical reimbursements and failure of the NHLBI budget to keep pace with inflation are challenging the ability to succeed in all our missions. New governance structures and financial models may be necessary to success in our research and educational missions.PMID:37701594 | PMC:PMC10493749 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Joaquin E Cigarroa Richard A Lange Source Type: research

Improving diverse participation in cancer clinical trials
Trans Am Clin Climatol Assoc. 2023;133:149-156.ABSTRACTDespite significant improvement in overall cancer mortality (>30% since 1991), these survival benefits have not been experienced by all groups uniformly especially in those of diverse heritage. Drivers of cancer health inequity are multi-factorial including more adverse social determinants of health, later stage cancer presentation, decreased health care access, decreased health literacy, and cultural barriers to prompt cancer care. Adding to these disparities is the historical inclusion of primarily well-insured Caucasian patients into cancer clinical trials leadin...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Ruben Mesa Rebecca T Jones Source Type: research