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Fgf23 and altered mineral homeostasis in kidney disease and following intravenous iron
Trans Am Clin Climatol Assoc. 2023;133:262-273.ABSTRACTFibroblast growth factor 23 (FGF23) is an endocrine hormone that stimulates renal phosphate excretion and suppresses circulating concentrations of 1,25-dihydroxyvitamin D (1,25D). These effects of FGF23 are most evident in rare diseases that are characterized by FGF23-mediated hypophosphatemic rickets-osteomalacia. More commonly, elevated FGF23 is a ubiquitous, early consequence of chronic kidney disease (CKD) in which it helps to maintain normal serum phosphate levels but causes secondary hyperparathyroidism by suppressing 1,25D, and directly promotes cardiovascular d...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Myles Wolf Source Type: research

Born to wheeze or learned when we were young: maternal and environmental factors influence atopic risk
Trans Am Clin Climatol Assoc. 2023;133:181-192.ABSTRACTThe prevalence of atopic diseases is increasing globally, particularly in children. Heritable genetics can partially explain risk of disease. Evidence also points to acquired genetic material, in the form of the microbiome, as an important factor in disease pathogenesis. The acquisition of the microbiome dynamically changes in response to differences in lifestyle and environmental factors. Also, in utero, maternal and environmental factors influence atopic risk for allergic rhinitis, eczema, asthma, and food allergy. Combining the analytical power of omics, we focus on...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Patricia W Finn David L Perkins Source Type: research

Impact of the covid-19 pandemic on public hospitals in the united states
This study highlights the need to expand funding and support for the nation's essential hospitals.PMID:37701611 | PMC:PMC10493752 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Will Ross Matt Reidhead Robert Jansen Cynthia Boyd Elvin Geng Source Type: research

Winners of the mary allen engle award
Trans Am Clin Climatol Assoc. 2023;133:158.NO ABSTRACTPMID:37701612 | PMC:PMC10493731 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Integrins: a bedside to bench to bedside story
Trans Am Clin Climatol Assoc. 2023;133:34-55.ABSTRACTI provide a narrative of the path I took to discover the membrane receptors that mediate leukocyte adhesion, now known as β2 integrins or CD11/CD18. We followed this discovery with the first determination of the 3-D structures of integrins. The latter advance provided the foundation for understanding the unique features of integrins as divalent cation-dependent signaling receptors and as mechanosensitive conduits between the extracellular matrix and the intracellular cytoskeleton. Our structural studies are now opening new paths for taming overactive integrins in diseas...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: M Amin Arnaout Source Type: research

Eliminating the race coefficient in kidney function estimating equations: the center did hold
Trans Am Clin Climatol Assoc. 2023;133:247-261.ABSTRACTDr. Chi-yuan Hsu describes controversies surrounding the race coefficient ("if African American") in widely used kidney function estimating equations. He outlines recent research results on this topic by himself and others and comments on the relationship between activists and the academic medical community.PMID:37701614 | PMC:PMC10493757 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Chi-Yuan Hsu Source Type: research

Former Officers 1884 Through 2022
Trans Am Clin Climatol Assoc. 2023;133:viii-xiv.NO ABSTRACTPMID:37701615 | PMC:PMC10493747 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

The Jeremiah Metzger Lecture
Trans Am Clin Climatol Assoc. 2023;133:200.NO ABSTRACTPMID:37701616 | PMC:PMC10493725 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Clinical heterogeneity in the age of big data, advanced analytics, and complexity theory
Trans Am Clin Climatol Assoc. 2023;133:56-68.ABSTRACTClinical heterogeneity remains a challenge in the practice of medicine and is an underlying motivation for much of biomedical research. Unfortunately, despite an abundance of technologies capable of producing millions of discrete data elements with information about a patient's health status or disease prognosis, our ability to translate those data into meaningful improvements in understanding of clinical heterogeneity is limited. To address this gap, we have applied newer approaches to manifold learning and developed additional and complementary techniques to interrogat...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: David Herrington Yue Wang Source Type: research

The bert and peggy dupont lecture: tuberculosis and the building of the american west
Trans Am Clin Climatol Assoc. 2023;133:196-199.NO ABSTRACTPMID:37701618 | PMC:PMC10493767 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Eric J Rubin Source Type: research

The gordon wilson lecture: rapid covid-19 vaccine development and the future of vaccinology
Trans Am Clin Climatol Assoc. 2023;133:103-105.NO ABSTRACTPMID:37701620 | PMC:PMC10493744 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Barney S Graham Source Type: research

The jeremiah metzger lecture: turning genes into medicines: highlights and hurdles in the development of gene therapy for genetic disease
Trans Am Clin Climatol Assoc. 2023;133:204-233.ABSTRACTThe journey from in vitro transfer of genes into mammalian cells to approved gene therapy products has spanned decades. This manuscript summarizes hurdles encountered and obstacles overcome in the development of successful adeno-associated viral (AAV) vectors for hemophilia B and for an inherited retinal dystrophy caused by mutations in the RPE65 gene. In the case of hemophilia B, careful analysis of the first unsuccessful attempts led to the realization that the human immune response to AAV vectors was preventing durable expression; elucidation of the response to the ...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Katherine A High Source Type: research

Deceased Members 1884 through 2022
Trans Am Clin Climatol Assoc. 2023;133:xvi-xxvii.NO ABSTRACTPMID:37701579 | PMC:PMC10493732 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

American clinical and climatological association meeting locations 1884-2022
Trans Am Clin Climatol Assoc. 2023;133:xlix-l.NO ABSTRACTPMID:37701581 | PMC:PMC10493754 (Source: Transactions of the American Clinical and Climatological Association)
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Source Type: research

Glucocorticoids in chronic disease: the good, the bad, the bone
Trans Am Clin Climatol Assoc. 2023;133:69-80.ABSTRACTDespite the advent of more targeted therapies, glucocorticoids (steroids) remain in chronic use (defined as > 3 months or more) by an estimated 0.5% of the population. Steroids yield symptomatic benefits for systemic and local inflammation as well as disease-modifying properties in rheumatoid arthritis, the most common disorder for their chronic use. Despite their many benefits, steroids have been associated with a myriad of common side effects. Observational studies of steroid safety are limited by confounding by indication, and randomized controlled trials have been...
Source: Transactions of the American Clinical and Climatological Association - September 13, 2023 Category: General Medicine Authors: Kenneth G Saag Source Type: research