Surgical Oncology Clinics of North America This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Nonoperative Management of Rectal Cancer
In recent decades, rectal cancer management has become increasingly challenging for multiple reasons. Proper imaging using dedicated magnetic resonance, standardization of total mesorectal excision, and incorporation of neoadjuvant treatment regimens have contributed to a significant decrease in local recurrence rates. The observation of complete tumor response to radiation or chemoradiation led to the proposal of organ-preservation strategies with avoidance of immediate surgery and close surveillance (Watch and Wait strategy) in selected patients. The purpose of this article is to review the current evidence related to th...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Bruna Borba Vailati, Guilherme Pagin S ão Julião, Angelita Habr-Gama, Rodrigo Oliva Perez Source Type: research

Local Excision and Endoscopic Strategies for the Treatment of Colorectal Cancer
Local excision and endoluminal surgery are organ preservation techniques, which are more widely accepted and practiced in colorectal cancer management. Although endoluminal surgery is considered challenging, it will continue to progress and gain more popularity over time. Increased education, research, and availability of the tools to perform these procedures will help more endoscopists be adept over time. Owing to the ability to avoid intraabdominal surgery, endoluminal surgery can be the next big step for minimally invasive surgery. Through research and development, fully flexible endorobotic platforms with stable camera...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Ilker Ozgur, Emre Gorgun Source Type: research

Surgical Principles of Rectal Cancer
This article reviews the oncological principles of rectal cancer surgery, beginning with an overview of the pertinent rectal and pelvic anatomy, followed by a discussion of the historical evolution in surgical management. Evidence supporting current practices with respect to proximal, distal, and circumferential margins are reviewed. Finally, operative approaches to restorative proctectomies and abdominoperineal resections are highlighted. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Ebram Salama, Jessica Holland, Marylise Boutros Source Type: research

Targeted Therapy for Colorectal Cancer
Metastatic colorectal cancer (mCRC) is incurable in patients with unresectable disease. For most patients, the primary treatment is palliative systemic chemotherapy. Genomic profiling is used to detect specific genetic mutations that may offer selected patients a modest survival benefit with targeted therapy. Patients with mCRC with KRAS/NRAS/BRAF wild-type left-sided tumors may benefit from epidermal growth factor receptor (EGFR) inhibition with either cetuximab or panitumumab, in conjunction with chemotherapy. EGFR inhibitors can extend survival by 6 months compared with chemotherapy alone. The vascular endothelial growt...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Shinichiro Sakata, David W. Larson Source Type: research

Management of Synchronous Colorectal Cancer Metastases
The management of patients with metastatic colorectal cancer (CRC) has evolved significantly over the last decade owing to advances in aggressive multimodality chemotherapy options, targeted therapy, development of sophisticated operative techniques, and adjunct radiotherapy options. Patients with synchronous CRC require complex decision-making with multidisciplinary collaboration to develop individualized treatment strategies taking into account tumor biology and patients ’ individual goals and objectives. We will outline important considerations with regard to treatment options for patients with synchronous metastatic ...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Traci L. Hedrick, Victor M. Zaydfudim Source Type: research

Neoadjuvant Therapy for Rectal Cancer
The treatment of locally advanced rectal cancer is challenging and requires a multidisciplinary approach. Neoadjuvant treatment has improved local control by the combination of radiotherapy, surgery, and chemotherapy. However, neoadjuvant treatment has not yet been shown to improve overall survival and is associated with toxicities and late sequelae that impair the quality of life of patients. Currently, different types of neoadjuvant strategies have raised the question about which one is the optimal strategy for rectal cancer treatment. In this article, we explore the different neoadjuvant treatment regimens currently ava...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Felipe F. Quezada-Diaz, J. Joshua Smith Source Type: research

Management of Colorectal Cancer in Hereditary Syndromes
Approximately 5% of all colorectal cancers develop within a hereditary colorectal cancer syndrome. Patients and families with these syndromes have an increased risk of colorectal and extracolonic cancers that develop at an early age. Recognition and diagnosis of these conditions are crucial to management and risk reduction. Surgeons must be aware of the unique aspects of the timing and extent of surgery (both therapeutic and prophylactic) within these syndromes, particularly for the most common syndromes, Lynch syndrome and familial adenomatous polyposis. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Lisa A. Cunningham, Alessandra Gasior, Matthew F. Kalady Source Type: research

Colorectal Cancer
The preoperative assessment of patients with colorectal cancer (CRC) requires a multimodal approach, including endoscopic evaluation and clinical, radiographic, and biochemical assessment. In addition to providing a diagnosis, histologic review of biopsy specimens imparts valuable information about tumor grade and other important prognostic features that can help determine treatment. A thorough history and physical examination rounds out the initial evaluation and provides the surgeon and other treating physicians with vital additional information for detailed operative planning. Colon and rectal cancer, although closely r...
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Najjia N. Mahmoud Source Type: research

Colorectal Cancer
Although the incidence and mortality rates of colorectal cancer (CRC) are decreasing, the number of people over the age of 65 is expected to double by the year 2060. As CRC prevalence increases with age, the number of people diagnosed with CRC is expected to increase dramatically over the ensuing decades.1 Described as the “silver tsunami,” this trend will result in a substantial increase in the number of CRC patients, particularly those with accompanying comorbidities and complex surgical needs. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - March 9, 2022 Category: Surgery Authors: Traci L. Hedrick Tags: Preface Source Type: research

Healthcare Disparities and Colorectal Cancer
Health care disparities are defined as health differences between groups that are avoidable, unnecessary, and unjust. Racial disparities in colorectal cancer mortality, particularly for Black patients, are well-described. Disparities in preventative measures, early detection, effective treatment, and posttreatment services contribute to these differences. Underlying these issues are patient, provider, health care system, and policy-level factors that lead to these disparities. Multilevel interventions designed to address each level of care can provide an effective means to mitigate these disparities. (Source: Surgical Onco...
Source: Surgical Oncology Clinics of North America - March 8, 2022 Category: Surgery Authors: Robert H. Hollis, Daniel I. Chu Source Type: research

Complete Mesocolic Excision and Extent of Lymphadenectomy for the Treatment of Colon Cancer
Curative-intent surgical resection of colon cancer involves optimal approaches to the peri-tumoral tissue, the mesocolon, and the draining lymph nodes. The key corresponding concepts that will be discussed are complete mesocolic excision (CME), central vascular ligation (CVL) or D3 dissection, and circumferential resection margin (CRM). We aim to describe these techniques and delineate evidence surrounding their technical feasibility, pathologic detail, as well as long-term oncologic impact. CME with CVL and D3 dissection are overlapping concepts both emphasizing anatomy-based resection of tumor and regional lymph nodes th...
Source: Surgical Oncology Clinics of North America - March 5, 2022 Category: Surgery Authors: Tsuyoshi Konishi, Y. Nancy You Source Type: research

The Impact of Health Delivery Integration on Cancer Outcomes
Although integrated health care has largely been associated with increases in prices and static or decreased quality across many disease states, it has shown some successes in improving cancer care. However, its impact is largely equivocal, making consensus statements difficult. Critically, integration does not necessarily translate to clinical coordination, which might be the true driver behind the success of integrated health care delivery. Moving forward, it is important to establish payment models that support clinical care coordination. Shifting from a fragmented health system to a coordinated one may improve evidence...
Source: Surgical Oncology Clinics of North America - November 12, 2021 Category: Surgery Authors: Vishnukamal Golla, Deborah R. Kaye Source Type: research

Disparities and Determinants of Health in Surgical Oncology
Traditionally, Surgical Oncology Clinics of North America has focused on disease- or organ-specific cancer topics. In identifying topics for this year ’s issues, I believed that it was critical to address disparities and determinants of health within the larger field of surgical oncology itself. As such, this issue of the Surgical Oncology Clinics of North America is particularly important. Like all of you, I believe we are obligated as medical professionals to address disparities, and to use our collective voice to foster awareness around disparities within oncologic care. (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 12, 2021 Category: Surgery Authors: Timothy M. Pawlik Tags: Foreword Source Type: research

Disparities and Determinants of Health in Surgical Oncology
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA (Source: Surgical Oncology Clinics of North America)
Source: Surgical Oncology Clinics of North America - November 12, 2021 Category: Surgery Authors: Oluwadamilola M. Fayanju Source Type: research

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Source: Surgical Oncology Clinics of North America - November 12, 2021 Category: Surgery Source Type: research