Front Cover
Cover Image © Wiley-VCH GmbH. The image is part of a figure in the article DOI:10.1002/pmic.201900203 by Lei Li, Yong Jiang et al. (Source: Proteomics)
Source: Proteomics - November 21, 2023 Category: Biochemistry Tags: FRONT COVER Source Type: research
Contents: Proteomics 21 –22'23
(Source: Proteomics)
Source: Proteomics - November 21, 2023 Category: Biochemistry Tags: CONTENTS Source Type: research
Editorial Board: Proteomics 21 –22'23
(Source: Proteomics)
Source: Proteomics - November 21, 2023 Category: Biochemistry Tags: EDITORIAL BOARD Source Type: research
State of the art in data integration and network biology (special issue)
(Source: Proteomics)
Source: Proteomics - November 21, 2023 Category: Biochemistry Authors: Andrew Emili Tags: EDITORIAL Source Type: research
Elucidating the dynamic remodelling of Escherichia coli interactome in different growth conditions using multiplex co ‐fractionation MS (mCF‐MS)
AbstractMost proteins function by forming complexes within a dynamic interconnected network that underlies various biological mechanisms. To systematically investigate such interactomes, high-throughput techniques, including CF-MS, have been developed to capture, identify, and quantify protein-protein interactions (PPIs) on a large scale. Compared to other techniques, CF-MS allows the global identification and quantification of native protein complexes in one setting, without genetic manipulation. Furthermore, quantitative CF-MS can potentially elucidate the distribution of a protein in multiple co-elution features, inform...
Source: Proteomics - November 21, 2023 Category: Biochemistry Authors: Teck Yew Low Tags: COMMENTARY Source Type: research
Capillary zone electrophoresis ‐high field asymmetric ion mobility spectrometry‐tandem mass spectrometry for top‐down characterization of histone proteoforms
AbstractCharacterization of histone proteoforms with various post-translational modifications (PTMs) is critical for a better understanding of functions of histone proteoforms in epigenetic control of gene expression. Mass spectrometry (MS)-based top-down proteomics (TDP) is a valuable approach for delineating histone proteoforms because it can provide us with a bird's-eye view of histone proteoforms carrying diverse combinations of PTMs. Here, we present the first example of coupling capillary zone electrophoresis (CZE), ion mobility spectrometry (IMS), and MS for online multi-dimensional separations of histone proteoform...
Source: Proteomics - November 15, 2023 Category: Biochemistry Authors: Qianyi Wang,
Fei Fang,
Qianjie Wang,
Liangliang Sun Tags: RESEARCH ARTICLE Source Type: research
People with obesity exhibit losses in muscle proteostasis that are partly improved by exercise training
AbstractThis pilot experiment examines if a loss in muscle proteostasis occurs in people with obesity and whether endurance exercise positively influences either the abundance profile or turnover rate of proteins in this population. Men with (n = 3) or without (n = 4) obesity were recruited and underwent a 14-d measurement protocol of daily deuterium oxide (D2O) consumption and serial biopsies of vastus lateralis muscle. Men with obesity then completed 10-weeks of high-intensity interval training (HIIT), encompassing 3 sessions per week of cycle ergometer exercise with 1 min intervals at 100% maximum aerobic power in...
Source: Proteomics - November 15, 2023 Category: Biochemistry Authors: Kanchana Srisawat,
Connor A. Stead,
Katie Hesketh,
Mark Pogson,
Juliette A. Strauss,
Matt Cocks,
Ivo Siekmann,
Stuart M. Phillips,
Paulo J. Lisboa,
Sam Shepherd,
Jatin G. Burniston Tags: RESEARCH ARTICLE Source Type: research
Eye proteome of Drosophila melanogaster
AbstractDrosophila melanogaster is a popular model organism to elucidate the molecular mechanisms that underlie the structure and function of the eye as well as the causes of retinopathies, aging, light-induced damage, or dietary deficiencies. Large-scale screens have isolated genes whose mutation causes morphological and functional ocular defects, which led to the discovery of key components of the phototransduction cascade. However, the proteome of theDrosophila eye is poorly characterized. Here, we used GeLC-MS/MS to quantify 3516 proteins, including the absolute (molar) quantities of 43 proteins in the eye of adult mal...
Source: Proteomics - November 15, 2023 Category: Biochemistry Authors: Mukesh Kumar,
Canan Has,
Khanh Lam ‐Kamath,
Sophie Ayciriex,
Deepshe Dewett,
Mhamed Bashir,
Clara Poupault,
Kai Schuhmann,
Henrik Thomas,
Oskar Knittelfelder,
Bharath Kumar Raghuraman,
Robert Ahrends,
Jens Rister,
Andrej Shevchenko Tags: DATASET BRIEF Source Type: research
Decoding the molecular interplay in the central dogma: An overview of mass spectrometry ‐based methods to investigate protein‐metabolite interactions
This article is protected by copyright. All rights reserved (Source: Proteomics)
Source: Proteomics - November 13, 2023 Category: Biochemistry Authors: Paolo Stincone,
Amira Naimi,
Anthony J. Saviola,
Raphael Reher,
Daniel Petras Tags: REVIEW Source Type: research
Extracellular vesicles from non ‐neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells
AbstractSmall cell lung cancer (SCLC) tumors are made up of distinct cell subpopulations, including neuroendocrine (NE) and non-neuroendocrine (non-NE) cells. While secreted factors from non-NE SCLC cells have been shown to support the growth of the NE cells, the underlying molecular factors are not well understood. Here, we show that exosome-type small extracellular vesicles (SEVs) secreted from non-NE SCLC cells promote adhesion and survival of NE SCLC cells. Proteomic analysis of purified SEVs revealed that extracellular matrix (ECM) proteins and integrins are highly enriched in SEVs of non-NE cells whereas nucleic acid...
Source: Proteomics - November 6, 2023 Category: Biochemistry Authors: Lizandra Jimenez,
Victor Stolzenbach,
Patricia M. M. Ozawa,
Marisol Ramirez ‐Solano,
Qi Liu,
Julien Sage,
Alissa M. Weaver Tags: RESEARCH ARTICLE Source Type: research
