Edi(torial) 2024: action plan for change and new initiatives
Platelets. 2024 Dec;35(1):2315713. doi: 10.1080/09537104.2024.2315713. Epub 2024 Feb 14.NO ABSTRACTPMID:38353273 | DOI:10.1080/09537104.2024.2315713 (Source: Platelets)
Source: Platelets - February 14, 2024 Category: Hematology Authors: Kirk A Taylor Source Type: research
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics
Platelets. 2024 Dec;35(1):2313359. doi: 10.1080/09537104.2024.2313359. Epub 2024 Feb 14.ABSTRACTCyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been extensively studied. However, its role in regulating the biomechanical properties of platelets has not yet been addressed and remains unknown. We therefore investigated the stiffness of living platelets after treatment with the NO-GC stimulator riociguat or the NO-GC activator cinaciguat using scanning ion conductance microscopy (SICM). Stimulation of human and murine pla...
Source: Platelets - February 14, 2024 Category: Hematology Authors: Aylin Balmes Johanna G Rodr íguez Jan Seifert Daniel Pinto-Quintero Akif A Khawaja Marta Boffito Maike Frye Andreas Friebe Michael Emerson Francesca Seta Robert Feil Susanne Feil Tilman E Sch äffer Source Type: research
Edi(torial) 2024: action plan for change and new initiatives
Platelets. 2024 Dec;35(1):2315713. doi: 10.1080/09537104.2024.2315713. Epub 2024 Feb 14.NO ABSTRACTPMID:38353273 | DOI:10.1080/09537104.2024.2315713 (Source: Platelets)
Source: Platelets - February 14, 2024 Category: Hematology Authors: Kirk A Taylor Source Type: research
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics
Platelets. 2024 Dec;35(1):2313359. doi: 10.1080/09537104.2024.2313359. Epub 2024 Feb 14.ABSTRACTCyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been extensively studied. However, its role in regulating the biomechanical properties of platelets has not yet been addressed and remains unknown. We therefore investigated the stiffness of living platelets after treatment with the NO-GC stimulator riociguat or the NO-GC activator cinaciguat using scanning ion conductance microscopy (SICM). Stimulation of human and murine pla...
Source: Platelets - February 14, 2024 Category: Hematology Authors: Aylin Balmes Johanna G Rodr íguez Jan Seifert Daniel Pinto-Quintero Akif A Khawaja Marta Boffito Maike Frye Andreas Friebe Michael Emerson Francesca Seta Robert Feil Susanne Feil Tilman E Sch äffer Source Type: research
Edi(torial) 2024: action plan for change and new initiatives
Platelets. 2024 Dec;35(1):2315713. doi: 10.1080/09537104.2024.2315713. Epub 2024 Feb 14.NO ABSTRACTPMID:38353273 | DOI:10.1080/09537104.2024.2315713 (Source: Platelets)
Source: Platelets - February 14, 2024 Category: Hematology Authors: Kirk A Taylor Source Type: research
Role of the NO-GC/cGMP signaling pathway in platelet biomechanics
Platelets. 2024 Dec;35(1):2313359. doi: 10.1080/09537104.2024.2313359. Epub 2024 Feb 14.ABSTRACTCyclic guanosine monophosphate (cGMP) is a second messenger produced by the NO-sensitive guanylyl cyclase (NO-GC). The NO-GC/cGMP pathway in platelets has been extensively studied. However, its role in regulating the biomechanical properties of platelets has not yet been addressed and remains unknown. We therefore investigated the stiffness of living platelets after treatment with the NO-GC stimulator riociguat or the NO-GC activator cinaciguat using scanning ion conductance microscopy (SICM). Stimulation of human and murine pla...
Source: Platelets - February 14, 2024 Category: Hematology Authors: Aylin Balmes Johanna G Rodr íguez Jan Seifert Daniel Pinto-Quintero Akif A Khawaja Marta Boffito Maike Frye Andreas Friebe Michael Emerson Francesca Seta Robert Feil Susanne Feil Tilman E Sch äffer Source Type: research
Edi(torial) 2024: action plan for change and new initiatives
Platelets. 2024 Dec;35(1):2315713. doi: 10.1080/09537104.2024.2315713. Epub 2024 Feb 14.NO ABSTRACTPMID:38353273 | DOI:10.1080/09537104.2024.2315713 (Source: Platelets)
Source: Platelets - February 14, 2024 Category: Hematology Authors: Kirk A Taylor Source Type: research
Antiplatelet effects of the CEACAM1-derived peptide QDTT
In this study, screening against collagen-induced platelet aggregation was performed to identify functional CEACAM1 extracellular domain fragments. CEACAM1 fragments, including Ala-substituted peptides, were synthesized. Platelet assays were conducted on healthy donor samples for aggregation, cytotoxicity, adhesion, spreading, and secretion. Mice were used for tail bleeding and FeCl3-induced thrombosis experiments. Clot retraction was assessed using platelet-rich plasma. Extracellular segments of CEACAM1 and A1 domain-derived peptide QDTT were identified, while N, A2, and B domains showed no involvement. QDTT inhibited pla...
Source: Platelets - February 12, 2024 Category: Hematology Authors: Yujia Ye Min Leng Shengjie Chai Lihong Yang Longcheng Ren Wen Wan Huawei Wang Longjun Li Chaozhong Li Zhaohui Meng Source Type: research
Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics
Platelets. 2024 Dec;35(1):2306983. doi: 10.1080/09537104.2024.2306983. Epub 2024 Feb 5.ABSTRACTAlthough there have been tremendous improvements in the production and storage of platelets, platelet transfusion refractoriness (PTR) remains a serious clinical issue that may lead to various severe adverse events. The burden of supplying platelets is worsened by rising market demand and limited donor pools of compatible platelets. Antibodies against platelet antigens are known to activate platelets through FcγR-dependent or complement-activated channels, thereby rapidly eliminating foreign platelets. Recently, other mechanisms...
Source: Platelets - February 5, 2024 Category: Hematology Authors: Xiaoyu Chen Yuhong Zhao Yan Lv Jue Xie Source Type: research
Transcription factor 3 is dysregulated in megakaryocytes in myelofibrosis
Platelets. 2024 Dec;35(1):2304173. doi: 10.1080/09537104.2024.2304173. Epub 2024 Feb 1.ABSTRACTTranscription factor 3 (TCF3) is a DNA transcription factor that modulates megakaryocyte development. Although abnormal TCF3 expression has been identified in a range of hematological malignancies, to date, it has not been investigated in myelofibrosis (MF). MF is a Philadelphia-negative myeloproliferative neoplasm (MPN) that can arise de novo or progress from essential thrombocythemia [ET] and polycythemia vera [PV] and where dysfunctional megakaryocytes have a role in driving the fibrotic progression. We aimed to examine whethe...
Source: Platelets - February 2, 2024 Category: Hematology Authors: Ryan J Collinson Lynne Wilson Darren Boey Zi Yun Ng Bob Mirzai Hun S Chuah Rebecca Howman Carolyn S Grove Jacques A J Malherbe Michael F Leahy Matthew D Linden Kathryn A Fuller Wendy N Erber Belinda B Guo Source Type: research
The efficacy of platelet rich plasma on women with poor ovarian response: a systematic review and meta-analysis
CONCLUSIONS: Among the studies evaluated in this review, PRP showed promising results in poor responder. Further research is required to clarify the potential role of PRP in female reproductive health.PMID:38214306 | DOI:10.1080/09537104.2023.2292612 (Source: Platelets)
Source: Platelets - January 12, 2024 Category: Hematology Authors: Lingling Wu Fenfang Su Peixin Luo Qingqing Dong Mengni Ma Guangyong Ye Source Type: research
Gravity sedimentation reveals functionally and morphologically different platelets in human blood
Platelets. 2024 Dec;35(1):2298341. doi: 10.1080/09537104.2023.2298341. Epub 2024 Jan 8.ABSTRACTIn contrast to red blood cells, platelets float rather than sediment when a column of blood is placed in the gravitational field. By the analogy of erythrocyte sedimentation (ESR), it can be expressed with the platelet antisedimentation rate (PAR), which quantitates the difference in platelet count between the upper and lower halves of the blood column after 1 h of 1 g sedimentation. Venous blood samples from 21 healthy subjects were analyzed for PAR. After a 1-h sedimentation, the upper and lower fractions of blood samples were ...
Source: Platelets - January 8, 2024 Category: Hematology Authors: Erzs ébet Ezer Diana Schrick Margit T őkés-Füzesi Istv án Papp Barbara R éger Abig él Molnár Hajnalka Ábrahám Akos Koller Jol án Hársfalvi Mikl ós Kellermayer Tiham ér Molnár Source Type: research
Utility of VerifyNow to assess the immediate pharmacodynamic response of chewed and swallowed aspirin: comparison with aggregometry
Platelets. 2024 Dec;35(1):2298352. doi: 10.1080/09537104.2023.2298352. Epub 2024 Jan 3.ABSTRACTVerifyNow (VN) test is a less laborious method to assess pharmacodynamics (PD) compared to light transmittance aggregometry (LTA). VN assay has not been used to study the immediate PD effects of acetylsalicylic acid (ASA). Ten healthy volunteers were randomly assigned to a single 162 or 650 mg dose of chewed and swallowed ASA. Pharmacodynamic and pharmacokinetic measurements were performed at baseline and serially up to 60 min after ASA administration. Onset by VN was 20 ± 7 min with 162 mg and 13 ± 7 min with 650 mg ASA (p = ....
Source: Platelets - January 3, 2024 Category: Hematology Authors: Kevin P Bliden Parshotam Kundan Danielle Kraft Rueshil Parekh Sahib Singh Aravind D Babu Anika P Shah Udaya S Tantry Paul A Gurbel Source Type: research
