Anti-GPIb/IX autoantibodies are associated with poor response to dexamethasone combined with rituximab therapy in primary immune thrombocytopenia patients
Platelets. 2023 Dec;34(1):2258988. doi: 10.1080/09537104.2023.2258988. Epub 2023 Sep 18.ABSTRACTThis retrospective study aimed to evaluate whether anti-glycoproteins (GPs) autoantibodies can be used as predictors of response to high-dose dexamethasone combined with rituximab (DXM-RTX) in the treatment of primary immune thrombocytopenia (ITP) patients. One-hundred twenty-six ITP patients were included and retrospectively analyzed, 66.7% of anti-GPIb/IX and 65.9% of anti-GPIIb/IIIa autoantibodies. Results showed that overall response (OR) and complete response (CR) rates of patients without anti-GPIb/IX autoantibodies to DXM...
Source: Platelets - September 18, 2023 Category: Hematology Authors: Bingjie Ding Liu Liu Mengjuan Li Xuewen Song Yuanyuan Zhang Ao Xia Jingyuan Liu Hu Zhou Source Type: research
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients
In conclusion, our study highlights the role of elevated platelet α-tubulin K40 acetylation as a marker of platelet inhibition in response to DAPT.Clinical trial registration: https://clinicaltrials.gov - NCT03034148.PMID:37700239 | DOI:10.1080/09537104.2023.2250002 (Source: Platelets)
Source: Platelets - September 12, 2023 Category: Hematology Authors: Valentine Robaux Shakeel Kautbally Audrey Ginion M élanie Dechamps Sibille Lejeune Nassiba Menghoum Luc Bertrand Anne-Catherine Pouleur Sandrine Horman Christophe Beauloye Source Type: research
A novel, quantitative clot retraction assay to evaluate platelet function
Platelets. 2023 Dec;34(1):2254403. doi: 10.1080/09537104.2023.2254403.ABSTRACTBlood platelets are crucial to prevent excessive bleeding following injury to blood vessels. Platelets are crucial for the formation of clots and for clot strength. Platelet activation involves aggregation, attachment to fibrin and clot retraction. Most assays that address platelet function measure platelet aggregation, not clot retraction. Here, we describe a 96-well-based clot retraction assay that requires a relatively short runtime and small sample volume. The assay involves continuous optical density monitoring of platelet-rich plasma that i...
Source: Platelets - September 12, 2023 Category: Hematology Authors: Wayne T Muraoka Prajeeda M Nair Daniel N Darlington Xiaowu Wu James A Bynum Andrew P Cap Source Type: research
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients
In conclusion, our study highlights the role of elevated platelet α-tubulin K40 acetylation as a marker of platelet inhibition in response to DAPT.Clinical trial registration: https://clinicaltrials.gov - NCT03034148.PMID:37700239 | DOI:10.1080/09537104.2023.2250002 (Source: Platelets)
Source: Platelets - September 12, 2023 Category: Hematology Authors: Valentine Robaux Shakeel Kautbally Audrey Ginion M élanie Dechamps Sibille Lejeune Nassiba Menghoum Luc Bertrand Anne-Catherine Pouleur Sandrine Horman Christophe Beauloye Source Type: research
A novel, quantitative clot retraction assay to evaluate platelet function
Platelets. 2023 Dec;34(1):2254403. doi: 10.1080/09537104.2023.2254403.ABSTRACTBlood platelets are crucial to prevent excessive bleeding following injury to blood vessels. Platelets are crucial for the formation of clots and for clot strength. Platelet activation involves aggregation, attachment to fibrin and clot retraction. Most assays that address platelet function measure platelet aggregation, not clot retraction. Here, we describe a 96-well-based clot retraction assay that requires a relatively short runtime and small sample volume. The assay involves continuous optical density monitoring of platelet-rich plasma that i...
Source: Platelets - September 12, 2023 Category: Hematology Authors: Wayne T Muraoka Prajeeda M Nair Daniel N Darlington Xiaowu Wu James A Bynum Andrew P Cap Source Type: research
Dual antiplatelet therapy is associated with high α-tubulin acetylation in circulating platelets from coronary artery disease patients
In conclusion, our study highlights the role of elevated platelet α-tubulin K40 acetylation as a marker of platelet inhibition in response to DAPT.Clinical trial registration: https://clinicaltrials.gov - NCT03034148.PMID:37700239 | DOI:10.1080/09537104.2023.2250002 (Source: Platelets)
Source: Platelets - September 12, 2023 Category: Hematology Authors: Valentine Robaux Shakeel Kautbally Audrey Ginion M élanie Dechamps Sibille Lejeune Nassiba Menghoum Luc Bertrand Anne-Catherine Pouleur Sandrine Horman Christophe Beauloye Source Type: research
A novel, quantitative clot retraction assay to evaluate platelet function
Platelets. 2023 Dec;34(1):2254403. doi: 10.1080/09537104.2023.2254403.ABSTRACTBlood platelets are crucial to prevent excessive bleeding following injury to blood vessels. Platelets are crucial for the formation of clots and for clot strength. Platelet activation involves aggregation, attachment to fibrin and clot retraction. Most assays that address platelet function measure platelet aggregation, not clot retraction. Here, we describe a 96-well-based clot retraction assay that requires a relatively short runtime and small sample volume. The assay involves continuous optical density monitoring of platelet-rich plasma that i...
Source: Platelets - September 12, 2023 Category: Hematology Authors: Wayne T Muraoka Prajeeda M Nair Daniel N Darlington Xiaowu Wu James A Bynum Andrew P Cap Source Type: research
