Relationship between endotoxin core, staphylococcal and varicella antibody levels and outcome following aortic valve replacement surgery: a prospective observational study
ConclusionsThis study again suggests the inverse relationship between endotoxin core antibody levels and outcome following aortic valve surgery as well as suggesting a similar relationship with antibodies to staphylococcus. There is no such relationship for antibody levels against an organism not providing a peri-operative threat. Understanding this relationship may enable therapeutic manipulation of immune status, re-evaluation of risk and further investigation of the low immune state.Trial registrationThe patients in this study are a sub-group of the RELIEF AS study.ClinicalTrials.gov identifierNCT02174471. (Source: Perioperative Medicine)
Source: Perioperative Medicine - September 20, 2018 Category: Surgery Source Type: research
Comparison of dextran and albumin on blood coagulation in patients undergoing major gynaecological surgery
ConclusionsStandard plasma-based coagulation tests, platelet count and whole blood viscoelastic clot structure are affected by 6% dextran-70 to a greater extent than by 5% albumin, but platelet aggregation is not. Future studies should use more advanced haemodynamic monitoring to assess isovolemic plasma volume expansion with dextran and whether this affects haemostasis to a lesser degree. (Source: Perioperative Medicine)
Source: Perioperative Medicine - September 6, 2018 Category: Surgery Source Type: research
