Fibroblast activation protein- α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target
Conclusion: In the crosstalk between tumor cells and TME, CAF play a key role in carcinogenesis and metastatic spread. Expression of FAP was detectable in the majority of CRC but nearly absent in precursor lesions and non-neoplastic, non-inflammatory tissue. This finding indicates that FAP has the potential to emerge as a target for new diagnostic and therapeutic concepts in CRC. Additionally, the association between FAP expression and other immunohistochemical parameters displays the interaction between different components of the TME and demands further investigation.PMID:37614665 | PMC:PMC10442481 | DOI:10.3389/pore.202...
Source: Pathology Oncology Research - August 24, 2023 Category: Pathology Authors: K Greimelmaier N Klopp E Mairinger M Wessolly S Borchert J Steinborn K W Schmid J Wohlschlaeger F D Mairinger Source Type: research
Fibroblast activation protein- α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target
Conclusion: In the crosstalk between tumor cells and TME, CAF play a key role in carcinogenesis and metastatic spread. Expression of FAP was detectable in the majority of CRC but nearly absent in precursor lesions and non-neoplastic, non-inflammatory tissue. This finding indicates that FAP has the potential to emerge as a target for new diagnostic and therapeutic concepts in CRC. Additionally, the association between FAP expression and other immunohistochemical parameters displays the interaction between different components of the TME and demands further investigation.PMID:37614665 | PMC:PMC10442481 | DOI:10.3389/pore.202...
Source: Pathology Oncology Research - August 24, 2023 Category: Pathology Authors: K Greimelmaier N Klopp E Mairinger M Wessolly S Borchert J Steinborn K W Schmid J Wohlschlaeger F D Mairinger Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation
Conclusion: The WF-OCT images captured in this study displayed the key features of the most common human tissue types encountered in surgical oncology with utility comparable to histology, confirming the utility of an FDA-cleared imaging platform. With further study, WF-OCT may have the potential to bridge the gap between the immediate information needs of the operating room and the longer timeline inherent to histology workflow.PMID:37521364 | PMC:PMC10374948 | DOI:10.3389/pore.2023.1611167 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - July 31, 2023 Category: Pathology Authors: Beryl Rabindran Adriana D Corben Source Type: research
