Fibroblast activation protein- α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target

Conclusion: In the crosstalk between tumor cells and TME, CAF play a key role in carcinogenesis and metastatic spread. Expression of FAP was detectable in the majority of CRC but nearly absent in precursor lesions and non-neoplastic, non-inflammatory tissue. This finding indicates that FAP has the potential to emerge as a target for new diagnostic and therapeutic concepts in CRC. Additionally, the association between FAP expression and other immunohistochemical parameters displays the interaction between different components of the TME and demands further investigation.PMID:37614665 | PMC:PMC10442481 | DOI:10.3389/pore.2023.1611163
Source: Pathology Oncology Research - Category: Pathology Authors: Source Type: research