Patient delay and its clinical significance among head and neck cancer patients in Hungary
Discussion: Compared to data from different countries, the delay of Hungarian patients with head and neck cancer is significantly longer, which may contribute to the high mortality in Hungary. Screening and patient education in high-risk groups could contribute to earlier diagnosis and thus improve prognosis.PMID:37674645 | PMC:PMC10477355 | DOI:10.3389/pore.2023.1611206 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 7, 2023 Category: Pathology Authors: Korn él Dános Ang éla Horváth Judit Hal ász L ászló Tamás G ábor Polony Source Type: research
Patient delay and its clinical significance among head and neck cancer patients in Hungary
Discussion: Compared to data from different countries, the delay of Hungarian patients with head and neck cancer is significantly longer, which may contribute to the high mortality in Hungary. Screening and patient education in high-risk groups could contribute to earlier diagnosis and thus improve prognosis.PMID:37674645 | PMC:PMC10477355 | DOI:10.3389/pore.2023.1611206 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - September 7, 2023 Category: Pathology Authors: Korn él Dános Ang éla Horváth Judit Hal ász L ászló Tamás G ábor Polony Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Obesity as a risk factor for multiple myeloma: insight on the role of adipokines
Pathol Oncol Res. 2023 Aug 10;29:1611338. doi: 10.3389/pore.2023.1611338. eCollection 2023.ABSTRACTMultiple myeloma (MM) is a hematologic disorder characterized by the accumulation of malignant plasma cells in the bone marrow. Genetic and environmental factors are contributed to the etiology of MM. Notably, studies have shown that obesity increases the risk of MM and worsens outcomes for MM patients. Adipokines play an important role in mediating the close association between MM and metabolic derangements. In this review, we summarize the epidemiologic studies to show that the risk of MM is increased in obese. Accumulating...
Source: Pathology Oncology Research - August 28, 2023 Category: Pathology Authors: Wenting Tie Tao Ma Zhigang Yi Jia Liu Yanhong Li Jun Bai Lijuan Li Liansheng Zhang Source Type: research
Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma
Conclusion: This is the first study to comprehensively describe the expression of different CLDNs in lung ACC and MEC. Overexpression of certain CLDNs may pave the way for targeted anti-claudin therapy in these rare histological subtypes of lung cancer.PMID:37621953 | PMC:PMC10444951 | DOI:10.3389/pore.2023.1611328 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 25, 2023 Category: Pathology Authors: Marton Gyulai Tunde Harko Katalin Fabian Luca Karsko Laszlo Agocs Balazs Szigeti Janos Fillinger Zoltan Szallasi Orsolya Pipek Judit Moldvay Source Type: research
Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma
Conclusion: This is the first study to comprehensively describe the expression of different CLDNs in lung ACC and MEC. Overexpression of certain CLDNs may pave the way for targeted anti-claudin therapy in these rare histological subtypes of lung cancer.PMID:37621953 | PMC:PMC10444951 | DOI:10.3389/pore.2023.1611328 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 25, 2023 Category: Pathology Authors: Marton Gyulai Tunde Harko Katalin Fabian Luca Karsko Laszlo Agocs Balazs Szigeti Janos Fillinger Zoltan Szallasi Orsolya Pipek Judit Moldvay Source Type: research
Claudin expression in pulmonary adenoid cystic carcinoma and mucoepidermoid carcinoma
Conclusion: This is the first study to comprehensively describe the expression of different CLDNs in lung ACC and MEC. Overexpression of certain CLDNs may pave the way for targeted anti-claudin therapy in these rare histological subtypes of lung cancer.PMID:37621953 | PMC:PMC10444951 | DOI:10.3389/pore.2023.1611328 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - August 25, 2023 Category: Pathology Authors: Marton Gyulai Tunde Harko Katalin Fabian Luca Karsko Laszlo Agocs Balazs Szigeti Janos Fillinger Zoltan Szallasi Orsolya Pipek Judit Moldvay Source Type: research
Fibroblast activation protein- α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target
Conclusion: In the crosstalk between tumor cells and TME, CAF play a key role in carcinogenesis and metastatic spread. Expression of FAP was detectable in the majority of CRC but nearly absent in precursor lesions and non-neoplastic, non-inflammatory tissue. This finding indicates that FAP has the potential to emerge as a target for new diagnostic and therapeutic concepts in CRC. Additionally, the association between FAP expression and other immunohistochemical parameters displays the interaction between different components of the TME and demands further investigation.PMID:37614665 | PMC:PMC10442481 | DOI:10.3389/pore.202...
Source: Pathology Oncology Research - August 24, 2023 Category: Pathology Authors: K Greimelmaier N Klopp E Mairinger M Wessolly S Borchert J Steinborn K W Schmid J Wohlschlaeger F D Mairinger Source Type: research
Fibroblast activation protein- α expression in fibroblasts is common in the tumor microenvironment of colorectal cancer and may serve as a therapeutic target
Conclusion: In the crosstalk between tumor cells and TME, CAF play a key role in carcinogenesis and metastatic spread. Expression of FAP was detectable in the majority of CRC but nearly absent in precursor lesions and non-neoplastic, non-inflammatory tissue. This finding indicates that FAP has the potential to emerge as a target for new diagnostic and therapeutic concepts in CRC. Additionally, the association between FAP expression and other immunohistochemical parameters displays the interaction between different components of the TME and demands further investigation.PMID:37614665 | PMC:PMC10442481 | DOI:10.3389/pore.202...
Source: Pathology Oncology Research - August 24, 2023 Category: Pathology Authors: K Greimelmaier N Klopp E Mairinger M Wessolly S Borchert J Steinborn K W Schmid J Wohlschlaeger F D Mairinger Source Type: research
Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy
Pathol Oncol Res. 2023 Aug 2;29:1611300. doi: 10.3389/pore.2023.1611300. eCollection 2023.ABSTRACTRecent studies have highlighted a possible correlation between microbiota composition and the pathogenesis of various oncological diseases. Also, many bacterial groups are now directly or indirectly associated with the capability of stimulating or inhibiting carcinogenic pathways. However, little is known about the importance and impact of microbiota patterns related to the efficacy and toxicity of cancer treatments. We have recently begun to understand how oncological therapies and the microbiota are closely interconnected an...
Source: Pathology Oncology Research - August 18, 2023 Category: Pathology Authors: Massimiliano Cazzaniga Giordano Bruno Zonzini Francesco Di Pierro Chiara Maria Palazzi Marco Cardinali Alexander Bertuccioli Source Type: research
