Copyright
ELSEVIER (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 20, 2020 Category: Neurology Source Type: research
Contributors
RANDOLPH W. EVANS, MD (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 20, 2020 Category: Neurology Source Type: research
Contents
Jos é Biller (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 20, 2020 Category: Neurology Source Type: research
Forthcoming Issues
Neurologic Emergencies (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 20, 2020 Category: Neurology Source Type: research
Update on Calcitonin Gene-Related Peptide Antagonism in the Treatment of Migraine
The discovery of calcitonin gene-related peptide (CGRP) and its role in migraine has promoted a new era in migraine treatment: CGRP antagonism. Two classes of medications are currently available: small molecules targeting the CGRP receptor and monoclonal antibodies targeting the CGRP receptor or CGRP ligand. The revolution of these medications is represented by blurring the borders between acute and preventive treatments, episodic and chronic migraine, na ïve and refractory patients and even between migraine and other headache disorders. (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Edoardo Caronna, Amaal J. Starling Source Type: research
Advances in the Treatment of Multiple Sclerosis
This article reviews data on available treatments along with a discussion of future treatment targets under investigation. (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Carolyn Goldschmidt, Marisa P. McGinley Source Type: research
Advances in the Treatment of Neuromyelitis Optica Spectrum Disorder
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, relapsing-remitting neuroinflammatory disorder of the central nervous system. Advances in the understanding of NMOSD pathogenesis and identification of the NMO-specific pathogenic anti-AQP4 autoantibody have led to the development of highly effective disease-modifying strategies. Five placebo-controlled, randomized trials for NMOSD have been successfully completed as of 2020. These trials support the efficacy of rituximab and tocilizumab and led to the FDA approval of eculizumab, satralizumab and inebilizumab for NMOSD. Our review provides an update on these evidenc...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Asya Izraelit Wallach, Matthew Tremblay, Ilya Kister Source Type: research
Advances and Future Directions of Neuromodulation in Neurologic Disorders
“Deep brain stimulation is a safe and effective therapy for the management of a variety of neurologic conditions with Food and Drug Administration or humanitarian exception approval for Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder. Advances in neurophysiology, neuroimagin g, and technology have driven increasing interest in the potential benefits of neurostimulation in other neuropsychiatric conditions including dementia, depression, pain, Tourette syndrome, and epilepsy, among others. New anatomic or combined targets are being investigated in these conditions to imp rove symptoms refractory to ...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Matthew R. Burns, Shannon Y. Chiu, Bhavana Patel, Sotiris G. Mitropanopoulos, Joshua K. Wong, Adolfo Ramirez-Zamora Source Type: research
Advances in the Management of Small Fiber Neuropathy
Small fiber neuropathy (SFN) is a prevalent neurologic syndrome. Testing methods have emerged in recent years to better diagnose it, including autonomic tests and skin punch biopsy. SFN can present in a non –length-dependent fashion and can be mistaken for syndromes such as fibromyalgia and complex regional pain syndrome. SFN is caused by a variety of metabolic, infectious, genetic, and inflammatory diseases. Recently treatments have emerged for TTR amyloid neuropathy and Fabry disease, and novel bio markers have been found both in genetic and inflammatory SFN syndromes. Ongoing trials attempt to establish the efficacy o...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Lawrence A. Zeidman Source Type: research
Update in the Management of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome
This article focuses on advances in management of autoimmune MG and LEMS. (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Cynthia Bodkin, Robert M. Pascuzzi Source Type: research
Update in the Management of Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension is a syndrome of increased intracranial pressure of unknown cause that most often occurs in women of childbearing age. Most patients are overweight or obese with a history of recent weight gain. Following a brief review of the symptoms and signs, we discuss the approach to assessment and monitoring of this condition. We then present a practical approach to treatment. Because patients frequently struggle with weight loss and can also have refractory headaches and coexisting psychosocial issues, we emphasize the importance of a multidisciplinary approach to the management of this common c...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Matthew J. Thurtell, Aki Kawasaki Source Type: research
What is New in Neuro-oncology?
Neuro-oncology is a rapidly developing field. A continuous evolution in the understanding of the molecular underpinnings of central nervous system tumors has helped reconfigure the classification of brain tumors. More importantly, it has laid the path forward for the development and investigation of new therapeutics. The authors discuss the classification of brain tumors and novel therapies in brain tumors as well as promising treatments underway. (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Jigisha P. Thakkar, Vikram C. Prabhu, Katherine B. Peters, Rimas V. Lukas Source Type: research
Advances in the Surgical Management of Epilepsy
This article discusses the advances in surg ical treatment of DRE in adults with focal seizures. (Source: Neurologic Clinics)
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Gregory D. Cascino, Benjamin H. Brinkmann Source Type: research
Treatment of Viral Encephalitis
Viral encephalitis is difficult to treat. Herpes simplex encephalitis has been successfully treated with acyclovir, but is still a cause for significant morbidity even with that treatment. A rare form of autoimmune encephalitis related to NMDA receptor antibody after infection by herpes simplex can be treated with corticosteroid therapy. Arthropod-borne encephalitides, such as West Nile virus encephalitis and Eastern equine encephalitis, are primarily treated with supportive measures. Attempts have been made to use immunoglobulin therapy with limited effects. Progressive multifocal leukoencephalopathy has been treated with...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Allen J. Aksamit Source Type: research
Cannabinoids in Neurologic Illnesses
Marijuana has been used to treat medical disease since well before the 1800s. Recently, increased use of cannabinoids, the chemical components of marijuana, have been seen to treat neurologic illness in children and adults. Unfortunately, data are lacking in treating most neurologic illnesses except in the field of epilepsy and pain from spasticity in multiple sclerosis. Therefore, formal conclusions about the potential efficacy, benefit, and adverse effects for most marijuana based products cannot be made at this time. Further research using gold standard scientific methodology should be performed to help address potentia...
Source: Neurologic Clinics - November 7, 2020 Category: Neurology Authors: Anup D. Patel Source Type: research
