Immunohistochemical Glomerular Expression of Phospholipase A2 Receptor in Primary and Secondary Membranous Nephropathy: A Retrospective Study in an Indian Cohort with Clinicopathological Correlations
Conclusion: Anti-PLA2R IHC is a specific marker to distinguish primary MN from secondary MN.Nephron Extra 2017;7:1 –9 (Source: Nephron Extra)
Source: Nephron Extra - February 9, 2017 Category: Urology & Nephrology Source Type: research
Neutrophil Gelatinase-Associated Lipocalin, Fibroblast Growth Factor 23, and Soluble Klotho in Long-Term Kidney Donors
Background: The best treatment for end-stage renal disease (ESRD) is kidney transplantation. Twenty-seven percent of transplantations in Norway are from living donors. Recent studies have shown an increased risk of ESRD and increased mortality in donors. The aim of this study was to determine if the levels of the new biomarkers neutrophil gelatinase-associated lipocalin (NGAL), soluble Klotho (sKlotho), and fibroblast growth factor 23 (FGF23) are changed in kidney donors with normal kidney function defined as an estimated glomerular filtration rate (eGFR)>60 ml/min/1.73 m2 compared to patients with chronic kidney disease (...
Source: Nephron Extra - October 11, 2016 Category: Urology & Nephrology Source Type: research
New Insight into Atherosclerosis in Hemodialysis Patients: Overexpression of Scavenger Receptor and Macrophage Colony-Stimulating Factor Genes
Background: Scavenger receptors (SRs) play a pivotal role in atherogenesis. The mechanism of atherosclerosis, which is specific to hemodialysis (HD) patients, was studied on the basis of SR gene expressions.Methods: The gene expressions of SR type A (SR-A) and CD36 were studied in peripheral monocytes by real-time reverse transcription polymerase chain reaction. Data were compared between HD (n = 30) and age-matched control subjects (n = 10). Serum levels of macrophage colony-stimulating factor (M-CSF) were measured with enzyme-linked immunosorbent assay to test its role in SR expression. The statistical differences and as...
Source: Nephron Extra - August 26, 2016 Category: Urology & Nephrology Source Type: research
The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis
Background/Aim: We assess the impact of serum creatinine at baseline on complete remission rate and long-term outcome in severe lupus nephritis (SLN).Methods: A total of 86 adult patients with SLN [International Society of Nephrology/Renal Pathology Society (ISN/RPS) class IV lesions] were evaluated based on baseline serum creatinine levels ( ≤1.0, 1.01-1.5, 1.51-2.0, 2.01-3.0, and>3.0 mg/dl; n = 22, 23, 16, 12, and 13, respectively). The complete remission rates (serum creatinine level of ≤1.4 mg/dl and proteinuria of ≤0.33 g/day) and long-term outcomes (stable renal function, dialysis, and death) were compared. The...
Source: Nephron Extra - August 17, 2016 Category: Urology & Nephrology Source Type: research
Effects of Tumor Necrosis Factor- α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy
Conclusion: < /i > < /b > TNF- α potently stimulates podocytes to produce MCP-1, utilizing the TNFR2 receptor and the NF-#954;B and PI3K/Akt pathways. Both TNF-α and MCP-1 levels were increased in the urine of diabetic < i > db/db < /i > mice, correlating with the severity of diabetic albuminuria. < br / > Nephron Extra 2015;5:1-18 (Source: Nephron Extra)
Source: Nephron Extra - July 22, 2016 Category: Urology & Nephrology Source Type: research
Renal Effects and Carcinogenicity of Occupational Exposure to Uranium: A Meta-Analysis
Conclusion: Our hypothesis that a chronic uranium exposure is associated with an increased risk of cancer mortality or of kidney failure is refuted by clinical data. The decreased risk may result from better medical surveillance of uranium workers.Nephron Extra 2016;6:1-11 (Source: Nephron Extra)
Source: Nephron Extra - February 10, 2016 Category: Urology & Nephrology Source Type: research
A Higher Cardiothoracic Ratio Is Associated with 2-Year Mortality after Hemodialysis Initiation
A high cardiothoracic ratio (CTR) is indicative of a cardiac disorder. However, few reports have revealed an association between the CTR and mortality in patients starting hemodialysis (HD). Methods: Patients with HD initiation (n = 387; mean age, 66.7 ± 12.7 years) were divided into the following three groups according to their CTR at HD initiation: CTR 55% may improve their survival.Nephron Extra 2015;5:100-110 (Source: Nephron Extra)
Source: Nephron Extra - December 19, 2015 Category: Urology & Nephrology Source Type: research
Prehospitalization Risk Factors for Acute Kidney Injury during Hospitalization for Serious Infections in the REGARDS Cohort
In this study, we determined prehospitalization characteristics associated with AKI in community-dwelling adults hospitalized for a serious infection. Methods: We used prospective data from 30,239 participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, a national cohort of community-dwelling adults ≥45 years old. We identified serious infection hospitalizations between 2003 and 2012. Using the Kidney Disease Improving Global Outcomes (KDIGO) criteria, we defined AKI as an increase in serum creatinine (sCr) ≥0.3 mg/dl from the first inpatient sCr measurement during the first 7 hospit...
Source: Nephron Extra - November 10, 2015 Category: Urology & Nephrology Source Type: research
Factors Contributing to Erythropoietin Hyporesponsiveness in Patients on Long-Term Continuous Ambulatory Peritoneal Dialysis: A Cross-Sectional Study
Conclusions: This study demonstrates that ECW/TBW was a factor contributing to ERI and that appropriate maintenance of body fluid volume could contribute to low EPO dosing.Nephron Extra 2015;5:79-86 (Source: Nephron Extra)
Source: Nephron Extra - October 29, 2015 Category: Urology & Nephrology Source Type: research
Vasoactive Peptide Levels after Change of Dialysis Mode
Conclusion: The postdialysis plasma levels of NT-proBNP, BNP and NPY decreased significantly during both dialysis modes when compared to before dialysis. The postdialysis lowering of NT-proBNP increased further over time after the switch to ol-HDF; the predialysis levels were unchanged, suggesting no effect on its production in the ventricles of the heart.Nephron Extra 2015;5:67-78 (Source: Nephron Extra)
Source: Nephron Extra - October 29, 2015 Category: Urology & Nephrology Source Type: research
Approximation of Corrected Calcium Concentrations in Advanced Chronic Kidney Disease Patients with or without Dialysis Therapy
Conclusion: Compared to other formulas, the approximated corrected TCa values calculated from the new formula for patients with CKD G4 + G5 and CKD G5D demonstrates superior agreement with the measured corrected TCa.Nephron Extra 2015;5:39-49 (Source: Nephron Extra)
Source: Nephron Extra - September 2, 2015 Category: Urology & Nephrology Source Type: research
Thrice-Weekly Nocturnal In-Centre Haemodiafiltration: A 2-Year Experience
Conclusion: Phosphate control can be achieved without the need for binders or supplementation on a thrice-weekly in-centre haemodiafiltration program.Nephron Extra 2015;5:50-57 (Source: Nephron Extra)
Source: Nephron Extra - August 29, 2015 Category: Urology & Nephrology Source Type: research
A Prospective Observational Survey on the Long-Term Effect of LDL Apheresis on Drug-Resistant Nephrotic Syndrome
Background/Aims: LDL apheresis (LDL-A) is used for drug-resistant nephrotic syndrome (NS) as an alternative therapy to induce remission by improvement of hyperlipidemia. Several clinical studies have suggested the efficacy of LDL-A for refractory NS, but the level of evidence remains insufficient. A multicenter prospective study, POLARIS (Prospective Observational Survey on the Long-Term Effects of LDL Apheresis on Drug-Resistant Nephrotic Syndrome), was conducted to evaluate its clinical efficacy with high-level evidence. Methods: Patients with NS who showed resistance to primary medication for at least 4 weeks were prosp...
Source: Nephron Extra - August 29, 2015 Category: Urology & Nephrology Source Type: research
A Case of Fibrillary Glomerulonephritis Associated with Thrombotic Microangiopathy and Anti-Glomerular Basement Membrane Antibody
In conclusion, it was shown that TMA, FGN and anti-GBM antibody were closely related.Nephron Extra 2015;5:30-38 (Source: Nephron Extra)
Source: Nephron Extra - February 26, 2015 Category: Urology & Nephrology Source Type: research
Lipid Levels and Renal Function Decline in Pre-Dialysis Patients
Background: Little is known about the effect of low-density lipoprotein (LDL) cholesterol, triglyceride (TG), and high-density lipoprotein (HDL) cholesterol levels on renal function decline in patients receiving specialized pre-dialysis care. Methods: In the prospective PREPARE-2 study, incident patients starting pre-dialysis care were included when referred to one of the 25 participating Dutch specialized pre-dialysis outpatient clinics (2004-2011). Clinical and laboratory data were collected every 6 months. A linear mixed model was used to compare renal function decline between patients with LDL cholesterol, TG, or HDL c...
Source: Nephron Extra - February 3, 2015 Category: Urology & Nephrology Source Type: research
