Effects of Tumor Necrosis Factor- α on Podocyte Expression of Monocyte Chemoattractant Protein-1 and in Diabetic Nephropathy

Conclusion: < /i > < /b > TNF- α potently stimulates podocytes to produce MCP-1, utilizing the TNFR2 receptor and the NF-#954;B and PI3K/Akt pathways. Both TNF-α and MCP-1 levels were increased in the urine of diabetic < i > db/db < /i > mice, correlating with the severity of diabetic albuminuria. < br / > Nephron Extra 2015;5:1-18
Source: Nephron Extra - Category: Urology & Nephrology Source Type: research